Jia-Xing Yue (岳家兴)
@iamphioxus.bsky.social
PI of @EvomicsLab.bsky.social (www.evomicslab.org)
at Sun Yat-sen University Cancer Center (SYSUCC)
Alumni of @cnrs.fr @ircan.bsky.social @RiceUniversity @NanjingUnivers1
at Sun Yat-sen University Cancer Center (SYSUCC)
Alumni of @cnrs.fr @ircan.bsky.social @RiceUniversity @NanjingUnivers1
It is great to have @petrovadmitri.bsky.social here at Sun Yat-sen University Cancer Center to give us an highly inspiring talk on “Fitness landscape of tumor suppressor genes in lung cancer ”. Tour de force experiments, mind blowing results, and exciting bench-to-bed perspectives!
July 29, 2025 at 4:20 AM
It is great to have @petrovadmitri.bsky.social here at Sun Yat-sen University Cancer Center to give us an highly inspiring talk on “Fitness landscape of tumor suppressor genes in lung cancer ”. Tour de force experiments, mind blowing results, and exciting bench-to-bed perspectives!
Reposted by Jia-Xing Yue (岳家兴)
First #SMBE meeting for our lab！Definitely a memorable experience. Already looking forward to the next one! @official-smbe.bsky.social #SMBE2025
July 25, 2025 at 3:47 PM
First #SMBE meeting for our lab！Definitely a memorable experience. Already looking forward to the next one! @official-smbe.bsky.social #SMBE2025
Reposted by Jia-Xing Yue (岳家兴)
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
tinyurl.com
July 23, 2025 at 3:12 PM
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Super honored to have chance to co-organize the #SMBE2025 Symposium on Experimental Evolution, together with @jingli-0512.bsky.social and Dao-Qiong Zheng. Thank @petrovadmitri.bsky.social for serving as our invited speaker. Also thank all the oral/poster presenters and audience. @OfficialSMBE
July 22, 2025 at 11:50 PM
Super honored to have chance to co-organize the #SMBE2025 Symposium on Experimental Evolution, together with @jingli-0512.bsky.social and Dao-Qiong Zheng. Thank @petrovadmitri.bsky.social for serving as our invited speaker. Also thank all the oral/poster presenters and audience. @OfficialSMBE
📣Our #SMBE 2025 Symposium (No. 3) on Experimental Evolution will be held today (7.22, Tuesday) at 10:30 in Room 4, Building No. 8. An associated poster session will be held at 14:00 (poster number: S3-P01~P16). Welcome to join! let's study evolution in action! 🥳 🎉 @official-smbe.bsky.social
July 21, 2025 at 11:21 PM
📣Our #SMBE 2025 Symposium (No. 3) on Experimental Evolution will be held today (7.22, Tuesday) at 10:30 in Room 4, Building No. 8. An associated poster session will be held at 14:00 (poster number: S3-P01~P16). Welcome to join! let's study evolution in action! 🥳 🎉 @official-smbe.bsky.social
Reposted by Jia-Xing Yue (岳家兴)
📅 The day is today!
#SMBE2025 in Beijing starts now, as the registration desk opens to all participants.
Join us for five days full of the latest discoveries in molecular biology and evolution 🧬 We hope all attendees enjoy the many opportunities for discussion and networking among our community.
#SMBE2025 in Beijing starts now, as the registration desk opens to all participants.
Join us for five days full of the latest discoveries in molecular biology and evolution 🧬 We hope all attendees enjoy the many opportunities for discussion and networking among our community.
July 20, 2025 at 4:08 AM
📅 The day is today!
#SMBE2025 in Beijing starts now, as the registration desk opens to all participants.
Join us for five days full of the latest discoveries in molecular biology and evolution 🧬 We hope all attendees enjoy the many opportunities for discussion and networking among our community.
#SMBE2025 in Beijing starts now, as the registration desk opens to all participants.
Join us for five days full of the latest discoveries in molecular biology and evolution 🧬 We hope all attendees enjoy the many opportunities for discussion and networking among our community.
Reposted by Jia-Xing Yue (岳家兴)
Our latest paper is out: rdcu.be/ev6Ym — one of my favorite projects. It began about 8 years ago when Nobel laureate Torsten Wiesel asked me: what transcription factors regulate new genes? I had no idea then. Now we have some answers.
Gene regulatory networks and essential transcription factors for de novo-originated genes
Nature Ecology & Evolution - A combination of computational methods applied to single-cell RNA sequencing data and genetic experiments shows that a small number of transcription factors are...
rdcu.be
July 15, 2025 at 2:27 PM
Our latest paper is out: rdcu.be/ev6Ym — one of my favorite projects. It began about 8 years ago when Nobel laureate Torsten Wiesel asked me: what transcription factors regulate new genes? I had no idea then. Now we have some answers.
