Estonian Biobank
@estbiobank.bsky.social
DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.
www.biobank.ee
www.biobank.ee
Welcome to the club! 😎
✅ The UK Government has today granted access to half a million UK Biobank participants' coded GP data for health research.
This change will dramatically increase the power of UK Biobank's dataset to advance the diagnosis, treatment and management of conditions handled by GPs.
This change will dramatically increase the power of UK Biobank's dataset to advance the diagnosis, treatment and management of conditions handled by GPs.
February 11, 2026 at 11:03 AM
Welcome to the club! 😎
Reposted by Estonian Biobank
✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6:
www.nature.com/articles/s41... #Pharmacogenomics @pharmvar.org @clinpgx.org
www.nature.com/articles/s41... #Pharmacogenomics @pharmvar.org @clinpgx.org
February 11, 2026 at 9:23 AM
✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6:
www.nature.com/articles/s41... #Pharmacogenomics @pharmvar.org @clinpgx.org
www.nature.com/articles/s41... #Pharmacogenomics @pharmvar.org @clinpgx.org
Reposted by Estonian Biobank
Seeing one of my favorite projects replicated in another big biobank from another country is an excellent start of the year!
Thank you @iakuznetsov.bsky.social and colleagues (@ukuvainik.bsky.social!) at @estbiobank.bsky.social!
The original @nathumbehav.nature.com paper: rdcu.be/eX5ID
Thread 👇🏾
Thank you @iakuznetsov.bsky.social and colleagues (@ukuvainik.bsky.social!) at @estbiobank.bsky.social!
The original @nathumbehav.nature.com paper: rdcu.be/eX5ID
Thread 👇🏾
Remember the famous UKB migration paper? We found that internal migration also shapes population structure in Estonia. Key patterns replicate within families.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
January 8, 2026 at 6:29 AM
Seeing one of my favorite projects replicated in another big biobank from another country is an excellent start of the year!
Thank you @iakuznetsov.bsky.social and colleagues (@ukuvainik.bsky.social!) at @estbiobank.bsky.social!
The original @nathumbehav.nature.com paper: rdcu.be/eX5ID
Thread 👇🏾
Thank you @iakuznetsov.bsky.social and colleagues (@ukuvainik.bsky.social!) at @estbiobank.bsky.social!
The original @nathumbehav.nature.com paper: rdcu.be/eX5ID
Thread 👇🏾
Reposted by Estonian Biobank
Preprint with the results of genome-wide eQTL analyses across 43,301 blood samples from the eQTLGen Consortium is now online! A major collaborative effort- many thanks to everyone involved, especially @robertwarmerdam.bsky.social, @ludefranke.bsky.social, and all eQTLGen collaborators!👇
🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)
February 6, 2026 at 12:13 PM
Preprint with the results of genome-wide eQTL analyses across 43,301 blood samples from the eQTLGen Consortium is now online! A major collaborative effort- many thanks to everyone involved, especially @robertwarmerdam.bsky.social, @ludefranke.bsky.social, and all eQTLGen collaborators!👇
Reposted by Estonian Biobank
1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
October 16, 2025 at 6:54 PM
1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
Reposted by Estonian Biobank
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Reposted by Estonian Biobank
📢 (on more!) New study from our team in the Journal of Translational Medicine:
Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study
🔗 tinyurl.com/25u3a5j7
(thread below) 👇
Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study
🔗 tinyurl.com/25u3a5j7
(thread below) 👇
Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study - Journal of Translational Medicine
Background Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing ...
translational-medicine.biomedcentral.com
July 3, 2025 at 12:40 PM
📢 (on more!) New study from our team in the Journal of Translational Medicine:
Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study
🔗 tinyurl.com/25u3a5j7
(thread below) 👇
Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study
🔗 tinyurl.com/25u3a5j7
(thread below) 👇
Reposted by Estonian Biobank
🎉(1/4) Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank - European Journal of Human Genetics
European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank
www.nature.com
July 2, 2025 at 8:47 AM
🎉(1/4) Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
Reposted by Estonian Biobank
A study in Nature Medicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. https://go.nature.com/3G6slSR 🔒
April 7, 2025 at 1:19 PM
A study in Nature Medicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. https://go.nature.com/3G6slSR 🔒
Reposted by Estonian Biobank
Excited to share our recently published overview of the @estbiobank.bsky.social 🧬
We highlight the unique features of the biobank and the conducted scientific research it has enabled, including the many recall studies that have been carried out over the years!
www.nature.com/articles/s41...
We highlight the unique features of the biobank and the conducted scientific research it has enabled, including the many recall studies that have been carried out over the years!
www.nature.com/articles/s41...
The Estonian Biobank’s journey from biobanking to personalized medicine - Nature Communications
Large-scale biobanks have become a font of data that have led to discoveries across many fields of research. Here, the authors provide an overview of the Estonian Biobank, highlighting its value for r...
www.nature.com
April 7, 2025 at 9:13 AM
Excited to share our recently published overview of the @estbiobank.bsky.social 🧬
We highlight the unique features of the biobank and the conducted scientific research it has enabled, including the many recall studies that have been carried out over the years!
www.nature.com/articles/s41...
We highlight the unique features of the biobank and the conducted scientific research it has enabled, including the many recall studies that have been carried out over the years!
www.nature.com/articles/s41...
