Evan Giangrande
@evangiangrande.bsky.social
Postdoc at Broad Institute, Mass General Hospital, & Harvard Med
Psychiatric & Behavioral Genetics | Psychotic Disorders | Cognitive Development | Longitudinal Modeling
Chair of Behavior Genetics Association Public Science Committee
Psychiatric & Behavioral Genetics | Psychotic Disorders | Cognitive Development | Longitudinal Modeling
Chair of Behavior Genetics Association Public Science Committee
Pinned
Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia
Question Is variation in global functioning among people with schizophrenia associated with genetic differences?
Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...
medrxiv.org
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
Reposted by Evan Giangrande
In 2018, Charles Murray challenged me to a bet: "We will understand IQ genetically—I think most of the picture will have been filled in by 2025—there will still be blanks—but we’ll know basically what’s going on." It's now 2025, and I claim a win. I write about it in The Atlantic.
Your Genes Are Simply Not Enough to Explain How Smart You Are
Seven years ago, I took a bet with Charles Murray about whether we’d basically understand the genetics of intelligence by now.
www.theatlantic.com
October 13, 2025 at 1:33 PM
In 2018, Charles Murray challenged me to a bet: "We will understand IQ genetically—I think most of the picture will have been filled in by 2025—there will still be blanks—but we’ll know basically what’s going on." It's now 2025, and I claim a win. I write about it in The Atlantic.
Reposted by Evan Giangrande
Prepping for @dgps.bsky.social Methods, few recent papers pushing ctsem and dynamic models in interesting directions
#1 Developmental changes in twin cognitive correlation (ACE) across age, test instrument, zygosity, with @evangiangrande.bsky.social @ent3c.bsky.social et al
osf.io/preprints/ps...
#1 Developmental changes in twin cognitive correlation (ACE) across age, test instrument, zygosity, with @evangiangrande.bsky.social @ent3c.bsky.social et al
osf.io/preprints/ps...
September 25, 2025 at 9:36 AM
Prepping for @dgps.bsky.social Methods, few recent papers pushing ctsem and dynamic models in interesting directions
#1 Developmental changes in twin cognitive correlation (ACE) across age, test instrument, zygosity, with @evangiangrande.bsky.social @ent3c.bsky.social et al
osf.io/preprints/ps...
#1 Developmental changes in twin cognitive correlation (ACE) across age, test instrument, zygosity, with @evangiangrande.bsky.social @ent3c.bsky.social et al
osf.io/preprints/ps...
Philosophy <--> Science
1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research.
This is wrong.
And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.
This is wrong.
And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.
August 21, 2025 at 2:46 PM
Philosophy <--> Science
This has become my latest pet peeve. "Causal" is sexy and creates the impression that you're uncovering mechanism(s), but "causal estimates" are often just associational and/or reliant on strong assumptions that are rarely met.
E.g., CausalML applied to observational data. Cool, but...
E.g., CausalML applied to observational data. Cool, but...
However, AI folk, it is going to be far, far better if we collectively call "back in time" or "left" in the normal way to lay out time as "antecedent" and *not* causal.
August 20, 2025 at 2:51 PM
This has become my latest pet peeve. "Causal" is sexy and creates the impression that you're uncovering mechanism(s), but "causal estimates" are often just associational and/or reliant on strong assumptions that are rarely met.
E.g., CausalML applied to observational data. Cool, but...
E.g., CausalML applied to observational data. Cool, but...
Check out our preprint on ethical and legal considerations regarding Mendelian Imputation of missing parental genotypes! The method raises tricky questions about informed consent and potential harm. We highlight gaps in current practice and provide recommendations for researchers and IRBs.
New pre-print online: Imputing parental genotypes through Mendelian Imputation: Ethical and Legal Considerations
osf.io/preprints/ps...
osf.io/preprints/ps...
OSF
osf.io
August 15, 2025 at 2:26 PM
Check out our preprint on ethical and legal considerations regarding Mendelian Imputation of missing parental genotypes! The method raises tricky questions about informed consent and potential harm. We highlight gaps in current practice and provide recommendations for researchers and IRBs.
