Daniel Goldhill
@influenzal.bsky.social
Scientist. Lecturer in Virology at RVC. Likes experimental evolution, influenza, coronaviruses, desserts. Main life goal: never running a western blot.
Reposted by Daniel Goldhill
My jaw dropped at the first paragraph. By Alice Klein www.newscientist.com/article/2511...
Melatonin gummies as sleep aids for children: What are the risks?
To eliminate bedtime struggles, a growing number of parents have turned to melatonin gummies, but these hormone supplements are largely unregulated. Columnist Alice Klein digs into the evidence on the...
www.newscientist.com
February 2, 2026 at 11:52 AM
My jaw dropped at the first paragraph. By Alice Klein www.newscientist.com/article/2511...
Reposted by Daniel Goldhill
🚨New Pre-Print🚨
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
January 30, 2026 at 12:01 PM
🚨New Pre-Print🚨
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Reposted by Daniel Goldhill
Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
www.grc.org
January 29, 2026 at 3:03 PM
Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
Reposted by Daniel Goldhill
Excited about parasites? Love watching movies? Come join our Wellcome-funded project! Parasitology friends, please do share far and wide.
January 28, 2026 at 5:05 PM
Excited about parasites? Love watching movies? Come join our Wellcome-funded project! Parasitology friends, please do share far and wide.
Reposted by Daniel Goldhill
Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex
Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus.
www.science.org
January 24, 2026 at 1:42 PM
Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel Goldhill
Really excited our paper about how H5N1 rapidly adapted to cattle (and how these adaptations also increased its ability to infect cells from the human respiratory tract) is now published! www.nature.com/articles/s41...
Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals - Nature Communications
Avian influenza jumped from wild birds into dairy cattle. Here, the authors report that two mutations in the viral polymerase helped the virus to quickly adapt to cattle. Mutations increased the polym...
www.nature.com
January 20, 2026 at 2:10 PM
Really excited our paper about how H5N1 rapidly adapted to cattle (and how these adaptations also increased its ability to infect cells from the human respiratory tract) is now published! www.nature.com/articles/s41...
Reposted by Daniel Goldhill
Interested in high containment work on viruses?
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
CL3- Research Assistant
The Pirbright Institute
The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic a...
isw.changeworknow.co.uk
January 20, 2026 at 2:12 PM
Interested in high containment work on viruses?
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...
Reposted by Daniel Goldhill
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
January 9, 2026 at 11:44 AM
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
Reposted by Daniel Goldhill
www.science.org/doi/10.1126/... It's finally out! Meriam Guellil expertly led this project from the first HHV6 detection to the final paper. We found both human herpesviruses 6A and 6B in ancient remains going back 2500 years.
January 2, 2026 at 7:53 PM
www.science.org/doi/10.1126/... It's finally out! Meriam Guellil expertly led this project from the first HHV6 detection to the final paper. We found both human herpesviruses 6A and 6B in ancient remains going back 2500 years.
Reposted by Daniel Goldhill
Here is what I think the research team to whom RFK Jr. just gave $1.6 million to do a randomized controlled trial of HepB vaccine in Guinea-Bissau is going to do.
Although the WHO recommendation is to administer the HepB vaccine at birth, infants in G-B usually get it at 6 weeks, not at birth.
Although the WHO recommendation is to administer the HepB vaccine at birth, infants in G-B usually get it at 6 weeks, not at birth.
December 18, 2025 at 6:08 AM
Here is what I think the research team to whom RFK Jr. just gave $1.6 million to do a randomized controlled trial of HepB vaccine in Guinea-Bissau is going to do.
Although the WHO recommendation is to administer the HepB vaccine at birth, infants in G-B usually get it at 6 weeks, not at birth.
Although the WHO recommendation is to administer the HepB vaccine at birth, infants in G-B usually get it at 6 weeks, not at birth.
I enjoyed reading this a lot!
I wrote this, a long analysis of a single line of Shakespeare and what it’s doing. How good writing is an ethical practice. And my continuing attempts to work out what it is that I’m spotting when I look at a piece of text and go “oh that was written by AI.”
open.substack.com/pub/naomiald...
open.substack.com/pub/naomiald...
a single line of Shakespeare contains an ethical universe
on what we get from individual word choice, what good writing is, plus: what I put in my ChatGPT settings to make it helpful
open.substack.com
December 14, 2025 at 9:13 AM
I enjoyed reading this a lot!
