Helen Grimsley
@helengrimsley.bsky.social
Postdoc, Powell lab
Memorial Sloan Kettering
🧬 DNA repair, replication, drug resistance 🧬
Memorial Sloan Kettering
🧬 DNA repair, replication, drug resistance 🧬
🧬 Very excited to share another first author preprint from my PhD. 🧬
Here we show that reduced 4EBP1 leads to acquired Capivarsertib resistance via increased cap-dependent protein synthesis.
Here we show that reduced 4EBP1 leads to acquired Capivarsertib resistance via increased cap-dependent protein synthesis.
Reduced 4E-BP1 activity leads to acquired capivasertib resistance via increased cap-dependent protein synthesis. https://www.biorxiv.org/content/10.1101/2025.10.10.681642v1
October 14, 2025 at 11:23 AM
🧬 Very excited to share another first author preprint from my PhD. 🧬
Here we show that reduced 4EBP1 leads to acquired Capivarsertib resistance via increased cap-dependent protein synthesis.
Here we show that reduced 4EBP1 leads to acquired Capivarsertib resistance via increased cap-dependent protein synthesis.
Very excited to have submitted my first author from my postdoc.
We demonstrate that the 9-1-1 complex safeguards BRCA2-deficient cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation, restraining EXO1 degradation and promoting POLζ-mediated filling.
We demonstrate that the 9-1-1 complex safeguards BRCA2-deficient cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation, restraining EXO1 degradation and promoting POLζ-mediated filling.
The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer https://www.biorxiv.org/content/10.1101/2025.10.07.680950v1
October 8, 2025 at 12:55 PM
Very excited to have submitted my first author from my postdoc.
We demonstrate that the 9-1-1 complex safeguards BRCA2-deficient cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation, restraining EXO1 degradation and promoting POLζ-mediated filling.
We demonstrate that the 9-1-1 complex safeguards BRCA2-deficient cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation, restraining EXO1 degradation and promoting POLζ-mediated filling.
On my way to be there in person. But here's the stream for those that can't make it.
Want to stream our DC event & hear from amazing speakers like Bill Nye, Francis Collins, Atul Gawande, and SO MANY MORE?
Join our livestream at www.twitch.tv/standupforsc..., starting at 12 pm!
#standupforscience2025
Join our livestream at www.twitch.tv/standupforsc..., starting at 12 pm!
#standupforscience2025
March 7, 2025 at 3:57 PM
On my way to be there in person. But here's the stream for those that can't make it.
This is incredibly disturbing. Such a ridiculous, hurtful, unneeded move by a British company.
www.theguardian.com/business/202...
www.theguardian.com/business/202...
British pharma company GSK pauses diversity work citing Trump orders
London-based FTSE 100 firm reviewing its policies, saying it is obliged to comply because US is its No 1 market
www.theguardian.com
March 6, 2025 at 3:53 PM
This is incredibly disturbing. Such a ridiculous, hurtful, unneeded move by a British company.
www.theguardian.com/business/202...
www.theguardian.com/business/202...
Reposted by Helen Grimsley
Reposted by Helen Grimsley
In an unprecedented move, the US National Institutes of Health has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”.
https://go.nature.com/4bpG2It
https://go.nature.com/4bpG2It
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
go.nature.com
March 6, 2025 at 2:25 AM
In an unprecedented move, the US National Institutes of Health has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”.
https://go.nature.com/4bpG2It
https://go.nature.com/4bpG2It
Reposted by Helen Grimsley
This is a blatant violation of the 1st Amendment but a lot of cowards in academia will use this as an excuse to crack down on campus protest.
March 4, 2025 at 1:02 PM
This is a blatant violation of the 1st Amendment but a lot of cowards in academia will use this as an excuse to crack down on campus protest.
Reposted by Helen Grimsley
Today the Royal Society will meet to discuss “Fellows’ behaviour”. Without doubt the fellow they will primarily be discussing is Elon Musk.