Reposted by Evan Giangrande
I'm happy to share our latest manuscript "Impediments to countering racist pseudoscience", coauthored with @gillianrbrown1.bsky.social @kztwyman.bsky.social & Marcus Feldman.
July 25, 2025 at 9:17 AM
I'm happy to share our latest manuscript "Impediments to countering racist pseudoscience", coauthored with @gillianrbrown1.bsky.social @kztwyman.bsky.social & Marcus Feldman.
Combatting harmful misappropriations of behavioral genetics requires response at multiple levels, including organizational. To that end, the BGA Public Science Committee has released a Statement on the Misuse of Genetics
Our public science committee published its first statement, 'against misuse of behavioral genetics research' on the website.
Read it now on the website ⬇️
bga.org/content.aspx...
Read it now on the website ⬇️
bga.org/content.aspx...
Misuse of Genetics Statement - Behavior Genetics Association
Misuse of Genetics Statement
bga.org
June 20, 2025 at 1:59 PM
Combatting harmful misappropriations of behavioral genetics requires response at multiple levels, including organizational. To that end, the BGA Public Science Committee has released a Statement on the Misuse of Genetics
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia
Question Is variation in global functioning among people with schizophrenia associated with genetic differences?
Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...
medrxiv.org
May 23, 2025 at 3:51 PM
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
Tomorrow!! Check out a great panel on the communication of polygenic score research
The BGA Public Science Committee will co-host Wednesday, May 14th, 11:00 AM-12:00 PM, US Eastern Time, an online symposium addressing how polygenic scores are communicated to the public, challenges of translating this research, and surrounding ethical & legal issues.
Registration: lnkd.in/eGgKgxmT
Registration: lnkd.in/eGgKgxmT
May 13, 2025 at 3:59 PM
Tomorrow!! Check out a great panel on the communication of polygenic score research
Deadline tomorrow!! Already shaping up to be a great issue.
🚨 2 weeks left to submit your abstract for our special issue 🚨
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
Behavior Genetics
link.springer.com
January 30, 2025 at 2:29 PM
Deadline tomorrow!! Already shaping up to be a great issue.
🚨 2 weeks left to submit your abstract for our special issue 🚨
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
Behavior Genetics
link.springer.com
January 15, 2025 at 3:51 PM
🚨 2 weeks left to submit your abstract for our special issue 🚨
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬
We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior
👇👇
link.springer.com/journal/1051...
This is the first I've heard of "palliative psychiatry," a concept that strikes me as equal parts inaccurate, unnecessary, and potentially harmful.
Worth a read for Paul's insightful comments.
Worth a read for Paul's insightful comments.
This report on the effort to characterize psychiatric treatment of some chronic disorders as "palliative care" includes my thoughts on why that's a really bad idea. psychiatryonline.org/doi/10.1176/...
Is There a Role for Palliative Care of Severe and Chronic Mental Disorders? | Psychiatric News
PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.
psychiatryonline.org
January 9, 2025 at 8:36 PM
This is the first I've heard of "palliative psychiatry," a concept that strikes me as equal parts inaccurate, unnecessary, and potentially harmful.
Worth a read for Paul's insightful comments.
Worth a read for Paul's insightful comments.
Reposted by Evan Giangrande
‼️Call for Submissions‼️
Special Issue in @apajournals.bsky.social @scpdiv12.bsky.social CPSP: "The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care"
Email @randimschuster.bsky.social and I with any questions!
docs.google.com/document/d/1...
Special Issue in @apajournals.bsky.social @scpdiv12.bsky.social CPSP: "The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care"
Email @randimschuster.bsky.social and I with any questions!
docs.google.com/document/d/1...
Call for Abstracts: CPSP Special Issue on Nonclinical Providers
Call for Abstracts Special Issue of Clinical Psychology: Science and Practice: The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care Important date...
docs.google.com
January 8, 2025 at 3:49 PM
‼️Call for Submissions‼️
Special Issue in @apajournals.bsky.social @scpdiv12.bsky.social CPSP: "The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care"
Email @randimschuster.bsky.social and I with any questions!
docs.google.com/document/d/1...