Reposted by Daniel Goldhill
So excited to share this work led by @alexrob.bsky.social with Ben Kerr!
We investigated a poliovirus capsid inhibitor that exploits a breakdown in the genotype-phenotype map to prevent drug resistance evolution. Or does it?
See Alex's thread, but a few extras:
#socialviruses #evosky #virosky 🧪
We investigated a poliovirus capsid inhibitor that exploits a breakdown in the genotype-phenotype map to prevent drug resistance evolution. Or does it?
See Alex's thread, but a few extras:
#socialviruses #evosky #virosky 🧪
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
www.nature.com
December 10, 2025 at 9:07 PM
So excited to share this work led by @alexrob.bsky.social with Ben Kerr!
We investigated a poliovirus capsid inhibitor that exploits a breakdown in the genotype-phenotype map to prevent drug resistance evolution. Or does it?
See Alex's thread, but a few extras:
#socialviruses #evosky #virosky 🧪
We investigated a poliovirus capsid inhibitor that exploits a breakdown in the genotype-phenotype map to prevent drug resistance evolution. Or does it?
See Alex's thread, but a few extras:
#socialviruses #evosky #virosky 🧪
Reposted by Daniel Goldhill
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution
A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...
www.nature.com
December 8, 2025 at 5:15 PM
My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)
Finished a virology PhD or finishing soon? Check out this job - www.healthjobsuk.com/job/UK/Londo...
Job vacancy: Healthcare Scientist, UK Health Security Agency, London | trac.jobs
www.healthjobsuk.com
November 14, 2025 at 12:16 PM
Finished a virology PhD or finishing soon? Check out this job - www.healthjobsuk.com/job/UK/Londo...
Reposted by Daniel Goldhill
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
www.nature.com
November 12, 2025 at 7:33 PM
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
Reposted by Daniel Goldhill
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
November 11, 2025 at 8:38 PM
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
Reposted by Daniel Goldhill
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 3:17 AM
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
November 4, 2025 at 11:14 AM
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
Reposted by Daniel Goldhill
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Guys- new spillover route just dropped.
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 27, 2025 at 11:17 PM
Guys- new spillover route just dropped.
Reposted by Daniel Goldhill
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Dr Jeremy Keown
Dr Jeremy Keown
warwick.ac.uk
October 24, 2025 at 7:58 AM
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Reposted by Daniel Goldhill
🧵🚨
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
UK’s arm’s length public bodies are highly vulnerable to politicisation
Seven in ten Britons say it is important for top scientific institutions to be independent in exclusive new polling.
www.ucl.ac.uk
October 9, 2025 at 3:47 PM
🧵🚨
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
The UK’s independent scientific bodies are highly vulnerable to politicisation - over the past 5 months I've been working with @martinmckee.bsky.social to map out their vulnerabilities and it's not good news.
Today our report is published!
www.ucl.ac.uk/policy-lab/n...
1/11
Reposted by Daniel Goldhill
Excited to share that our paper on the relationship between viral load and metagenomic outputs in wildlife samples is now published in Microbial Genomics @microbiologysociety! 🎉 Fantastic collaboration with a brilliant team.
More info: 📖 tinyurl.com/ywb7tvjm
More info: 📖 tinyurl.com/ywb7tvjm
Quantifying viral load and characterizing virus diversity in wildlife samples with target enrichment sequencing
Metagenomics is a powerful tool for characterizing viruses, with broad applications across diverse disciplines, from understanding the ecology and evolutionary history of viruses to identifying causat...
tinyurl.com
September 29, 2025 at 11:23 AM
Excited to share that our paper on the relationship between viral load and metagenomic outputs in wildlife samples is now published in Microbial Genomics @microbiologysociety! 🎉 Fantastic collaboration with a brilliant team.
More info: 📖 tinyurl.com/ywb7tvjm
More info: 📖 tinyurl.com/ywb7tvjm
Reposted by Daniel Goldhill
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025
The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...
www.biorxiv.org
September 8, 2025 at 9:48 PM
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...