Thomas Elbenhardt Jensen
@elbenhardt.bsky.social
Professor in Molecular Exercise Physiology at NEXS, UCPH, DK. Main interest is striated muscle growth and metabolism.
In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Muscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism
Abstract figure legend This study investigated the role of AXIN1 and AXIN2 in regulating skeletal muscle AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) sig....
physoc.onlinelibrary.wiley.com
July 1, 2025 at 5:34 AM
In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Thomas Elbenhardt Jensen
Latest from Jonas Treebak and team @cbmr.science
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…
www.sciencedirect.com
April 30, 2025 at 3:49 PM
Latest from Jonas Treebak and team @cbmr.science
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
Reposted by Thomas Elbenhardt Jensen
Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩
Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle
The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…
www.sciencedirect.com
March 27, 2025 at 7:34 AM
Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩
Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle
The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…
www.sciencedirect.com
March 26, 2025 at 6:00 PM
Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Thomas Elbenhardt Jensen
“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).
www.sciencedirect.com/science/arti...
3/17
www.sciencedirect.com/science/arti...
3/17
Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison
Striated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…
www.sciencedirect.com
January 30, 2025 at 7:33 AM
“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).
www.sciencedirect.com/science/arti...
3/17
www.sciencedirect.com/science/arti...
3/17
Reposted by Thomas Elbenhardt Jensen
🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social at our DZD-Partne#DIfEfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 21, 2025 at 2:37 PM
🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social at our DZD-Partne#DIfEfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️
Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...
mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity
mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....
faseb.onlinelibrary.wiley.com
January 21, 2025 at 7:06 PM
Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...
Reposted by Thomas Elbenhardt Jensen
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 6, 2025 at 2:44 PM
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Reposted by Thomas Elbenhardt Jensen
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 3, 2025 at 6:10 PM
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Thomas Elbenhardt Jensen
A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature Communications
This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...
doi.org
December 19, 2024 at 4:43 PM
A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
Reposted by Thomas Elbenhardt Jensen
🌟 ICYMI: Altmetric now tracks Bluesky mentions!
✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions
Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...
#AcademicSky
✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions
Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...
#AcademicSky
Tapping into data from Bluesky
Altmetric has expanded its tracking capabilities by integrating data from Bluesky, the rapidly growing social media platform with over 24 million users.
www.altmetric.com
December 10, 2024 at 8:00 AM
🌟 ICYMI: Altmetric now tracks Bluesky mentions!
✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions
Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...
#AcademicSky
✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions
Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...
#AcademicSky
Reposted by Thomas Elbenhardt Jensen
New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes
#myoblue #exercise #metabolism
www.nature.com/articles/s41...
#myoblue #exercise #metabolism
www.nature.com/articles/s41...
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus - Nature Reviews Endocrinology
This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, as well as highlighting current research gaps within the field. These discussi...
www.nature.com
November 27, 2024 at 3:05 PM
New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes
#myoblue #exercise #metabolism
www.nature.com/articles/s41...
#myoblue #exercise #metabolism
www.nature.com/articles/s41...
Reposted by Thomas Elbenhardt Jensen
November 22, 2024 at 1:14 PM
Reposted by Thomas Elbenhardt Jensen
Let’s try out this new platform by sharing our recent paper on the transcriptional signatures of individual muscle fibers following high-intensity exercise
#myoblue #myosky
journals.physiology.org/doi/abs/10.1...
#myoblue #myosky
journals.physiology.org/doi/abs/10.1...
November 18, 2024 at 7:56 PM
Let’s try out this new platform by sharing our recent paper on the transcriptional signatures of individual muscle fibers following high-intensity exercise
#myoblue #myosky
journals.physiology.org/doi/abs/10.1...
#myoblue #myosky
journals.physiology.org/doi/abs/10.1...
Reposted by Thomas Elbenhardt Jensen
Neither the conference organisers nor the artist are (yet) on here but look at this amazing live drawn summary of my #MetabolismInAction paper by Eleonora Nigro #HistSTM #PolarHistory
November 20, 2024 at 9:00 AM
Neither the conference organisers nor the artist are (yet) on here but look at this amazing live drawn summary of my #MetabolismInAction paper by Eleonora Nigro #HistSTM #PolarHistory