Harsharan Bhatia
harsharanbhatia.bsky.social
Harsharan Bhatia
@harsharanbhatia.bsky.social
Spatial-Omics Team Leader @Helmholtz Munich & LMU. Alum @UCLA @Freiburg
Reposted by Harsharan Bhatia
As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳

Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....

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Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex
We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...
doi.org
January 20, 2025 at 3:40 PM
Reposted by Harsharan Bhatia
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - @erturklab.bsky.social @hendrikdietz.bsky.social go.nature.com/4gNLjeC
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
go.nature.com
January 14, 2025 at 5:21 PM
Reposted by Harsharan Bhatia
Congrats to the whole community in the
@erturklab.bsky.social including first author
@jie-luo-lab.bsky.social starting his new Lab at Purdue just last week! Nice work y'all! Amazing contribution to this growing body of work using LightSheet microscopy for whole mouse imaging. 🧪🧵🔬
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
January 14, 2025 at 3:42 PM
Our SCP-Nano paper is online now in Nature Biotechnology 🎉👏 Kudos to all the authors, collaborators and reviewers for bringing this important piece of work!
#LNP #mRNA #nanotechnology #AAV #AI #imaging #nanocarrier
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
January 14, 2025 at 3:44 PM
Amazing experience to share the stage with spatial biology experts @European Society of Spatial Biology (ESSB) and present our work of 3D spatial-Omics to an audience of 550 plus from 26 countries 🤩 Kudos to the founding members of @SpatialBio for putting together such a fantastic event 🎉👏 #3D #Omic
December 14, 2024 at 1:14 PM
Let’s celebrate together the dawn of spatial proteomics- not just in 2D but in a groundbreaking 3D fashion, thanks to our pioneering work of DISCO-MS 🎉
Spatial proteomics is crowned Method of the Year! 🎉 Explore our groundbreaking work on bringing proteomics into 3D (yes, spatial! 😉): www.cell.com/cell/pdf/S00.... And don’t miss my latest review on 3D spatial omics using tissue-clearing and AI: www.nature.com/articles/s41.... 🚀
December 10, 2024 at 10:11 AM
Check out our latest preprint-MouseMapper- charting the intact organism at cellular resolution
#obesity #AI #inflammation #neurodegeneration #proteomics
Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf
December 5, 2024 at 4:09 PM
Reposted by Harsharan Bhatia
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
November 29, 2024 at 4:01 PM