David McKellar
@dwmckellar.bsky.social
RNA Tech Dev
Romix Bio | Tech Inno @ NYGC | PhD @ Cornell BME | postbac @ NHGRI
mckellardw.github.io
Romix Bio | Tech Inno @ NYGC | PhD @ Cornell BME | postbac @ NHGRI
mckellardw.github.io
Still time to sign up for this event next week!
So far, across the ~120 registrants we have 7 academic institutions, 4 companies, and 2 journals represented!
So far, across the ~120 registrants we have 7 academic institutions, 4 companies, and 2 journals represented!
Very excited to announce the first **RNA x Tech Dev Mini-Symposium** in collab with the Tri-I RNA Club!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
June 2, 2025 at 1:27 PM
Still time to sign up for this event next week!
So far, across the ~120 registrants we have 7 academic institutions, 4 companies, and 2 journals represented!
So far, across the ~120 registrants we have 7 academic institutions, 4 companies, and 2 journals represented!
Not a bad spot to talk science...
May 18, 2025 at 6:47 AM
Not a bad spot to talk science...
Very excited to announce the first **RNA x Tech Dev Mini-Symposium** in collab with the Tri-I RNA Club!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
May 6, 2025 at 1:31 PM
Very excited to announce the first **RNA x Tech Dev Mini-Symposium** in collab with the Tri-I RNA Club!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
Talks from Chris Mason, Ildar Gainetdinov,
@xuebingwu.bsky.social, and Sanja Vickovic!
Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!
A window into the future of diagnostics from one of my favorite scientists, @alexpellancheng.bsky.social. Awesome work!
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling
Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.
rdcu.be
April 11, 2025 at 4:26 PM
A window into the future of diagnostics from one of my favorite scientists, @alexpellancheng.bsky.social. Awesome work!
Very cool work from the team at Kanvas on HiPR-Map!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multiscale Spatial Mapping of Microbial Communities for Biotherapeutic Development
Live biotherapeutic products (LBPs) are emerging as powerful tools to modulate the microbiome using well-defined microbial communities. Yet, designing, manufacturing, and delivering LBPs remains chall...
www.biorxiv.org
April 2, 2025 at 1:28 PM
Very cool work from the team at Kanvas on HiPR-Map!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Designing/building a Toyota is just as hard as a designing/building Ferrari in biology
Many highly cited experimental methods are methods that sound useful but hard/impossible to implement successfully. Many highly cited computational studies are for methods that have implementation but actually don't work well (or are just slow), giving an excellent benchmark for others.
February 20, 2025 at 2:36 PM
Designing/building a Toyota is just as hard as a designing/building Ferrari in biology
Reposted by David McKellar
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
January 16, 2025 at 4:27 AM
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
Reposted by David McKellar
And without further ado, the top muscle paper for 2024 as voted on by you is: 1. Sequeira et al., Dev. Myonuclear position and blood vessel organization during skeletal muscle postnatal development. tinyurl.com/bduvtpa8
Myonuclear position and blood vessel organization during skeletal muscle postnatal development
Summary: A comprehensive analysis of the first 20 days of mouse skeletal muscle postnatal development focusing on myonuclear positioning and interactions of myonuclei with blood vessels.
tinyurl.com
December 31, 2024 at 1:24 PM
And without further ado, the top muscle paper for 2024 as voted on by you is: 1. Sequeira et al., Dev. Myonuclear position and blood vessel organization during skeletal muscle postnatal development. tinyurl.com/bduvtpa8
Reposted by David McKellar
Delighted to share new work from our lab:
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology
MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.
go.nature.com
November 26, 2024 at 1:42 PM
Delighted to share new work from our lab:
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Come talk RNA with us!
#RNA enthusiasts in the NYC area? Come join us for the Tri-I RNA Club Winter Mini-Symposium! We’ll have great talks by trainees, followed by some food and drinks. Hope to see you there!
#RNAsky #RNAbiology
#RNAsky #RNAbiology
November 26, 2024 at 8:25 PM
Come talk RNA with us!
Reposted by David McKellar
Spatial structure shapes the host-microbiome interactome.
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing
Inter–microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few tools are available to measure these interactions. Here, we report a metho...
doi.org
November 19, 2024 at 11:12 PM
Spatial structure shapes the host-microbiome interactome.
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️