Abstract. Non-dual awareness (NDA) refers to a shift in consciousness in which the usual distinction between subject and object dissolves, and experience i

Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...

The mechanistic underpinnings of sustained attention, vigilance, and the ability to continue responding to critical stimuli over time, despite decades of research, are not well understood. Although su...

A classic feature of human memory is that we remember information better when it refers to ourselves. Here, the authors show that before the emergence of self-concept, infants instead remember informa...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Visual information in our everyday environment is anchored to an allocentric reference frame – a tall building remains upright even when you tilt your head, which changes the projection of the building on your retina from a vertical to a diagonal orientation. Does retinotopic cortex represent visual information in an allocentric or retinocentric reference frame? Here, we investigate which reference frame the brain uses by dissociating allocentric and retinocentric reference frames via a head tilt manipulation combined with electroencephalography (EEG). Nineteen participants completed between 1728–2880 trials during which they briefly viewed (150 ms) and then remembered (1500 ms) a randomly oriented target grating. In interleaved blocks of trials, the participant’s head was either kept upright, or tilted by 45º using a custom rotating chinrest. The target orientation could be decoded throughout the trial (using both voltage and alpha-band signals) when training and testing within head-upright blocks, and within head-tilted blocks. Importantly, we directly addressed the question of reference frames via cross-generalized decoding: If target orientations are represented in a retinocentric reference frame, a decoder trained on head-upright trials would predict a 45º offset in decoded orientation when tested on head-tilted trials (after all, a vertical building becomes diagonal on the retina after head tilt). Conversely, if target representations are allocentric and anchored to the real world, no such offset should be observed. Our analyses reveal that from the earliest stages of perceptual processing all the way throughout the delay, orientations are represented in between an allocentric and retinocentric reference frame. These results align with previous findings from physiology studies in non-human primates, and are the first to demonstrate that the human brain does not rely on a purely allocentric or retinocentric reference frame when representing visual information. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, https://ror.org/001d55x84, NEI R01-EY025872, NIMH R01-MH087214

ALT: a husky puppy is laying on the floor with its tongue out and wearing a blue collar .

The lesion network mapping method, used to identify disease-specific brain networks for clinical stimulation, produces a nearly identical network map for any given condition, according to a new study.

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How should we assess which artificial systems could be conscious? Given uncertainty about the nature and distribution of consciousness, it is promising to look for indicators of consciousness that pro...

Brain–computer interface (BCI) research has achieved remarkable technical progress but remains limited in scope, typically relying on motor and visual cortex signals in limited patient populations. We propose a paradigm shift in BCI design rooted in ideomotor theory, which conceptualizes voluntary action as driven by internally represented sensory outcomes. This underused framework offers a principled basis for next-generation BCIs that align closely with the brain’s natural intentional and action-planning architecture. We suggest a more intuitive, generalizable, and scalable path by reorienting BCIs around the ‘what for’ of action—user goals and anticipated effects. This shift is timely and feasible, enabled by advances in neural recording and artificial intelligence–based decoding of sensory representations. It may help resolve challenges of usability and generalizability in BCI design.

Brain–computer interface (BCI) research has achieved remarkable technical progress but remains limited in scope, typically relying on motor and visual cortex signals in limited patient populations. We...

In today's pattern recognition class my professor talked about PCA, eigenvectors and eigenvalues. I understood the mathematics of it. If I'm asked to find eigenvalues etc. I'll do it correctly li...

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts t...

Nicole RustDirector of Visual Memory LabDepartment of PsychologyUniversity of Pennsylvania A New-New Intellectual Framework for PsychiatryIn 1998, Eric Kandel published the brilliant essay&n...