Global Pneumococcal Sequencing Project
LightNews LightNews
globalpneumoseq.bsky.social
Global Pneumococcal Sequencing Project
@globalpneumoseq.bsky.social
12 followers 1 following 31 posts
GPS, the Global Pneumococcal Sequencing project funded by The Bill and Melinda Gates Foundation is sequencing ~50,000 pneumococci to monitor global vaccine implementation and impact.
https://www.pneumogen.net/gps/
Posts Replies Media Videos
globalpneumoseq.bsky.social
🦠🧪🧬 Excited to share that our GPS Pipeline, the portable and scalable genomic pipeline for Streptococcus pneumoniae surveillance, is now published in @natcomms.nature.com
🔗 nature.com/articles/s41... #GPS_project
GPS Pipeline: portable, scalable genomic pipeline for Streptococcus pneumoniae surveillance from Global Pneumococcal Sequencing Project - Nature Communications
The GPS Pipeline enables accessible and scalable genomic surveillance of Streptococcus pneumoniae. It performs quality control and in silico typing of sequencing reads with high accuracy using a single simple command, without requiring the internet.
nature.com
September 24, 2025 at 1:02 PM
globalpneumoseq.bsky.social
[New pre-print🚨] When a single genotype (pbp) confer resistance (penicillin, amoxicillin, cephalosporins) to multiple antibiotics, how do we make sense of genetic changes and their impact on AMR?

A new concept - AMR cartography is invented.

www.biorxiv.org/content/10.1...
www.biorxiv.org
September 22, 2025 at 11:48 AM
globalpneumoseq.bsky.social
[🚨 New paper] The first nationwide, longitudinal WGS analysis of Streptococcus pneumoniae in Taiwan (2006–2022).

1,343 isolates from 27 hospitals, we track serotype, AMR, and genomic lineage before and after PCV13.

#GPS_project #PCV13_impact #Taiwan

www.microbiologyresearch.org/content/jour...
Genomic analysis of the Streptococcus pneumoniae in Taiwan: a nationwide study from 2006 to 2022
Streptococcus pneumoniae remains a leading respiratory pathogen for children and the elderly. In Taiwan, a national PCV13 catch-up vaccination programme for children began in March 2013. This study in...
www.microbiologyresearch.org
September 18, 2025 at 8:11 AM
Reposted by Global Pneumococcal Sequencing Project
stephlo.bsky.social
[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬

www.cell.com/cell-host-mi...
Naturally acquired promoter variation influences Streptococcus pneumoniae infection outcomes
Barton et al. identify Streptococcus pneumoniae promoters containing repetitive nucleotide sequences that promote DNA strand slippage and accumulation of promoter sequence mutations. This drives popul...
www.cell.com
September 3, 2025 at 10:00 AM
globalpneumoseq.bsky.social
Each year, over half a million of pneumococcal disease in children were reported in China

Our paper showed
1) 94.3% serotypes covered by PCV13
2) 99.8% isolates resistant to ≥1 antibiotics

Routine PCV in children will ↘️ pneumococcal disease and AMR!

www.microbiologyresearch.org/content/jour...
Genomic analysis of invasive and non-invasive disease-causing Streptococcus pneumoniae isolated from children between 2014 and 2023 in Suzhou, China
In 2017, 553,000 clinical cases of Streptococcus pneumoniae in children were reported in China, although the pneumococcal conjugate vaccine (PCV), which targets the pneumococcal capsule, is not includ...
www.microbiologyresearch.org
June 3, 2025 at 12:25 PM
globalpneumoseq.bsky.social
Last week in #Europneumo2025, the GPS core team presents

1) Database of 26k pneumococcal genomes @harryhung.bsky.social
2) Global population structure of serotype 12F @dralannah.bsky.social
3) SeroBA - WGS-based tool to detect 102 known pneumococcal serotypes @OliverLorenz
June 2, 2025 at 10:46 PM
globalpneumoseq.bsky.social
Keeping track on the number of hashtag#pneumococcal serotypes?

SeroBAnk is an atlas of pneumococcal capsule to display its genetics, biochemical structure and serological profiles

www.pneumogen.net/gps/#/serobank
GPS :: Global Pneumococcal Sequencing Project
Homepage of The Global Pneumococcal Sequencing Project
www.pneumogen.net
May 1, 2025 at 3:56 PM
globalpneumoseq.bsky.social
Do you need a #bioinformatic tool to detect almost all serotypes in #pneumococci?

The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes

www.biorxiv.org/content/10.1...
SeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniae
The unprecedented number of Streptococcus pneumoniae (the pneumococcus) genomes sequenced in recent years has accelerated the discovery of novel serotypes and highlighted the genetic diversity both be...
www.biorxiv.org
May 1, 2025 at 3:43 PM
globalpneumoseq.bsky.social
What does a two-decade surveillance on pneumococcal bacteraemia in Gelderland Netherlands tell us?
www.microbiologyresearch.org/content/jour...
Investigating two decades of Streptococcus pneumoniae bacteraemia in the Gelderland area, the Netherlands, using whole-genome sequencing
In the Netherlands, the 7-valent pneumococcal conjugate vaccine (PCV) was introduced to the childhood immunization programme in 2006 and replaced by the 10-valent PCV (PCV10, GSK) in 2011. To describe...
www.microbiologyresearch.org
March 24, 2025 at 11:56 AM
globalpneumoseq.bsky.social
As part of the #GPS_project, @Abel_AberaN
led us to understand the circulating #pneumococcal lineages (carriage and disease)!in Ethiopia after #PCV10
www.microbiologyresearch.org/content/jour...
Genomic characterization of Streptococcus pneumoniae isolates obtained from carriage and disease among paediatric patients in Addis Ababa, Ethiopia
Background and aims. Despite the introduction of pneumococcal conjugate vaccines (PCVs), Streptococcus pneumoniae still remains an important cause of morbidity and mortality, especially among children...
www.microbiologyresearch.org
March 24, 2025 at 11:45 AM