Dr. Al
@genedocal.bsky.social
PhD in Genetics, Postdoc at UPenn
Always happy to answer questions about epigenetics and neuroscience.
Hoping to demystify science and break down the ivory tower.
Always happy to answer questions about epigenetics and neuroscience.
Hoping to demystify science and break down the ivory tower.
Post groom pup! He can see again without all the fur over his eyes!
October 9, 2025 at 12:17 PM
Post groom pup! He can see again without all the fur over his eyes!
Representing the apple cup!
September 20, 2025 at 10:17 PM
Representing the apple cup!
Hollow Knight is so good, I wish bugs were real.
September 6, 2025 at 6:15 PM
Hollow Knight is so good, I wish bugs were real.
Read "Ratatouille is a slice of life mecha" an hour ago and I am still reeling.
August 23, 2025 at 1:37 AM
Read "Ratatouille is a slice of life mecha" an hour ago and I am still reeling.
Also almost forgot to shout out this great recent work leveraging functional and transcriptomic neuroscience!
#Scienceadvances #neuroscience
www.science.org/doi/10.1126/...
#Scienceadvances #neuroscience
www.science.org/doi/10.1126/...
A nociceptive amygdala-striatal pathway modulating affective-motivational pain
A nociceptive basolateral amygdala–to–nucleus accumbens shell circuit contributes to pain unpleasantness in chronic pain.
www.science.org
August 16, 2025 at 1:37 PM
Also almost forgot to shout out this great recent work leveraging functional and transcriptomic neuroscience!
#Scienceadvances #neuroscience
www.science.org/doi/10.1126/...
#Scienceadvances #neuroscience
www.science.org/doi/10.1126/...
Doing my miniscule part to signal boost an incredible series fighting against anti-science conspiracy thought.
www.youtube.com/watch?v=uPeU...
www.youtube.com/watch?v=uPeU...
Instagram Reel’s Worst Conspiracy Theorist: Shayne Vibes Truth DEBUNKED - Pt. 1
YouTube video by Miniminuteman
www.youtube.com
August 16, 2025 at 1:32 PM
Doing my miniscule part to signal boost an incredible series fighting against anti-science conspiracy thought.
www.youtube.com/watch?v=uPeU...
www.youtube.com/watch?v=uPeU...
While I am shouting out fresh papers, highlighting this extensive job characterizing Dot1l in neurons and the brain.
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder
Maroni et al. examine the effects of partial loss of the histone lysine methyltransferase DOT1L on neuronal development and function. Using zebrafish and m
academic.oup.com
June 12, 2025 at 10:57 PM
While I am shouting out fresh papers, highlighting this extensive job characterizing Dot1l in neurons and the brain.
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Glad to see this out there and published! Was fun to work in a species that isn't as well characterized as the human or mice!
molmed.biomedcentral.com/articles/10....
molmed.biomedcentral.com/articles/10....
Cellular imbalance in proximal and distal lung of CFTR−/− sheep in utero and at birth - Molecular Medicine
Background The Lung is the major focus of therapeutic approaches for the inherited disorder cystic fibrosis (CF) as without treatment lung disease is life-limiting. However, the initiating events that...
molmed.biomedcentral.com
June 12, 2025 at 10:54 PM
Glad to see this out there and published! Was fun to work in a species that isn't as well characterized as the human or mice!
molmed.biomedcentral.com/articles/10....
molmed.biomedcentral.com/articles/10....
Andor is great and all but I can't wait for the follow-up series about rational operators instead.
GreaterthanEqualto is going to hit.
GreaterthanEqualto is going to hit.
May 7, 2025 at 11:14 PM
Andor is great and all but I can't wait for the follow-up series about rational operators instead.
GreaterthanEqualto is going to hit.
GreaterthanEqualto is going to hit.
Cool preprint! Wonder who spent too much time in illustrator for this.
Autism spectrum disorder risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons https://www.biorxiv.org/content/10.1101/2025.03.25.645337v1
April 4, 2025 at 2:31 AM
Cool preprint! Wonder who spent too much time in illustrator for this.
Signal boosting this project from another postdoc to help spread the word about the economic impacts of the recent research cuts.
