Maximilian Kleinert
@mkleinert.bsky.social
Researcher interested in metabolism, nutrition, energy balance. Head of Molecular Physiology of Exercise and Nutrition Department @Leibniz_Dife. Views are my own.
Pinned
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Reposted by Maximilian Kleinert
🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social at our DZD-Partne#DIfEfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 21, 2025 at 2:37 PM
🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social at our DZD-Partne#DIfEfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️
Reposted by Maximilian Kleinert
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing!
👇
www.cell.com/cell-reports...
👇
www.cell.com/cell-reports...
January 19, 2025 at 11:37 AM
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing!
👇
www.cell.com/cell-reports...
👇
www.cell.com/cell-reports...
Reposted by Maximilian Kleinert
Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)
Time-resolved effects of short-term overfeeding on energy balance in mice
To curb the obesity epidemic, it is imperative that we improve our understanding of the mechanisms controlling fat mass and body weight regulation. While g
diabetesjournals.org
January 12, 2025 at 7:04 PM
Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)
Reposted by Maximilian Kleinert
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail
While total RNA concentrations putatively represent ribosome content, there is a need to homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) provided through UV–Vis s...
physoc.onlinelibrary.wiley.com
January 9, 2025 at 9:28 PM
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
Shamelessly😬 reposting our recent work to a broader metabolism network—thanks to @frezzalab.bsky.social starter packs. We’d love to hear your thoughts!
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 8, 2025 at 1:17 PM
Shamelessly😬 reposting our recent work to a broader metabolism network—thanks to @frezzalab.bsky.social starter packs. We’d love to hear your thoughts!
Reposted by Maximilian Kleinert
With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it.
go.bsky.app/7Uwa6fb
go.bsky.app/7Uwa6fb
January 7, 2025 at 1:54 PM
With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it.
go.bsky.app/7Uwa6fb
go.bsky.app/7Uwa6fb
Reposted by Maximilian Kleinert
Why Is the American Diet So Deadly?
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
@DhruvKhullar
www.newyorker.com/magazine/202...
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
@DhruvKhullar
www.newyorker.com/magazine/202...
Why Is the American Diet So Deadly?
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
www.newyorker.com
January 6, 2025 at 4:44 PM
Why Is the American Diet So Deadly?
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
@DhruvKhullar
www.newyorker.com/magazine/202...
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
@DhruvKhullar
www.newyorker.com/magazine/202...
Reposted by Maximilian Kleinert
NEW ISSUE! We start 2025 approaching gut-brain crosstalk from a variety of perspectives, including neuroendocrine regulation of gut-brain signaling, interaction between microbiome and circadian rhythms, microbial metabolites associated with gut health and the potential of microbiome-based therapies.
January 6, 2025 at 3:59 PM
NEW ISSUE! We start 2025 approaching gut-brain crosstalk from a variety of perspectives, including neuroendocrine regulation of gut-brain signaling, interaction between microbiome and circadian rhythms, microbial metabolites associated with gut health and the potential of microbiome-based therapies.
Reposted by Maximilian Kleinert
A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...
Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1
<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.
physoc.onlinelibrary.wiley.com
January 6, 2025 at 7:44 PM
A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 6, 2025 at 2:44 PM
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue