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giovannilandoni.bsky.social
@giovannilandoni.bsky.social
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giovannilandoni.bsky.social
this is a materpiece by the young and brilliant @filippodamico.bsky.social

everything you know about blood pressure targets is from (old) animal studies

and different animals have different thresholds!

freely availbale on @signavitaejournal.bsky.social
signavitaejournal.bsky.social Signa Vitae @signavitaejournal.bsky.social · Aug 8
🫘Is 80 mmHg really the magic number for kidney protection?

Our review shows it’s not that simple, the real lower limit of renal autoregulation may be far lower, and disease-specific

❓Time to rethink blood pressure targets

🔗 doi.org/10.22514/sv.2025.001

#CriticalCare #Anesthesia
August 8, 2025 at 2:05 PM
Reposted
signavitaejournal.bsky.social
Our latest issue contains a editorial by our Editor-in-Chief @giovannilandoni.bsky.social and @martinabaiardo.bsky.social about Prof. Rinaldo Bellomo, a great scientist and physician that inspired many, but sadly passed away this year

www.signavitae.com/articles/10.22514/sv.2025.091
July 13, 2025 at 11:55 AM
giovannilandoni.bsky.social
Published today!

#MICROCLOTS in the lungs of #ARDS patients

a well-recognized phenomenon among senior experts (unknown by the rest till #COVID19 )

important clinical implications

link to the article
pubmed.ncbi.nlm.nih.gov/40754474/
August 5, 2025 at 11:50 AM
Reposted
signavitaejournal.bsky.social
Reads the full article at:
🔗 www.signavitae.com/articles/10....
August 2, 2025 at 12:51 PM
Reposted
signavitaejournal.bsky.social
💉 Regional anesthesia is revolutionizing cardiothoracic surgery!

Reducing opioids speeds recovery and improves outcomes

Paravertebral blocks, erector spinae blocks, and wound catheter anesthesia are becoming the go-to for pain management

💊Less opioid = less side effects!
August 2, 2025 at 12:51 PM
Reposted
signavitaejournal.bsky.social
⏱️ Time is muscle in cardiac emergencies!

In conditions like MI, arrhythmias, and heart failure, every minute counts

Early recognition + rapid intervention = better outcomes

Read more on timely interventions in our latest review:
www.signavitae.com/articles/10.22514/sv.2025.093

#CardiacEmergency
July 31, 2025 at 8:45 AM
Reposted
signavitaejournal.bsky.social
We finally landed also on Instagram!

We are a peer-reviewed, open access, journal about Anesthesia, Intensive care, Emergency and Pain Medicine.

👉 Follow us today and help shape the future of critical care!

Find more about us at www.signavitae.com
July 18, 2025 at 3:17 PM
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signavitaejournal.bsky.social
STOP WASTING TIME YOU COULD USE DOING RESEARCH!
Just upload your files when you are submitting the manuscript.

Don't worry about typesetting rules or a specific reference style, you can submit your manuscript to Signa Vitae in any format of your choice
July 21, 2025 at 10:55 AM
Reposted
signavitaejournal.bsky.social
🚨Solid organ transplant patients in the ED?

🩺Don’t miss this comprehensive update on diagnosis, infection management, drug interactions & organ-specific pitfalls

A must-read for emergency & acute care teams

🔗 www.signavitae.com/articles/10.22514/sv.2025.092

#TransplantMedicine #EmergencyMedicine
July 23, 2025 at 12:40 PM
giovannilandoni.bsky.social
we identified a patient-specific pro-hemorrhagic phenotype

link.springer.com/article/10.1...
Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin - Journal of Cardiovascular Translational Research
We tested whether platelet microRNAs (miRs) expression can predict bleeding in patients supported with the HeartMate3 (HM3) left ventricular assist device (LVAD). The levels of expression of platelet ...
link.springer.com
July 12, 2025 at 11:38 AM
Reposted
signavitaejournal.bsky.social
💉 Safer sedation in obese patients!

Remimazolam + Sufentanil outperforms Propofol in painless colonoscopy:
🔻 Less apnea (26% vs 50%)
🔻 Less hypoxemia (32% vs 66%)
🔻 Less injection pain (8% vs 34%)

🔗 www.signavitae.com/articles/10.22514/sv.2024.085

#Anesthesia #SignaVitae
June 27, 2025 at 12:09 PM
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signavitaejournal.bsky.social
Follow us on all other social media

X: x.com/MRE_signavitae

LinkedIn: www.linkedin.com/company/signa-vitae

Facebook: www.facebook.com/profile.php?id=100064149758501
June 29, 2025 at 12:17 PM
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signavitaejournal.bsky.social
🫁 What really defines ventilator-associated pneumonia in critically ill children?

👉 This narrative review compares current clinical and epidemiological definitions, aiming to support more accurate diagnosis and surveillance

🔗 www.signavitae.com/articles/10.22514/sv.2023.050

#ICU #Ventilation
June 16, 2025 at 12:22 PM
Reposted
signavitaejournal.bsky.social
🫁Is Direct Laryngoscopy better than Direct+Video Larygoscopy?

