Han de Jong
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handejong.bsky.social
Han de Jong
@handejong.bsky.social
250 followers 430 following 5 posts
Neuroscientist at UC Berkeley. Interested in dopamine and motivated behavior.
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Reposted by Han de Jong
markplitt.bsky.social
I am incredibly excited and proud to share my first preprint from my postdoc! Thank you to all of the co-authors for all your hard work!
Check out the paper for big insights into plasticity mechanisms in navigation circuits! And surprising motifs for inhibitory synaptic plasticity!
yvetteefisher.bsky.social Yvette Fisher @yvetteefisher.bsky.social · Dec 15
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
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Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
December 15, 2025 at 6:43 PM
Reposted by Han de Jong
malcolmgcampbell.bsky.social
🚨Our preprint is online!🚨

www.biorxiv.org/content/10.1...

How do #dopamine neurons perform the key calculations in reinforcement #learning?

Read on to find out more! 🧵
September 19, 2025 at 1:05 PM
Reposted by Han de Jong
marisosa.bsky.social
It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵

www.nature.com/articles/s41...
A flexible hippocampal population code for experience relative to reward - Nature Neuroscience
Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...
www.nature.com
June 12, 2025 at 5:24 PM
Reposted by Han de Jong
claeneuro.bsky.social
Nature Neuroscience

What dopamine teaches depends on what the brain believes

www.nature.com/articles/s41...
What dopamine teaches depends on what the brain believes - Nature Neuroscience
How does the brain learn to predict rewards? In this issue of Nature Neuroscience, Qian, Burrell et al. show that understanding how dopamine guides learning requires knowledge of how animals interpret...
www.nature.com
June 11, 2025 at 1:47 PM
Reposted by Han de Jong
dopaminesociety.bsky.social
🧠✨ Symposia submissions are NOW OPEN for Dopamine Meeting 2026! @DopamineSociety
📍Sevilla, Spain
📅 Open: May 1, 2025
⏳ Deadline: June 16, 2025
Spread the word — don’t miss out!
#Dopamine2026
dopaminesociety.org
May 2, 2025 at 12:23 PM
handejong.bsky.social
I’m excited to present a new research project at #cosyne2025 this year!
March 27, 2025 at 6:38 PM
Reposted by Han de Jong
naoshigeuchida.bsky.social
Our new study: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts. Congrats Iku-Tsutsui Kimura, Melissa Tian and others! Led by Mitsuko Watabe-Uchida. www.nature.com/articles/s41...
March 10, 2025 at 4:32 PM
Reposted by Han de Jong
neuronroot.bsky.social
New Pre-Print led by @emilyprevost.bsky.social Glutamate-dopamine, nonglu-dopamine, and glu-only neurons and neurotransmitters they use have dissociable contributions to motivated behavior. Important to segregate DA subcell-types to better understand the many motivation-related functions of DA
February 27, 2025 at 7:52 PM
Reposted by Han de Jong
caitlinmallory.bsky.social
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!
The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
www.science.org
January 31, 2025 at 9:14 PM
Reposted by Han de Jong
petramoce.bsky.social
Help #neurosky #neuroskyence

Are you (or do you know) someone studying the transcription factor Ascl4/Mash4? 🧠 #neurodevelopment #differentiation #neurons #wiring

N.b. This is not the same as the acyl CoA synthetase protein ASCL4

I have some questions 💡

Please share! 🙏
December 2, 2024 at 6:53 AM
Reposted by Han de Jong
dcardozopinto.bsky.social
My paper is out!! 🎉

"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature

Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain

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1/n
November 25, 2024 at 4:31 PM