Fabian Spill
@fabianspill.bsky.social
Excited by mathematical and computational approaches to studying aging and age-related diseases. Loves interdisciplinary collaborations.
Thanks Craig Blackstone for the news & views @natcellbio.nature.com about our article thats shows how ER shape and mechanics determine the mode of cell migration. Collaboration with Simran, Pradeep and @tamaldastifrh.bsky.social. rdcu.be/eJZWf
ER shaping closes the gap in wound healing
Nature Cell Biology - During wound healing, epithelial gaps trigger curvature-dependent ER remodelling. Tubules form at convex cell edges and promote lamellipodial crawling, whereas ER sheets at...
rdcu.be
October 8, 2025 at 9:37 AM
Thanks Craig Blackstone for the news & views @natcellbio.nature.com about our article thats shows how ER shape and mechanics determine the mode of cell migration. Collaboration with Simran, Pradeep and @tamaldastifrh.bsky.social. rdcu.be/eJZWf
Reposted by Fabian Spill
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Fröhlich Lab | Scientific Machine Learning for Signal Transduction
www.crick.ac.uk
October 7, 2025 at 1:44 PM
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep
The role of contact guidance and ECM remodelling in cancer invasion: a computational study
The extracellular matrix (ECM) is a complex network of fibrous proteins and other macro-molecules that provides crucial mechanical and biochemical cues that regulate cancer cell invasion and tumour pr...
www.biorxiv.org
September 10, 2025 at 7:03 AM
Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep
Reposted by Fabian Spill
RESEARCH | @mic-certo.bsky.social C Mauro et al. (U Birmingham)
Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism
Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
bit.ly
September 9, 2025 at 4:48 PM
RESEARCH | @mic-certo.bsky.social C Mauro et al. (U Birmingham)
Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.
💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.
bit.ly/3HFAQ8S
bit.ly/3HFAQ8S
Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell Biology
Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...
bit.ly
September 8, 2025 at 7:40 PM
Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.
How does the heart age? One challenge to answering this is the lack of available human samples, and another is to integrate different molecular changes. Our paper The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression onlinelibrary.wiley.com/doi/10.1111/... 1/
The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression
A multi-omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machine...
onlinelibrary.wiley.com
September 8, 2025 at 7:51 AM
How does the heart age? One challenge to answering this is the lack of available human samples, and another is to integrate different molecular changes. Our paper The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression onlinelibrary.wiley.com/doi/10.1111/... 1/
Reposted by Fabian Spill
💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.
bit.ly/3HFAQ8S
bit.ly/3HFAQ8S
Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell Biology
Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...
bit.ly
August 25, 2025 at 2:40 PM
💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.
bit.ly/3HFAQ8S
bit.ly/3HFAQ8S
Excited to launch the 1st UK Maths Bio Conference with a freat talk by @tiinaroose.bsky.social on image based modelling of soil
September 4, 2025 at 11:01 AM
Excited to launch the 1st UK Maths Bio Conference with a freat talk by @tiinaroose.bsky.social on image based modelling of soil
Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social to the data analysis of a study in
/@natmetabolism.nature.com
showing how 1/
/@natmetabolism.nature.com
showing how 1/
August 12, 2025 at 8:05 PM
Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social to the data analysis of a study in
/@natmetabolism.nature.com
showing how 1/
/@natmetabolism.nature.com
showing how 1/
Congrats Kylie for publishing her first article from her PhD 'Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds' in @biophysj.bsky.social
www.cell.com/biophysj/abs...
www.cell.com/biophysj/abs...
Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds
Cellular membranes are dynamic, heterogeneous structures where lipid nanodomains (e.g.,
lipid rafts) play key roles in signalling, membrane trafficking, and protein function.
Single-Molecule Localisat...
www.cell.com
August 11, 2025 at 7:39 PM
Congrats Kylie for publishing her first article from her PhD 'Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds' in @biophysj.bsky.social
www.cell.com/biophysj/abs...
www.cell.com/biophysj/abs...