Welcome to attend our SMBE2025 Symposium on Experimental Evolution. Co-organized by Dao-Qiong Zheng, @jingli-0512.bsky.social and myself.
#SMBE2025 Symposium 3: Experimental evolution: studying evolution in action
🔗 smbe2025.scimeeting.cn/en/web/program/25070
🔗 smbe2025.scimeeting.cn/en/web/program/25070
June 17, 2025 at 1:45 AM
Welcome to attend our SMBE2025 Symposium on Experimental Evolution. Co-organized by Dao-Qiong Zheng, @jingli-0512.bsky.social and myself.
Reposted by Jia-Xing Yue (岳家兴)
Very excited about this work by @mrazo.bsky.social in collaboration with www.madhavmani.com bsky.app/profile/mraz... I am so lucky to be able to collaborate with such brilliant people! Learned a lot. This is our first foray into ML approaches and I am quite taken with their power 1/n
May 15, 2025 at 6:16 PM
Very excited about this work by @mrazo.bsky.social in collaboration with www.madhavmani.com bsky.app/profile/mraz... I am so lucky to be able to collaborate with such brilliant people! Learned a lot. This is our first foray into ML approaches and I am quite taken with their power 1/n
Reposted by Jia-Xing Yue (岳家兴)
Keynote talk from Steven McCarroll from last weeks Biology of Genomes conf. My favorite talk of the whole meeting! #bog25 youtu.be/BCRAlmFv7ag?...
CSHL Keynote, Dr. Steven McCarroll, Harvard Medical School + Broad Institute
YouTube video by CSHL Leading Strand
youtu.be
May 15, 2025 at 12:39 AM
Keynote talk from Steven McCarroll from last weeks Biology of Genomes conf. My favorite talk of the whole meeting! #bog25 youtu.be/BCRAlmFv7ag?...
Reposted by Jia-Xing Yue (岳家兴)
📢 3 Postdoc positions available in @evomicslab.bsky.social
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
Evomics Lab – Exploring Omics in the Light of Evolution
evomicslab.org
April 28, 2025 at 6:17 AM
📢 3 Postdoc positions available in @evomicslab.bsky.social
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
Reposted by Jia-Xing Yue (岳家兴)
Uncalled4: a toolkit for nanopore signal alignment, analysis and visualization of DNA and RNA modifications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 28, 2025 at 5:23 PM
Uncalled4: a toolkit for nanopore signal alignment, analysis and visualization of DNA and RNA modifications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jia-Xing Yue (岳家兴)
1/35 New paper out! @jamesTstroud and I dive into why long-term studies are crucial for understanding evolution. They reveal processes impossible to detect in short timescales and capture rare events that transform our understanding of evolutionary dynamics.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 19, 2025 at 7:18 PM
1/35 New paper out! @jamesTstroud and I dive into why long-term studies are crucial for understanding evolution. They reveal processes impossible to detect in short timescales and capture rare events that transform our understanding of evolutionary dynamics.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jia-Xing Yue (岳家兴)
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Research opportunities | Landry Lab
landrylab.ibis.ulaval.ca
February 23, 2025 at 4:46 PM
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Reposted by Jia-Xing Yue (岳家兴)
Glad to see the copy-edited version of our VRPG paper formally published in the latest issue of @genomeresearch.bsky.social ! We developed VRPG as a novel visualization framework for intuitively exploring pangenome graphs in a linear-reference-projected context.
genome.cshlp.org/content/35/2...
genome.cshlp.org/content/35/2...
Interactive visualization and interpretation of pangenome graphs by linear reference–based coordinate projection and annotation integration
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
February 15, 2025 at 7:08 AM
Glad to see the copy-edited version of our VRPG paper formally published in the latest issue of @genomeresearch.bsky.social ! We developed VRPG as a novel visualization framework for intuitively exploring pangenome graphs in a linear-reference-projected context.
genome.cshlp.org/content/35/2...
genome.cshlp.org/content/35/2...
Reposted by Jia-Xing Yue (岳家兴)
The new issue of @genomeresearch.bsky.social is now live! Follow the link to new research on homeodomain–DNA cooperative dimerization in developmental defects, nucleic quasi-primes, and more! tinyurl.com/Genome-Res-3...
February 14, 2025 at 9:41 PM
The new issue of @genomeresearch.bsky.social is now live! Follow the link to new research on homeodomain–DNA cooperative dimerization in developmental defects, nucleic quasi-primes, and more! tinyurl.com/Genome-Res-3...