Special Issue in @apajournals.bsky.social @scpdiv12.bsky.social CPSP: "The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care"
Email @randimschuster.bsky.social and I with any questions!
docs.google.com/document/d/1...
Reposted by Evan Giangrande
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies
Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...
www.biorxiv.org
December 17, 2024 at 7:05 AM
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Love a cheeky badge ribbon @broadinstitute.org
December 16, 2024 at 5:18 PM
Love a cheeky badge ribbon @broadinstitute.org
Reposted by Evan Giangrande
Reposted by Evan Giangrande
Elsevier is (finally): "reviewing its decision to publish research papers by the late Richard Lynn, an influential figure in the discredited field of “race science” who argued western civilisation was threatened by genetically inferior ethnic groups" www.theguardian.com/science/2024...
Publisher reviews national IQ research by British ‘race scientist’ Richard Lynn
Elsevier investigates journals by scientist who created discredited rankings of countries’ intelligence
www.theguardian.com
December 10, 2024 at 3:55 PM
Elsevier is (finally): "reviewing its decision to publish research papers by the late Richard Lynn, an influential figure in the discredited field of “race science” who argued western civilisation was threatened by genetically inferior ethnic groups" www.theguardian.com/science/2024...
🚨Call for submissions!🚨
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
Call for Submissions: Behavior Genetics Special Issue on Public Science
Call for Submissions: Behavioral Genetics as a Public Science: Impacts and Implications Journal: Behavior Genetics Aim and Scope: Genetically informed studies of human behavior captivate a broad a...
tinyurl.com
December 6, 2024 at 3:17 PM
🚨Call for submissions!🚨
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
Reposted by Evan Giangrande
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Characterizing the genetic architecture of drug response using gene-context interaction methods
Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.
www.cell.com
December 4, 2024 at 8:46 PM
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Reposted by Evan Giangrande
Outreach in psychiatric genetics - What is it? Why do we need it? How can we do it well?
Join me, Niamh Ryan, and Cindy Bulik this Friday (6th) at 10am EST / 4pm CET / 3pm UTC where we'll discuss all of this for the PGC (@pgcgenetics.bsky.social) World Wide Lab 🌎
🔗 us02web.zoom.us/j/88690327502
Join me, Niamh Ryan, and Cindy Bulik this Friday (6th) at 10am EST / 4pm CET / 3pm UTC where we'll discuss all of this for the PGC (@pgcgenetics.bsky.social) World Wide Lab 🌎
🔗 us02web.zoom.us/j/88690327502
December 4, 2024 at 10:24 AM
Outreach in psychiatric genetics - What is it? Why do we need it? How can we do it well?
Join me, Niamh Ryan, and Cindy Bulik this Friday (6th) at 10am EST / 4pm CET / 3pm UTC where we'll discuss all of this for the PGC (@pgcgenetics.bsky.social) World Wide Lab 🌎
🔗 us02web.zoom.us/j/88690327502
Join me, Niamh Ryan, and Cindy Bulik this Friday (6th) at 10am EST / 4pm CET / 3pm UTC where we'll discuss all of this for the PGC (@pgcgenetics.bsky.social) World Wide Lab 🌎
🔗 us02web.zoom.us/j/88690327502
Important 🧵 on explosion in scientific publishing. TLDR: MDPI and its ilk have questionable practices.
I continue to be surprised that this isn’t more widely known/accepted, even among some researchers I respect.
The branding is shiny and legit. The quality is anything but.
I continue to be surprised that this isn’t more widely known/accepted, even among some researchers I respect.
The branding is shiny and legit. The quality is anything but.
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
November 25, 2024 at 9:21 PM
Important 🧵 on explosion in scientific publishing. TLDR: MDPI and its ilk have questionable practices.
I continue to be surprised that this isn’t more widely known/accepted, even among some researchers I respect.
The branding is shiny and legit. The quality is anything but.
I continue to be surprised that this isn’t more widely known/accepted, even among some researchers I respect.
The branding is shiny and legit. The quality is anything but.