Congrats Margherita for her new paper, where she investigated how cancer spheroids grow in collagen matrices with varying stiffness, implementing varying ECM properties in @physicell.bsky.social Thanks Tom Susan John and Pradeep for the collaboration
www.frontiersin.org/journals/bio...
www.frontiersin.org/journals/bio...
Frontiers | A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening
www.frontiersin.org
April 9, 2025 at 12:41 PM
Congrats Margherita for her new paper, where she investigated how cancer spheroids grow in collagen matrices with varying stiffness, implementing varying ECM properties in @physicell.bsky.social Thanks Tom Susan John and Pradeep for the collaboration
www.frontiersin.org/journals/bio...
www.frontiersin.org/journals/bio...
Reposted by Fabian Spill
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Reposted by Fabian Spill
Meeting at the mathematical modelling/biology interface, in Birmingham in July, organised by @rosemaryjdyson.bsky.social & colleagues.
sites.google.com/view/continu...
🧪🌱🌿
sites.google.com/view/continu...
🧪🌱🌿
Continuum Mechanics in Biology 2025
A three-day workshop addressing the growing interface between
continuum mechanics and the life sciences
sites.google.com
March 12, 2025 at 10:50 AM
Meeting at the mathematical modelling/biology interface, in Birmingham in July, organised by @rosemaryjdyson.bsky.social & colleagues.
sites.google.com/view/continu...
🧪🌱🌿
sites.google.com/view/continu...
🧪🌱🌿
Excited to announce that registration for UK Maths Bio 2025 is open. We have an exciting list of confirmed speakers and are looking for more exciting talks and posters from the community. Please submit your abstract by 31 March 25.
ukmathbioconference.github.io
ukmathbioconference.github.io
UK Mathematical Biology Conference
ukmathbioconference.github.io
February 19, 2025 at 3:54 PM
Excited to announce that registration for UK Maths Bio 2025 is open. We have an exciting list of confirmed speakers and are looking for more exciting talks and posters from the community. Please submit your abstract by 31 March 25.
ukmathbioconference.github.io
ukmathbioconference.github.io
Our new review discusses how mathematical models can help understand the similarities and differences between endothelial and epithelial cells. Thanks
Pradeep, Raul, Maria Jose and
Effie for the collaboration www.cell.com/trends/cell-...
Pradeep, Raul, Maria Jose and
Effie for the collaboration www.cell.com/trends/cell-...
Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology
Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier
function is critical for the maintenance of physiological processes and extremely
sensitive to mechanical cues. Compu...
www.cell.com
January 21, 2025 at 9:21 AM
Our new review discusses how mathematical models can help understand the similarities and differences between endothelial and epithelial cells. Thanks
Pradeep, Raul, Maria Jose and
Effie for the collaboration www.cell.com/trends/cell-...
Pradeep, Raul, Maria Jose and
Effie for the collaboration www.cell.com/trends/cell-...
And congrats @Blaine_VR again, I can't recall I ever had two papers on ArXiv on the same day :) This model is about IBD and identified how mutants and inflammation affect the spread
January 20, 2025 at 6:51 PM
And congrats @Blaine_VR again, I can't recall I ever had two papers on ArXiv on the same day :) This model is about IBD and identified how mutants and inflammation affect the spread
Congrats Blaine for completing the paper 'Eco-evolutionary dynamics of a trait-structured predator-prey model' which features an analytic analysis of a model with population heterogeneity, transient, and long-term dynamics arxiv.org/abs/2501.07379
Eco-evolutionary dynamics of a trait-structured predator-prey model
The coupling between evolutionary and ecological changes (eco-evolutionary dynamics) has been shown to be relevant among diverse species, and is also of interest outside of ecology, i.e. in cancer evo...
arxiv.org
January 20, 2025 at 6:48 PM
Congrats Blaine for completing the paper 'Eco-evolutionary dynamics of a trait-structured predator-prey model' which features an analytic analysis of a model with population heterogeneity, transient, and long-term dynamics arxiv.org/abs/2501.07379
Excited to announce the first UK Maths Bio Conference 4-5 September in Birmingham ukmathbioconference.github.io . Registration will open in a few weeks, save the date! Thanks to my amazing co-organisers Valeria, Kyle, Rachel and Phil for all their work planning the conference.