Hope this can reach/educate the general public about the enormous damage they have caused and will continue to cause. #SciComm
scienceimpacts.org
Hope this can reach/educate the general public about the enormous damage they have caused and will continue to cause. #SciComm
scienceimpacts.org
SCiMaP
scienceimpacts.org
March 28, 2025 at 11:35 AM
Signal boosting this project from another postdoc to help spread the word about the economic impacts of the recent research cuts.
Hope this can reach/educate the general public about the enormous damage they have caused and will continue to cause. #SciComm
scienceimpacts.org
Hope this can reach/educate the general public about the enormous damage they have caused and will continue to cause. #SciComm
scienceimpacts.org
Imagine if every time you exited any door you entered an assassins creed infinity dimension and had to run around for a bit before the other side loaded
March 23, 2025 at 3:01 AM
Imagine if every time you exited any door you entered an assassins creed infinity dimension and had to run around for a bit before the other side loaded
Reposted by Dr. Al
Check out our new review led by our neuroscience graduate student Anna Voss @annavoss.bsky.social! Anna put together lots of useful tables of these gene families in mouse and human genomes in here. We hope you'll love these H2B genes as much as we do when you read this article!
Research on histone H2B has grown enormously in recent years. Here, Erica Korb (@korblab.bsky.social) and @annavoss.bsky.social discuss H2B genes, proteins, variants, and modifications, and propose a canonical human H2B sequence.
Read for FREE till April 11th:
authors.elsevier.com/a/1keJqcQbJF...
Read for FREE till April 11th:
authors.elsevier.com/a/1keJqcQbJF...
February 24, 2025 at 5:00 PM
Check out our new review led by our neuroscience graduate student Anna Voss @annavoss.bsky.social! Anna put together lots of useful tables of these gene families in mouse and human genomes in here. We hope you'll love these H2B genes as much as we do when you read this article!
Reposted by Dr. Al
A local Rattata made a grave mistake by leading with Tail Whip in a battle he was clearly outmatched in.
paletteswap.site/dif...
paletteswap.site/dif...
February 27, 2025 at 9:33 PM
A local Rattata made a grave mistake by leading with Tail Whip in a battle he was clearly outmatched in.
paletteswap.site/dif...
paletteswap.site/dif...
Okay fine, after all these years, I am going to admit it.
I CAN believe it is not butter
I CAN believe it is not butter
February 22, 2025 at 12:48 AM
Okay fine, after all these years, I am going to admit it.
I CAN believe it is not butter
I CAN believe it is not butter
Friday pup loves all the snow! His first real snow of his life!
February 8, 2025 at 1:52 AM
Friday pup loves all the snow! His first real snow of his life!
Free of cone, embracing the snow, always cute
February 6, 2025 at 12:26 AM
Free of cone, embracing the snow, always cute
My favorite games of 2025, so I can judge my bad taste in the future.
January 24, 2025 at 1:55 PM
My favorite games of 2025, so I can judge my bad taste in the future.
Always the risk of any social media going sour, but #bluesky is so far much, much saner than the alternatives for talking science.
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 12:34 PM
Always the risk of any social media going sour, but #bluesky is so far much, much saner than the alternatives for talking science.
Floofy pup only days away from a much needed grooming.
January 20, 2025 at 5:05 PM
Floofy pup only days away from a much needed grooming.
Great, short read that a lot of academics could benefit from reading I think.
"Scientists come in many forms and can serve society in different ways. It took me a long time to realize that, but I am at peace with it now."
This week's #ScienceWorkingLife: https://scim.ag/3BWd1H2
This week's #ScienceWorkingLife: https://scim.ag/3BWd1H2
January 12, 2025 at 7:49 PM
Great, short read that a lot of academics could benefit from reading I think.
In awe of this art, Nils Hamm does not miss #innistradremastered
January 9, 2025 at 12:19 AM
In awe of this art, Nils Hamm does not miss #innistradremastered
Very good read. I have been wondering that over the last few years as there are SO many atlases out there with exponentially more depth and data.
Researchers have been collaborating on maps of the human body and the subcellular realm. They spoke with Nature Methods about this work and what the future holds for human atlases. 🔒
Atlases galore: where to next? - Nature Methods
Hundreds of researchers collaborate on maps of the human body and the subcellular realm. As they scout out their next mapping expeditions, they take stock of atlas-making.
go.nature.com
January 5, 2025 at 4:22 PM
Very good read. I have been wondering that over the last few years as there are SO many atlases out there with exponentially more depth and data.