Dr. David Boulware, MD MPH
@drboulware.bsky.social
Professor of Medicine at U of MN; Practicing infectious disease doc; budding mycologist; interested in cryptococcal & TB meningitis. Ran some RCTs during COVID, but more excited to return to focus on RCTs on HIV-related meningitis & advanced HIV disease
Reposted by Dr. David Boulware, MD MPH
✅ 2025: Victories for disease control! The world scored major victories for disease control and elimination.
🥳 Maldives became the first country to achieve “triple elimination” of mother-to-child transmission of HIV, syphilis and hepatitis B.
🥳 Burundi, Egypt and Fiji eliminated trachoma.
🥳 Maldives became the first country to achieve “triple elimination” of mother-to-child transmission of HIV, syphilis and hepatitis B.
🥳 Burundi, Egypt and Fiji eliminated trachoma.
December 24, 2025 at 7:20 PM
✅ 2025: Victories for disease control! The world scored major victories for disease control and elimination.
🥳 Maldives became the first country to achieve “triple elimination” of mother-to-child transmission of HIV, syphilis and hepatitis B.
🥳 Burundi, Egypt and Fiji eliminated trachoma.
🥳 Maldives became the first country to achieve “triple elimination” of mother-to-child transmission of HIV, syphilis and hepatitis B.
🥳 Burundi, Egypt and Fiji eliminated trachoma.
Things I dislike:
1. NIH grant reviewers who post major factually false critiques on mentees applications.
2. A distant second is reviewers who cannot compose a grammatically correct sentence. If one does not know how and when to use a comma, one's scientific prowess might be suspect.
1. NIH grant reviewers who post major factually false critiques on mentees applications.
2. A distant second is reviewers who cannot compose a grammatically correct sentence. If one does not know how and when to use a comma, one's scientific prowess might be suspect.
December 22, 2025 at 10:46 PM
Things I dislike:
1. NIH grant reviewers who post major factually false critiques on mentees applications.
2. A distant second is reviewers who cannot compose a grammatically correct sentence. If one does not know how and when to use a comma, one's scientific prowess might be suspect.
1. NIH grant reviewers who post major factually false critiques on mentees applications.
2. A distant second is reviewers who cannot compose a grammatically correct sentence. If one does not know how and when to use a comma, one's scientific prowess might be suspect.
Reposted by Dr. David Boulware, MD MPH
HPV vaccines prevent precancerous lesions in vulva and vagina, study finds
@LizSzabo
For those vaccinated against HPV before age 17, their rate of vaginal or vulvar precancers was 57% lower than for unvaccinated women
www.cidrap.umn.edu/h...
@LizSzabo
For those vaccinated against HPV before age 17, their rate of vaginal or vulvar precancers was 57% lower than for unvaccinated women
www.cidrap.umn.edu/h...
December 19, 2025 at 9:25 PM
HPV vaccines prevent precancerous lesions in vulva and vagina, study finds
@LizSzabo
For those vaccinated against HPV before age 17, their rate of vaginal or vulvar precancers was 57% lower than for unvaccinated women
www.cidrap.umn.edu/h...
@LizSzabo
For those vaccinated against HPV before age 17, their rate of vaginal or vulvar precancers was 57% lower than for unvaccinated women
www.cidrap.umn.edu/h...
Reposted by Dr. David Boulware, MD MPH
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis
Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial
No mortality benefit to high dose rifampin in adults with TB meningitis
www.nejm.org/doi/full/10....
Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial
No mortality benefit to high dose rifampin in adults with TB meningitis
www.nejm.org/doi/full/10....
December 18, 2025 at 12:39 AM
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis
Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial
No mortality benefit to high dose rifampin in adults with TB meningitis
www.nejm.org/doi/full/10....
Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial
No mortality benefit to high dose rifampin in adults with TB meningitis
www.nejm.org/doi/full/10....