The behaviour may range from his public dissemination of unfounded conspiracy theories to his attacks on the science
🧵
1/38
The behaviour may range from his public dissemination of unfounded conspiracy theories to his attacks on the science
🧵
1/38
March 3, 2025 at 8:21 AM
Today the Royal Society will meet to discuss “Fellows’ behaviour”. Without doubt the fellow they will primarily be discussing is Elon Musk.
The behaviour may range from his public dissemination of unfounded conspiracy theories to his attacks on the science
🧵
1/38
The behaviour may range from his public dissemination of unfounded conspiracy theories to his attacks on the science
🧵
1/38
Reposted by Helen Grimsley
If all their previous actions don't destroy scientific research in the U.S., this one, which seeks to modify or terminate grants and contracts, including those to educational institutions, will certainly do so.
It's so sad that those who have benefited from the system now seek to destroy it.
It's so sad that those who have benefited from the system now seek to destroy it.
Implementing the President's "Department of Government Efficiency" Cost Efficiency Initiative
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1.
www.whitehouse.gov
February 27, 2025 at 8:15 PM
If all their previous actions don't destroy scientific research in the U.S., this one, which seeks to modify or terminate grants and contracts, including those to educational institutions, will certainly do so.
It's so sad that those who have benefited from the system now seek to destroy it.
It's so sad that those who have benefited from the system now seek to destroy it.
Reposted by Helen Grimsley
✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)
February 27, 2025 at 8:19 PM
✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)
Reposted by Helen Grimsley
Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
www.nature.com
February 25, 2025 at 2:21 PM
Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Helen Grimsley
NEW: DOGE workers now have access to the NIH department known as the "wallet" of the entire organization. From @mattreynolds.bsky.social
www.wired.com/story/doge-i...
www.wired.com/story/doge-i...
DOGE Is Inside the National Institutes of Health’s Finance System
At least three people linked to Elon Musk’s DOGE task force have access to NIH systems that control budgets, procurement, and more, according to records and internal documents viewed by WIRED.
www.wired.com
February 24, 2025 at 7:15 PM
NEW: DOGE workers now have access to the NIH department known as the "wallet" of the entire organization. From @mattreynolds.bsky.social
www.wired.com/story/doge-i...
www.wired.com/story/doge-i...
Reposted by Helen Grimsley
Reposted by Helen Grimsley
Almost all grant-review meetings remain suspended at the US National Institutes of Health, preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/418B5Pm
https://go.nature.com/418B5Pm
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
Nature - The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
go.nature.com
February 23, 2025 at 3:39 PM
Almost all grant-review meetings remain suspended at the US National Institutes of Health, preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.
https://go.nature.com/418B5Pm
https://go.nature.com/418B5Pm
Reposted by Helen Grimsley
See you in DC!
Get in dorks, we're going protesting!
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL
Because science is for everyone!
Find us at www.standupforscience2025.org
#standupforscience2025 #scienceforall #sciencenotsilence
February 23, 2025 at 2:12 PM
See you in DC!
Reposted by Helen Grimsley
Already bruised by the Trump administration’s first round of firings of federal workers, employees at NIH faced more bad news. NIH’s 27 institute directors were told this week that the agency must cut staffing back to 2019 levels, or at least 10% below its 2024 tally. scim.ag/3EP8gjy
More NIH job cuts coming? Agency's scientists already reeling after week of firings
NIH is appealing loss of some lab leaders among in-house research program while bracing for the next actions from the Trump administration
scim.ag
February 21, 2025 at 11:52 PM
Already bruised by the Trump administration’s first round of firings of federal workers, employees at NIH faced more bad news. NIH’s 27 institute directors were told this week that the agency must cut staffing back to 2019 levels, or at least 10% below its 2024 tally. scim.ag/3EP8gjy
Great time to be looking to become an independent researcher.....