📢📢📢 The FINAL COUNT DOWN for the extended abstract submission deadline of #SMBE2025! Please submit your abstract by 23:59 (GMT +8) of February 15, 2025 [Saturday]! And shout out again for our symposium on Experimental Evolution ! 🎉🎉🎉 @OfficialSMBE
#LTEE #ExperimentalEvolution
#LTEE #ExperimentalEvolution
📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025
We also invite you to register at www.smbe2025.org
@SMBEmeetings
We also invite you to register at www.smbe2025.org
@SMBEmeetings
February 12, 2025 at 12:58 PM
📢📢📢 The FINAL COUNT DOWN for the extended abstract submission deadline of #SMBE2025! Please submit your abstract by 23:59 (GMT +8) of February 15, 2025 [Saturday]! And shout out again for our symposium on Experimental Evolution ! 🎉🎉🎉 @OfficialSMBE
#LTEE #ExperimentalEvolution
#LTEE #ExperimentalEvolution
Reposted by Jia-Xing Yue (岳家兴)
A very significant step forward for synthetic genomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineering a genomically recoded organism with one stop codon - Nature
Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...
www.nature.com
February 6, 2025 at 11:35 AM
A very significant step forward for synthetic genomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jia-Xing Yue (岳家兴)
📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025
We also invite you to register at www.smbe2025.org
@SMBEmeetings
We also invite you to register at www.smbe2025.org
@SMBEmeetings
January 27, 2025 at 9:35 AM
📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025
We also invite you to register at www.smbe2025.org
@SMBEmeetings
We also invite you to register at www.smbe2025.org
@SMBEmeetings
Reposted by Jia-Xing Yue (岳家兴)
📢 #Yeast2025 News!
Registration and abstract submission are NOW OPEN!
Join us at the 32nd ICYGMB
📅 Save the Date: 21-24 July 2025
📍 Location: Paris @sorbonne-universite.fr
🔗 Submit: premc.org/yeast2025/su...
🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...
Registration and abstract submission are NOW OPEN!
Join us at the 32nd ICYGMB
📅 Save the Date: 21-24 July 2025
📍 Location: Paris @sorbonne-universite.fr
🔗 Submit: premc.org/yeast2025/su...
🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...
January 14, 2025 at 7:28 AM
📢 #Yeast2025 News!
Registration and abstract submission are NOW OPEN!
Join us at the 32nd ICYGMB
📅 Save the Date: 21-24 July 2025
📍 Location: Paris @sorbonne-universite.fr
🔗 Submit: premc.org/yeast2025/su...
🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...
Registration and abstract submission are NOW OPEN!
Join us at the 32nd ICYGMB
📅 Save the Date: 21-24 July 2025
📍 Location: Paris @sorbonne-universite.fr
🔗 Submit: premc.org/yeast2025/su...
🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...
Reposted by Jia-Xing Yue (岳家兴)
The new issue of @genomeresearch.bsky.social is now live! Follow the link to new research on AI in cell-free DNA diagnostics, disease progression insights using single-cell/-nucleus genomics, and more! tinyurl.com/Genome-Res-3...
January 22, 2025 at 4:30 PM
The new issue of @genomeresearch.bsky.social is now live! Follow the link to new research on AI in cell-free DNA diagnostics, disease progression insights using single-cell/-nucleus genomics, and more! tinyurl.com/Genome-Res-3...
The last 10-day countdown for abstract submission! Welcome to spread the word and of course welcome to submit the abstract!!! 📢😃⏰
📢 2nd-round abstract submission call for the 2025 @OfficialSMBE
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!
January 21, 2025 at 7:01 AM
The last 10-day countdown for abstract submission! Welcome to spread the word and of course welcome to submit the abstract!!! 📢😃⏰
Reposted by Jia-Xing Yue (岳家兴)
Cool paper on evolutionary constraints and trajectories shaping point centromere evolution in budding yeasts by @helsenjana.bsky.social @gautamdey.bsky.social @gsherloc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Centromeres evolve progressively through selection at the kinetochore interface
During mitosis, stable but dynamic interactions between the centromere DNA and kinetochore complex enable accurate and efficient chromosome segregation. Even though many proteins of the kinetochore ar...
www.biorxiv.org
January 17, 2025 at 1:25 PM
Cool paper on evolutionary constraints and trajectories shaping point centromere evolution in budding yeasts by @helsenjana.bsky.social @gautamdey.bsky.social @gsherloc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Introducing VRPG, our recent work on the pangenome graph visualization & interpretation @genomeresearch.bsky.social !We posted our initial idea years ago and continuously improved it with many added features. Appreciate the great suggestions from all 3 reviewers. It is so much better now!
January 14, 2025 at 6:02 AM
Introducing VRPG, our recent work on the pangenome graph visualization & interpretation @genomeresearch.bsky.social !We posted our initial idea years ago and continuously improved it with many added features. Appreciate the great suggestions from all 3 reviewers. It is so much better now!
📢 2nd-round abstract submission call for the 2025 @OfficialSMBE
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!
January 10, 2025 at 2:47 PM
📢 2nd-round abstract submission call for the 2025 @OfficialSMBE
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!
annual meeting in #Beijing .
Where: smbe2025.scimeeting.cn/en/web/index...
When: now - 2025/01/30. Welcome for all abstract submissions, especially for our Experimental Evolution Symposium !!!