Reposted by Dr. David Boulware, MD MPH
Tuberculous meningitis is often fatal, and current therapies need to be improved. In the HARVEST phase 3 trial, high-dose rifampin plus standard treatment was assessed. Full trial results: nej.md/49iiDsQ
#MedSky #NeuroSky #IDSky
#MedSky #NeuroSky #IDSky
December 17, 2025 at 11:00 PM
Tuberculous meningitis is often fatal, and current therapies need to be improved. In the HARVEST phase 3 trial, high-dose rifampin plus standard treatment was assessed. Full trial results: nej.md/49iiDsQ
#MedSky #NeuroSky #IDSky
#MedSky #NeuroSky #IDSky
Minnesota DOT Name a Snowplow competition is back for a 6th Annual year.
www.dot.state.mn.us/nameasnowplow
Last year's winners:
- We're Off To See The Blizzard
- Snowtorious B.I.G.
- Plowabunga!
- Anthony Sledwards
- You're Welcome
- Don'tcha Snow
- Sköl Plow
- I Came, I Thaw, I Conquered
www.dot.state.mn.us/nameasnowplow
Last year's winners:
- We're Off To See The Blizzard
- Snowtorious B.I.G.
- Plowabunga!
- Anthony Sledwards
- You're Welcome
- Don'tcha Snow
- Sköl Plow
- I Came, I Thaw, I Conquered
December 9, 2025 at 11:44 PM
Minnesota DOT Name a Snowplow competition is back for a 6th Annual year.
www.dot.state.mn.us/nameasnowplow
Last year's winners:
- We're Off To See The Blizzard
- Snowtorious B.I.G.
- Plowabunga!
- Anthony Sledwards
- You're Welcome
- Don'tcha Snow
- Sköl Plow
- I Came, I Thaw, I Conquered
www.dot.state.mn.us/nameasnowplow
Last year's winners:
- We're Off To See The Blizzard
- Snowtorious B.I.G.
- Plowabunga!
- Anthony Sledwards
- You're Welcome
- Don'tcha Snow
- Sköl Plow
- I Came, I Thaw, I Conquered
Reposted by Dr. David Boulware, MD MPH
As @gregggonsalves.bsky.social said, here is the main winner in the forced departure of Carl Dieffenbach.
November 24, 2025 at 11:59 AM
As @gregggonsalves.bsky.social said, here is the main winner in the forced departure of Carl Dieffenbach.
Reposted by Dr. David Boulware, MD MPH
New "Osterholm Update" podcast episode! @mtosterholm & @cvdall review the latest flu trends and how this year's vaccine compares to circulating strains. Dr. O also discusses H5N1 impact on mammals in Antarctica and answers an ID Query on infant botulism
www.cidrap.umn.edu/a...
www.cidrap.umn.edu/a...
November 20, 2025 at 7:13 PM
New "Osterholm Update" podcast episode! @mtosterholm & @cvdall review the latest flu trends and how this year's vaccine compares to circulating strains. Dr. O also discusses H5N1 impact on mammals in Antarctica and answers an ID Query on infant botulism
www.cidrap.umn.edu/a...
www.cidrap.umn.edu/a...
Why are CLSI breakpoints for Candida so low? 8 mcg/mL is considered "resistant" in Candida yet this is the MIC50 for Cryptococcus species where we just use higher dose fluconazole 800-1200mg/day.
Is the problem that the FDA package insert says the Candida dose is 100 mg or 200mg once daily?
Is the problem that the FDA package insert says the Candida dose is 100 mg or 200mg once daily?
November 20, 2025 at 5:26 PM
Why are CLSI breakpoints for Candida so low? 8 mcg/mL is considered "resistant" in Candida yet this is the MIC50 for Cryptococcus species where we just use higher dose fluconazole 800-1200mg/day.
Is the problem that the FDA package insert says the Candida dose is 100 mg or 200mg once daily?
Is the problem that the FDA package insert says the Candida dose is 100 mg or 200mg once daily?
Reposted by Dr. David Boulware, MD MPH
#idboardreview A Pt w/travel to Mexico a few months prior (drank tap water, ate raw vegetables) noticed a small worm-like object on inner surface of her lower lip. She removed the object with a needle. Dx? #medEd #idmeded #IDsky #parasitology
November 19, 2025 at 11:17 PM
#idboardreview A Pt w/travel to Mexico a few months prior (drank tap water, ate raw vegetables) noticed a small worm-like object on inner surface of her lower lip. She removed the object with a needle. Dx? #medEd #idmeded #IDsky #parasitology
Is a 28 Point Munich Agrement the solution?