January 18, 2025 at 12:54 PM
Excited to announce the first UK Maths Bio Conference 4-5 September in Birmingham ukmathbioconference.github.io . Registration will open in a few weeks, save the date! Thanks to my amazing co-organisers Valeria, Kyle, Rachel and Phil for all their work planning the conference.
Congrats Zipeng on completing his paper iTARGET:Interpretable Tailored Age Regression for Grouped Epigenetic Traits arxiv.org/abs/2501.02401
iTARGET: Interpretable Tailored Age Regression for Grouped Epigenetic Traits
Accurately predicting chronological age from DNA methylation patterns is crucial for advancing biological age estimation. However, this task is made challenging by Epigenetic Correlation Drift (ECD) a...
arxiv.org
January 14, 2025 at 9:26 AM
Congrats Zipeng on completing his paper iTARGET:Interpretable Tailored Age Regression for Grouped Epigenetic Traits arxiv.org/abs/2501.02401
Congrats Rico on publishing his article 'Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa'. This paper was motivated to increase global representation in biomedical research. Our collaborators at BMS were specifically interested in t.co/Tj6ShrUoVA 1/
t.co
January 8, 2025 at 10:35 AM
Congrats Rico on publishing his article 'Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa'. This paper was motivated to increase global representation in biomedical research. Our collaborators at BMS were specifically interested in t.co/Tj6ShrUoVA 1/
Still time to apply for positions in Maths @unibirmingham. We hire on every level, from PhD students to prestigious 125 Anniversary Chair positions, deadline early January. Please spread the word! www.systems-mechanobiology.com/jobs
Systems-Mechanobiology - Jobs
www.systems-mechanobiology.com
December 20, 2024 at 10:22 AM
Still time to apply for positions in Maths @unibirmingham. We hire on every level, from PhD students to prestigious 125 Anniversary Chair positions, deadline early January. Please spread the word! www.systems-mechanobiology.com/jobs
I am looking for a postdoc to join our interdisciplinary team developing mechanistic or machine learning systems models of ageing and age-related diseases. One focus is on identifying geometrical and mechanical alterations such as cell and organelle shape changes 1/
December 6, 2024 at 4:22 PM
I am looking for a postdoc to join our interdisciplinary team developing mechanistic or machine learning systems models of ageing and age-related diseases. One focus is on identifying geometrical and mechanical alterations such as cell and organelle shape changes 1/
I am looking for PhD students who love to develop models and ML methods to understand how mechanical, geometrical or metabolic features of cells and tissue change in aging, and how this affects the emergence of age-related diseases. www.findaphd.com/phds/project... www.findaphd.com/phds/project...
Modelling Metabolic Drivers of Ageing and Diseases at University of Birmingham on FindAPhD.com
PhD Project - Modelling Metabolic Drivers of Ageing and Diseases at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
December 5, 2024 at 12:19 PM
I am looking for PhD students who love to develop models and ML methods to understand how mechanical, geometrical or metabolic features of cells and tissue change in aging, and how this affects the emergence of age-related diseases. www.findaphd.com/phds/project... www.findaphd.com/phds/project...
We are looking for a PhD student who is excited about mitochondria and their role in diabetes t.co/Y0fPG459Ad
https://www.findaphd.com/phds/project/preclinical-evaluation-of-mitophagy-inducers-as-a-multisystem-therapy-in-diabetes/?p178844
t.co
November 28, 2024 at 11:30 AM
We are looking for a PhD student who is excited about mitochondria and their role in diabetes t.co/Y0fPG459Ad
We have multiple positions as Assistant and Associate Professor at the University of Birmingham in any area of Mathematics available. Come join our collaborative environment and please spread the word. www.jobs.ac.uk/job/DKT142/a...
Assistant Professor (Research and Education) at University of Birmingham
Explore an exciting academic career as a Assistant Professor (Research and Education). Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
November 25, 2024 at 6:56 PM
We have multiple positions as Assistant and Associate Professor at the University of Birmingham in any area of Mathematics available. Come join our collaborative environment and please spread the word. www.jobs.ac.uk/job/DKT142/a...