Reposted by Estonian Biobank
💡Can we use real world drug purchase data to study the genetics of medication dosing?
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 doi.org/10.1101/2025...
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 doi.org/10.1101/2025...
Investigating the genetic factors of medication dosing using biobank-linked drug purchase data
Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electronic health records...
doi.org
April 4, 2025 at 11:50 AM
💡Can we use real world drug purchase data to study the genetics of medication dosing?
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 doi.org/10.1101/2025...
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 doi.org/10.1101/2025...
Reposted by Estonian Biobank
Our popular SPE-course is coming again! Boost your epidemiology & stats skills in R! Join "Statistical Practice in Epidemiology using R" at the University of Tartu, Estonia, June 2–6, 2025. More info: bendixcarstensen.com/SPE/
SPE Tartu 2025
bendixcarstensen.com
March 19, 2025 at 8:26 AM
Our popular SPE-course is coming again! Boost your epidemiology & stats skills in R! Join "Statistical Practice in Epidemiology using R" at the University of Tartu, Estonia, June 2–6, 2025. More info: bendixcarstensen.com/SPE/
Reposted by Estonian Biobank
Happy to share our recent article on metabolomics and incident hypertension in the Estonian Biobank. @kristafi.bsky.social @estbiobank.bsky.social @urmovosa.bsky.social
rdcu.be/edbUZ
rdcu.be/edbUZ
Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank
Scientific Reports - Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank
rdcu.be
March 20, 2025 at 6:59 AM
Happy to share our recent article on metabolomics and incident hypertension in the Estonian Biobank. @kristafi.bsky.social @estbiobank.bsky.social @urmovosa.bsky.social
rdcu.be/edbUZ
rdcu.be/edbUZ
Reposted by Estonian Biobank
📢 Excited to share our study in @natmedicine.bsky.social
👉 www.nature.com/articles/s41...
We mapped & characterized genetic risk factors for 42 female reproductive health diagnoses. What we found & why it matters? 👇🧵
👉 www.nature.com/articles/s41...
We mapped & characterized genetic risk factors for 42 female reproductive health diagnoses. What we found & why it matters? 👇🧵
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses - Nature Medicine
This study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.
www.nature.com
March 17, 2025 at 9:27 AM
📢 Excited to share our study in @natmedicine.bsky.social
👉 www.nature.com/articles/s41...
We mapped & characterized genetic risk factors for 42 female reproductive health diagnoses. What we found & why it matters? 👇🧵
👉 www.nature.com/articles/s41...
We mapped & characterized genetic risk factors for 42 female reproductive health diagnoses. What we found & why it matters? 👇🧵
Reposted by Estonian Biobank
📣 New blog post on our recent paper on #ADHD genetic liability and health outcomes in people without diagnosed ADHD! @timespan-h2020.bsky.social @estbiobank.bsky.social
Recent research @estbiobank.bsky.social revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%), & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!
January 24, 2025 at 8:11 AM
📣 New blog post on our recent paper on #ADHD genetic liability and health outcomes in people without diagnosed ADHD! @timespan-h2020.bsky.social @estbiobank.bsky.social
Reposted by Estonian Biobank
It's been a busy December, so I'm only just getting around to sharing our publication on metabolomic and genomic prediction of common diseases in 3 national biobanks. A few highlights in the 🧵! www.nature.com/articles/s41...
www.nature.com
December 20, 2024 at 8:29 AM
It's been a busy December, so I'm only just getting around to sharing our publication on metabolomic and genomic prediction of common diseases in 3 national biobanks. A few highlights in the 🧵! www.nature.com/articles/s41...
Reposted by Estonian Biobank
🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025!
This prestigious summer school brings together leaders in human genetics with PhD students
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
This prestigious summer school brings together leaders in human genetics with PhD students
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
LPSHG – Leena Peltonen Shool Of Human Genomics
www.lpshg.com
December 19, 2024 at 4:01 PM
🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025!
This prestigious summer school brings together leaders in human genetics with PhD students
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
This prestigious summer school brings together leaders in human genetics with PhD students
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
Reposted by Estonian Biobank
🦠 Excited to share our new collection of human gut #archaea species! 🎉
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut
December 12, 2024 at 10:19 AM
🦠 Excited to share our new collection of human gut #archaea species! 🎉
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut
Reposted by Estonian Biobank
This is what happens when you return research results to biobank participants:
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
December 13, 2024 at 10:28 AM
This is what happens when you return research results to biobank participants:
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
Reposted by Estonian Biobank
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...
www.medrxiv.org
December 6, 2024 at 12:12 PM
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Reposted by Estonian Biobank
New preprint out on genetic susceptibility to infection with Omicron variants of SARS-CoV-2. International GWAS meta-analysis discovers loci not found for earlier variants of the virus and indicates central role of glycosylation.
👇
www.medrxiv.org/content/10.1...
👇
www.medrxiv.org/content/10.1...
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants
The host genetics of SARS-CoV-2 has previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and/or severit...
www.medrxiv.org
November 22, 2024 at 2:59 PM
New preprint out on genetic susceptibility to infection with Omicron variants of SARS-CoV-2. International GWAS meta-analysis discovers loci not found for earlier variants of the virus and indicates central role of glycosylation.
👇
www.medrxiv.org/content/10.1...
👇
www.medrxiv.org/content/10.1...