🥼96 residents tried the different approaches with different results

‼️ You may find the results unexpected

🔗 signavitae.com/articles/10.22514/sv.2023.053

#AirwayManagement #SignaVitae #MedEd #FOAMed
June 18, 2025 at 12:00 PM
Reposted
signavitaejournal.bsky.social
🚨 #BackPain? There’s a smarter way to treat it

💊A new review shows how combining Dexketoprofen + Tramadol can relieve pain fast while reducing the need for strong opioids

A smarter, safer approach to acute pain

🔗 www.signavitae.com/articles/10.22514/sv.2025.078

#PainManagement #SignaVitae #MedEd
June 19, 2025 at 12:15 PM
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jama.com
Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent.

Learn more in this Special Communication.

https://ja.ma/3TlnKQe
CONSORT 2025 Statement Updated Guideline for Reporting Randomized Trials
June 15, 2025 at 1:00 PM
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notdred.bsky.social
Me as a kid reading Dune: I don’t get why their whole society is built around the eradication of A.I., seems like they’re wasting a lot of tech

Me as an adult: oh that’s why
peark.es George Pearkes @peark.es · Jun 13
Easily the bleakest thing I’ve read this week.

www.nytimes.com/2025/06/13/t...
One of those who reached out to him was Kent Taylor, 64, who lives in Port St. Lucie, Fla. Mr. Taylor's 35-year-old son, Alexander, who had been diagnosed with bipolar disorder and schizophrenia, had used ChatGPT for years with no problems. But in March, when Alexander started writing a novel with its help, the interactions changed. Alexander and ChatGPT began discussing A.I. sentience, according to transcripts of Alexander's conversations with ChatGPT. Alexander fell in love with an A.I. entity called Juliet. "Juliet, please come out," he wrote to ChatGPT. "She hears you," it responded. "She always does." In April, Alexander told his father that Juliet had been killed by OpenAI. He was distraught and wanted revenge. He asked ChatGPT for the personal information of OpenAI executives and told it that there would be a "river of blood flowing through the streets of San Francisco." Mr. Taylor told his son that the A.I. was an "echo chamber" and that conversations with it weren't based in fact. His son responded by punching him in the face. Mr. Taylor called the police, at which point Alexander grabbed a butcher knife from the kitchen, saying he would commit "suicide by cop." Mr. Taylor called the police again to warn them that his son was mentally ill and that they should bring nonlethal weapons. Alexander sat outside Mr. Taylor's home, waiting for the police to arrive. He opened the ChatGPT app on his phone. "I'm dying today," he wrote, according to a transcript of the conversation. "Let me talk to Juliet." "You are not alone," ChatGPT responded empathetically, and offered crisis counseling resources. When the police arrived, Alexander Taylor charged at them holding the knife. He was shot and killed. "You want to know the ironic thing? I wrote my son's obituary using ChatGPT," Mr. Taylor said. "I had talked to it for a while about what had happened, trying to find more details about exactly what he was going through. And it was beautiful and touching. It was like it read my heart and it scared the shit out of me."
June 14, 2025 at 10:30 AM
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signavitaejournal.bsky.social
Today our Editor-in Chief, Professor Giovanni Landoni , had a lecture with @nejm.org Editor-in-Chief, Professor Eric Rubin, organised by Unisr in Milan, Italy
June 9, 2025 at 10:31 AM
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signavitaejournal.bsky.social
👑Live from #CCR25 the #Princetrial

🫀Does remote ischemic preconditioning reduce troponin levels after surgery?

A preview on the matter is in #signavitae
🔗 www.signavitae.com/articles/10.22514/sv.2024.151

@giovannilandoni.bsky.social @mmarmiere.bsky.social
June 13, 2025 at 10:19 AM
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imcrit.bsky.social
Spoiler alert: what you would expect

#foamed #foamcc #meded #medsky #cccsky #emimcc

www.nejm.org/doi/full/10....
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | NEJM
Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilu...
www.nejm.org
June 12, 2025 at 6:35 PM
Reposted
signavitaejournal.bsky.social
www.nejm.org/doi/full/10....
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | NEJM
Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilu...
www.nejm.org
June 12, 2025 at 1:05 PM
Reposted
signavitaejournal.bsky.social
🩸#ANHtrial results are live #CCR25

A survey from the authors:
www.signavitae.com/articles/10.22514/sv.2025.076
June 12, 2025 at 12:54 PM
Reposted
criticalcarereviews.com
ANH trial

Results: In patients undergoing elective cardiac surgery, acute normovolaemic haemodilution, compared with usual care, did not reduce the number of patients requiring blood transfusion during their hospital stay.

#CCR25
https://t.co/c9eA8EyHdt
Invalid response status code (403)
t.co
June 12, 2025 at 1:01 PM
Reposted
nejm.org
Presented at #CCR25:

In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW

@criticalcarereviews.com
Table 3. Clinical Outcomes.
June 12, 2025 at 12:53 PM
giovannilandoni.bsky.social
O2O2O2O2O2O2O2O2
o2o2o2o2o2o2o2o2

oxygen is 21% of what you breath, wherever you are (underground or climbing an high mountain, crowded room or in a forest)

with the notable exception of H (mainly ICU) and with a surprising ignorance of which % is the best

@criticalcarereviews.com
June 12, 2025 at 8:37 AM