Inga Songailiene
@ingasongailiene.bsky.social
Reposted by Inga Songailiene
Excited to see our work published in @ScienceAdvances
!
We present RBPseg, a method for structural prediction of #phage receptor-binding proteins.
We applied it to diverse tail fibers and validated the predicted structures using #cryoEM.
Read here: www.science.org/doi/10.1126/...
!
We present RBPseg, a method for structural prediction of #phage receptor-binding proteins.
We applied it to diverse tail fibers and validated the predicted structures using #cryoEM.
Read here: www.science.org/doi/10.1126/...
RBPseg: Toward a complete phage tail fiber structure atlas
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
www.science.org
June 10, 2025 at 6:20 AM
Excited to see our work published in @ScienceAdvances
!
We present RBPseg, a method for structural prediction of #phage receptor-binding proteins.
We applied it to diverse tail fibers and validated the predicted structures using #cryoEM.
Read here: www.science.org/doi/10.1126/...
!
We present RBPseg, a method for structural prediction of #phage receptor-binding proteins.
We applied it to diverse tail fibers and validated the predicted structures using #cryoEM.
Read here: www.science.org/doi/10.1126/...
Reposted by Inga Songailiene
Thrilled to see Leyre’s PhD work finally out!
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states - Nature Communications
Marín-Arraiza and colleagues report the cryo-EM structures of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states, providing structural insigh...
www.nature.com
October 22, 2025 at 1:25 PM
Thrilled to see Leyre’s PhD work finally out!
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
Reposted by Inga Songailiene
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
June 30, 2025 at 7:45 PM
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
Super nice work! ✨️🪄
It was so great to hear it presented in Paris.
It was so great to hear it presented in Paris.
A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 1, 2025 at 5:10 PM
Super nice work! ✨️🪄
It was so great to hear it presented in Paris.
It was so great to hear it presented in Paris.
Very cool system! 👀
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses
phage attachment at the membrane and assembles a transmembrane complex that halts
infection by blocking phage DNA re...
www.cell.com
August 1, 2025 at 8:10 PM
Very cool system! 👀
Impressive spacer selection mechanism by Cas9-adaptation supercomplexes - all pathway captured by #cryoEM #Cas9 🧬🧩🧵
'Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation'
Check out our preprint on #bioRxiv on the #Cas9-Cas1-Cas2-Csn2 supercomplex involved in #CRISPR spacer acquisition: www.biorxiv.org/cgi/content/...
Thread below.
Check out our preprint on #bioRxiv on the #Cas9-Cas1-Cas2-Csn2 supercomplex involved in #CRISPR spacer acquisition: www.biorxiv.org/cgi/content/...
Thread below.
June 13, 2025 at 11:48 AM
Reposted by Inga Songailiene
And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣
April 8, 2025 at 4:59 AM
And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣
Reposted by Inga Songailiene
Very interesting paper from Feng Zhang's group describing that the origin of #CRISPR RNA targeting system Cas13 is from the HEPN RNA-Toxin antitoxin system Abi-F. It also Assert that Cas13an described from the Doudna lab earlier this year is in fact a Cas13 intermediate. www.cell.com/cell/fulltex...
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Hybrid structure-sequence mining and biochemical/structural characterization trace
the evolutionary origins of CRISPR-Cas13, elucidating how their RNA-guided mechanism
likely evolved from an ancient s...
www.cell.com
February 19, 2025 at 12:59 AM
Very interesting paper from Feng Zhang's group describing that the origin of #CRISPR RNA targeting system Cas13 is from the HEPN RNA-Toxin antitoxin system Abi-F. It also Assert that Cas13an described from the Doudna lab earlier this year is in fact a Cas13 intermediate. www.cell.com/cell/fulltex...
Reposted by Inga Songailiene
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
February 6, 2025 at 6:05 AM
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
January 13th is the Day of the Defenders of Freedom of Lithuania 🇱🇹
To commemorate it, we run 9km around the Kastellet fortress in Copenhagen 🫶
To commemorate it, we run 9km around the Kastellet fortress in Copenhagen 🫶
January 12, 2025 at 5:16 PM
January 13th is the Day of the Defenders of Freedom of Lithuania 🇱🇹
To commemorate it, we run 9km around the Kastellet fortress in Copenhagen 🫶
To commemorate it, we run 9km around the Kastellet fortress in Copenhagen 🫶