Chuan Chen, MD PhD
@drchuanchen.bsky.social
🔬 PGY2 AP/CP resident @ Mayo Clinic
🩸 #Pathology #Hemepath
🧬 #MDS #Lymphoma #NGS
📚@CAPA Online Education
📺 YouTuber https://youtube.com/@dr.chuanchen
🎓@UnivMiami @NimerLab alumnus
🏃🏻🏃🏻Hiking 🪴🪴Planting
🩸 #Pathology #Hemepath
🧬 #MDS #Lymphoma #NGS
📚@CAPA Online Education
📺 YouTuber https://youtube.com/@dr.chuanchen
🎓@UnivMiami @NimerLab alumnus
🏃🏻🏃🏻Hiking 🪴🪴Planting
Pinned
Case 1. Hyaline vascular Castleman disease stromal rich variant with iTdT+ proliferation
YouTube video by Chuan Chen, MD PhD
youtu.be
Kicking off 2025 with my second YouTube series: Hematopathology Case Collection. The first case explores hyaline vascular Castleman Disease, stromal-rich variant with indolent T-lymphoblastic proliferation. Check it out here: youtu.be/T_1ByEJeWXM?...
Reposted by Chuan Chen, MD PhD
FNA of solid pancreatic head mass.
What do these cells represent?🧐🧐
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
What do these cells represent?🧐🧐
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
April 20, 2025 at 1:34 PM
FNA of solid pancreatic head mass.
What do these cells represent?🧐🧐
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
What do these cells represent?🧐🧐
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
Reposted by Chuan Chen, MD PhD
#slidearchiveseries history of DLBCL s/p chemotherapy with residual retroperitoneal lymphadenopathy, s/p radiation therapy for bulky cauda equina leptomeningeal disease, now for management of prostate abscess #gupath #malakoplakia
March 29, 2025 at 2:35 PM
#slidearchiveseries history of DLBCL s/p chemotherapy with residual retroperitoneal lymphadenopathy, s/p radiation therapy for bulky cauda equina leptomeningeal disease, now for management of prostate abscess #gupath #malakoplakia
Reposted by Chuan Chen, MD PhD
Sharing our sincere appreciation and gratitude for our #Pathology residents & fellows! Thank you for your unwavering dedication and invaluable contributions to our special learning community 😊🙌
February 28, 2025 at 10:16 PM
Sharing our sincere appreciation and gratitude for our #Pathology residents & fellows! Thank you for your unwavering dedication and invaluable contributions to our special learning community 😊🙌
Reposted by Chuan Chen, MD PhD
We can't wait to see everyone this weekend at #USCAP2025! Getting excited for Boston!
March 19, 2025 at 10:08 PM
We can't wait to see everyone this weekend at #USCAP2025! Getting excited for Boston!
Reposted by Chuan Chen, MD PhD
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
March 18, 2025 at 6:40 PM
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
Reposted by Chuan Chen, MD PhD
#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?
February 5, 2025 at 6:57 PM
#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?
Reposted by Chuan Chen, MD PhD
#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.
February 5, 2025 at 7:08 PM
#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.
Reposted by Chuan Chen, MD PhD
#PathSky Older adult with a large, prolapsing esophageal mass. An excellent example of a “giant fibrovascular polyp” of the esophagus. Except that essentially 100% of these turn out to be well-differentiated ( or less often dedifferentiated) liposarcomas.
pubmed.ncbi.nlm.nih.gov/28984298/
pubmed.ncbi.nlm.nih.gov/28984298/
January 24, 2025 at 8:37 PM
#PathSky Older adult with a large, prolapsing esophageal mass. An excellent example of a “giant fibrovascular polyp” of the esophagus. Except that essentially 100% of these turn out to be well-differentiated ( or less often dedifferentiated) liposarcomas.
pubmed.ncbi.nlm.nih.gov/28984298/
pubmed.ncbi.nlm.nih.gov/28984298/
Kicking off 2025 with my second YouTube series: Hematopathology Case Collection. The first case explores hyaline vascular Castleman Disease, stromal-rich variant with indolent T-lymphoblastic proliferation. Check it out here: youtu.be/T_1ByEJeWXM?...
Case 1. Hyaline vascular Castleman disease stromal rich variant with iTdT+ proliferation
YouTube video by Chuan Chen, MD PhD
youtu.be
January 5, 2025 at 9:15 PM
Kicking off 2025 with my second YouTube series: Hematopathology Case Collection. The first case explores hyaline vascular Castleman Disease, stromal-rich variant with indolent T-lymphoblastic proliferation. Check it out here: youtu.be/T_1ByEJeWXM?...
Reposted by Chuan Chen, MD PhD
#PathSky This one definitely needs more than 4 images, so go to the Comments too. 65F, iliac crest lesion. The original pathologists quite reasonably considered an epithelioid hemangioendothelioma, although it was CAMTA1-negative.
December 23, 2024 at 10:45 PM
#PathSky This one definitely needs more than 4 images, so go to the Comments too. 65F, iliac crest lesion. The original pathologists quite reasonably considered an epithelioid hemangioendothelioma, although it was CAMTA1-negative.
