Yannis Ntekas
@ntekasi.bsky.social
PhD student at CornellBME/DeVlaminckLab. Spatial omics/microbiome
Reposted by Yannis Ntekas
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
open.substack.com
November 19, 2025 at 5:12 PM
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
Reposted by Yannis Ntekas
Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology
Profiling host RNA shed in feces reveals disease states in the gut.
www.nature.com
November 17, 2025 at 8:55 PM
Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yannis Ntekas
Another banger from the @harriswang.bsky.social Lab this month!
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology
Profiling host RNA shed in feces reveals disease states in the gut.
www.nature.com
November 18, 2025 at 12:59 AM
Another banger from the @harriswang.bsky.social Lab this month!
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...
Reposted by Yannis Ntekas
Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature
Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...
www.nature.com
March 11, 2025 at 11:22 PM
Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yannis Ntekas
Contributions from: Jeffrey Moffitt, @drmingyaoli.bsky.social, Qing Nie, Kazumasa Kanemaru, Sarah Teichmann, Daniel Dar, @ltkagohara.bsky.social, Shalev Itzkovitz, Roser Vento-Tormo, @fertiglab.bsky.social, @fabiantheis.bsky.social
February 23, 2025 at 5:39 PM
Contributions from: Jeffrey Moffitt, @drmingyaoli.bsky.social, Qing Nie, Kazumasa Kanemaru, Sarah Teichmann, Daniel Dar, @ltkagohara.bsky.social, Shalev Itzkovitz, Roser Vento-Tormo, @fertiglab.bsky.social, @fabiantheis.bsky.social
Reposted by Yannis Ntekas
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from m
www.biorxiv.org
December 4, 2024 at 1:31 PM
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1
Reposted by Yannis Ntekas
New research from the Xavier lab at Broad reveals the gut's adaptability and immune-driven control in specific regions. A spatial map of the mouse intestines highlights its resilience to perturbations like inflammation, with implications for understanding diet, food allergies, and IBD in humans 🧬🦠
The intestine maintains a delicate balance in the body. This equilibrium is disrupted in parts of the organ in some diseases, but scientists don’t fully understand why. Now, researchers have created a blueprint of the gut that could address these questions. #science @natureportfolio.bsky.social
Scientists find a region of the mouse gut tightly regulated by the immune system
A spatial map of gene expression across the intestine reveals the organ’s remarkable adaptability.
www.broadinstitute.org
November 21, 2024 at 3:12 PM
New research from the Xavier lab at Broad reveals the gut's adaptability and immune-driven control in specific regions. A spatial map of the mouse intestines highlights its resilience to perturbations like inflammation, with implications for understanding diet, food allergies, and IBD in humans 🧬🦠
Spatial structure shapes the host-microbiome interactome.
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing
Inter–microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few tools are available to measure these interactions. Here, we report a metho...
doi.org
November 19, 2024 at 11:12 PM
Spatial structure shapes the host-microbiome interactome.
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️
Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv!
Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs
doi.org/10.1101/2024...
A thread⬇️