“For the last 75 yrs, the NIH has been the biggest funder of biomedical research in the world. Most advances in medicine were seeded by NIH funding. When we became scientists, we just bought into this system. This is how it works. — @tuthill.bsky.social 🧵
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Trump cuts threaten a ‘generation of scientists’ as many weigh leaving US
President’s call to ‘Make America Healthy Again’ has led to slashes in NIH funding – endangering jobs and vital research
www.theguardian.com
February 19, 2025 at 8:12 PM
Great time to be looking to become an independent researcher.....
Reposted by Helen Grimsley
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
scim.ag
February 19, 2025 at 4:54 PM
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
Reposted by Helen Grimsley
TOMORROW (WED): Rallies are being held across the country to protest the funding cuts to science and the illegal firing of federal workers.
Please join if you can. We need to show that many people oppose these destructive attacks on science and healthcare.
Details: labor4highered.org
Please join if you can. We need to show that many people oppose these destructive attacks on science and healthcare.
Details: labor4highered.org
February 18, 2025 at 10:13 PM
TOMORROW (WED): Rallies are being held across the country to protest the funding cuts to science and the illegal firing of federal workers.
Please join if you can. We need to show that many people oppose these destructive attacks on science and healthcare.
Details: labor4highered.org
Please join if you can. We need to show that many people oppose these destructive attacks on science and healthcare.
Details: labor4highered.org
Reposted by Helen Grimsley
ACTION THIS WEDNESDAY: Researchers from New York universities are holding a rally to protest the funding cuts at Washington Square Park at 4 pm.
This will be part of a national day of action, with rallies at HHS in DC and all around the country.
RSVP HERE: docs.google.com/forms/d/e/1F...
This will be part of a national day of action, with rallies at HHS in DC and all around the country.
RSVP HERE: docs.google.com/forms/d/e/1F...
February 18, 2025 at 2:17 AM
ACTION THIS WEDNESDAY: Researchers from New York universities are holding a rally to protest the funding cuts at Washington Square Park at 4 pm.
This will be part of a national day of action, with rallies at HHS in DC and all around the country.
RSVP HERE: docs.google.com/forms/d/e/1F...
This will be part of a national day of action, with rallies at HHS in DC and all around the country.
RSVP HERE: docs.google.com/forms/d/e/1F...
Reposted by Helen Grimsley
🚨 The CDC website is purging resources on LGBTQ+ health, diversity, equity, and health disparities. This is not just a bureaucratic change. It’s a dangerous decision with profound negative public health consequences. Let’s break down the harm this will cause. 🧵⬇️
January 31, 2025 at 5:24 PM
🚨 The CDC website is purging resources on LGBTQ+ health, diversity, equity, and health disparities. This is not just a bureaucratic change. It’s a dangerous decision with profound negative public health consequences. Let’s break down the harm this will cause. 🧵⬇️
Reposted by Helen Grimsley
“This is clearly a high anxiety moment”
Former NIH director Monica Bertagnolli details her concerns about Robert F. Kennedy Jr and his ‘Make America Healthy Again’ campaign
https://go.nature.com/40ALHGC
Former NIH director Monica Bertagnolli details her concerns about Robert F. Kennedy Jr and his ‘Make America Healthy Again’ campaign
https://go.nature.com/40ALHGC
‘High anxiety moment’: Biden’s NIH chief talks Trump 2.0 and the future of US science
Monica Bertagnolli details her concerns about Robert F. Kennedy Jr and his ‘Make America Healthy Again’ campaign.
go.nature.com
January 30, 2025 at 4:30 PM
“This is clearly a high anxiety moment”
Former NIH director Monica Bertagnolli details her concerns about Robert F. Kennedy Jr and his ‘Make America Healthy Again’ campaign
https://go.nature.com/40ALHGC
Former NIH director Monica Bertagnolli details her concerns about Robert F. Kennedy Jr and his ‘Make America Healthy Again’ campaign
https://go.nature.com/40ALHGC
Reposted by Helen Grimsley
Beginning to doubt that wokeness is the biggest threat to higher education
January 28, 2025 at 3:09 AM
Beginning to doubt that wokeness is the biggest threat to higher education