Reposted by Chuan Chen, MD PhD
Just learned about bluesky! For a first post, here is an image of ductal type prostate cancer. Diagnostic criteria can be controversial but common features are columnar cells and papillary structures. Typically considered grade 4. #GUpath
December 12, 2024 at 4:25 PM
Just learned about bluesky! For a first post, here is an image of ductal type prostate cancer. Diagnostic criteria can be controversial but common features are columnar cells and papillary structures. Typically considered grade 4. #GUpath
Reposted by Chuan Chen, MD PhD
Some tumor look-a-likes on this Friday:
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
December 6, 2024 at 5:46 PM
Some tumor look-a-likes on this Friday:
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Reposted by Chuan Chen, MD PhD
Kidney pathology in an autopsy case for decompensated cirrhosis. Patchy bile cast nephropathy (brown casts; green on Hall's bile stain) and a Randall plaque (papillary tip nephrocalcinosis). #renalpath #nephrology #pathsky #nephsky
November 30, 2024 at 4:29 PM
Kidney pathology in an autopsy case for decompensated cirrhosis. Patchy bile cast nephropathy (brown casts; green on Hall's bile stain) and a Randall plaque (papillary tip nephrocalcinosis). #renalpath #nephrology #pathsky #nephsky
Reposted by Chuan Chen, MD PhD
Central Zone glands #prostate #gupath #PathSky
🌉complex architecture
🌉stratified eosinophilic cytoplasm
🌉prominent basal cell layer
🌉intra-luminal bridges ("Roman arches")
🌉mimic high grade PIN
🌉Rule of👍🏻: in NB from mid gland-base, have higher threshold for diagnosing HGPIN & r/o normal anatomy!
🌉complex architecture
🌉stratified eosinophilic cytoplasm
🌉prominent basal cell layer
🌉intra-luminal bridges ("Roman arches")
🌉mimic high grade PIN
🌉Rule of👍🏻: in NB from mid gland-base, have higher threshold for diagnosing HGPIN & r/o normal anatomy!
November 27, 2024 at 2:49 PM
Reposted by Chuan Chen, MD PhD
#PathSky
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
November 21, 2024 at 8:08 PM
#PathSky
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Reposted by Chuan Chen, MD PhD
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
November 22, 2024 at 2:48 PM
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
Reposted by Chuan Chen, MD PhD
#PathSky
I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?
I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?
November 20, 2024 at 6:01 PM
#PathSky
I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?
I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?
Reposted by Chuan Chen, MD PhD
November 20, 2024 at 2:25 PM
Reposted by Chuan Chen, MD PhD
Vegetable matter as seen in a fatal case of aspiration pneumonia 🔬
#thingsthatkill #autopsy #microscopy #PathSky #MedSky
#thingsthatkill #autopsy #microscopy #PathSky #MedSky
November 20, 2024 at 3:41 PM
Vegetable matter as seen in a fatal case of aspiration pneumonia 🔬
#thingsthatkill #autopsy #microscopy #PathSky #MedSky
#thingsthatkill #autopsy #microscopy #PathSky #MedSky
Reposted by Chuan Chen, MD PhD
Ok, my third attempt at a first post. I like surgical pathology and sharing cases.
New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet.
pubmed.ncbi.nlm.nih.gov/38866368/
#PathSky
New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet.
pubmed.ncbi.nlm.nih.gov/38866368/
#PathSky
November 20, 2024 at 12:55 AM
Ok, my third attempt at a first post. I like surgical pathology and sharing cases.
New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet.
pubmed.ncbi.nlm.nih.gov/38866368/
#PathSky
New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet.
pubmed.ncbi.nlm.nih.gov/38866368/
#PathSky
Reposted by Chuan Chen, MD PhD
Hybrid tumor: Oncocytoma and Chromophobe Renal cell Carcinoma! #GUpathsky #pathsky #pathology #surgicalpathology #pathart #Nephsky
November 20, 2024 at 12:18 AM
Hybrid tumor: Oncocytoma and Chromophobe Renal cell Carcinoma! #GUpathsky #pathsky #pathology #surgicalpathology #pathart #Nephsky
Reposted by Chuan Chen, MD PhD
Ameloblastoma (follicular type), mandible, H&Es, 20x and 40x: Epithelial nests with a peripheral layer of columnar cells showing "palisading" and "reverse polarity", surrounding a central area resembling the “stellate reticulum” of a developing tooth! #pathology #pathsky #surgicalpathology #pathart
November 20, 2024 at 3:29 AM
Ameloblastoma (follicular type), mandible, H&Es, 20x and 40x: Epithelial nests with a peripheral layer of columnar cells showing "palisading" and "reverse polarity", surrounding a central area resembling the “stellate reticulum” of a developing tooth! #pathology #pathsky #surgicalpathology #pathart
Reposted by Chuan Chen, MD PhD
Chromophobe renal cell carcinoma (ChRCC), kidney, H&Es, 20x and 40x, CK7, 20x: Plant-like tumor cells - Vimentin negative; CK7 and C-Kit positive!
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart
November 18, 2024 at 10:35 PM
Chromophobe renal cell carcinoma (ChRCC), kidney, H&Es, 20x and 40x, CK7, 20x: Plant-like tumor cells - Vimentin negative; CK7 and C-Kit positive!
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart
Reposted by Chuan Chen, MD PhD
Columbia Virology course by Vincent Racaniello for free on youtube youtube.com/watch?v=GEC3...
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November 16, 2024 at 7:51 PM
Columbia Virology course by Vincent Racaniello for free on youtube youtube.com/watch?v=GEC3...