Peace in Our Time.
Peace in Our Time.
Following the Russian missile strike on Ternopil, 26 people have been confirmed killed and 22 remain missing. Search and rescue efforts are still underway.
November 20, 2025 at 2:11 PM
Is a 28 Point Munich Agrement the solution?
Peace in Our Time.
Peace in Our Time.
Webinar: Attributes of pathogen genomic data platforms supporting timely and equitable sharing - Pathogen Forum.
24-Nov-2025, 1 pm CET / 7am EST
pathogenforum.org/webinar-attr...
24-Nov-2025, 1 pm CET / 7am EST
pathogenforum.org/webinar-attr...
Webinar: Attributes of pathogen genomic data platforms supporting timely and equitable sharing - Pathogen Forum
This is part of a series organized by WHO/IPSN in collaboration with the Pathogen Genomics Funders Forum.
pathogenforum.org
November 19, 2025 at 1:47 PM
Webinar: Attributes of pathogen genomic data platforms supporting timely and equitable sharing - Pathogen Forum.
24-Nov-2025, 1 pm CET / 7am EST
pathogenforum.org/webinar-attr...
24-Nov-2025, 1 pm CET / 7am EST
pathogenforum.org/webinar-attr...
Great northern lights night in Minnesota
November 12, 2025 at 2:48 AM
Great northern lights night in Minnesota
Should one be flattered when a published manuscript that is clearly AI written hallucinates and creates citations by you that you never wrote? Paper is not very good, omitting from the abstract use of a bad CrAg test which has poor performance.
What should one do? Contact editor? Or author?
What should one do? Contact editor? Or author?
November 9, 2025 at 1:04 PM
Should one be flattered when a published manuscript that is clearly AI written hallucinates and creates citations by you that you never wrote? Paper is not very good, omitting from the abstract use of a bad CrAg test which has poor performance.
What should one do? Contact editor? Or author?
What should one do? Contact editor? Or author?
Reposted by Dr. David Boulware, MD MPH
Career Opportunity! The California Department of Public Health, TB Control Branch is recruiting for an epidemiologist position.
Interested persons may apply via this website: sjobs.brassring.com/TGnewUI/Sear...
#Tuberculosis #TBSKy
Interested persons may apply via this website: sjobs.brassring.com/TGnewUI/Sear...
#Tuberculosis #TBSKy
Job Search Welcome | University of California San Francisco
Search for Internet job openings.
sjobs.brassring.com
October 24, 2025 at 5:23 PM
Career Opportunity! The California Department of Public Health, TB Control Branch is recruiting for an epidemiologist position.
Interested persons may apply via this website: sjobs.brassring.com/TGnewUI/Sear...
#Tuberculosis #TBSKy
Interested persons may apply via this website: sjobs.brassring.com/TGnewUI/Sear...
#Tuberculosis #TBSKy
Is there a fungus amongst us?
Dr. Fungus App for medical mycology on your phone.
Apple iOS Store: apps.apple.com/us/app/dr-fu...
Google Play Store: play.google.com/store/apps/d...
Dr. Fungus App for medical mycology on your phone.
Apple iOS Store: apps.apple.com/us/app/dr-fu...
Google Play Store: play.google.com/store/apps/d...
Dr. Fungus
The Dr. Fungus app serves as a companion to the official Dr. Fungus website, the Mycoses Study Group Education and Research Consortium resource for fungal disease education. This app provides up-to-d...
apps.apple.com
October 22, 2025 at 12:48 AM
Is there a fungus amongst us?
Dr. Fungus App for medical mycology on your phone.
Apple iOS Store: apps.apple.com/us/app/dr-fu...
Google Play Store: play.google.com/store/apps/d...
Dr. Fungus App for medical mycology on your phone.
Apple iOS Store: apps.apple.com/us/app/dr-fu...
Google Play Store: play.google.com/store/apps/d...
Insurance via ACA marketplace is projected to rise by 21% in Minnesota in 2026.
October 16, 2025 at 12:04 AM
Insurance via ACA marketplace is projected to rise by 21% in Minnesota in 2026.
No longer... CDC EIS RIF'ed.
October 11, 2025 at 1:57 AM
No longer... CDC EIS RIF'ed.
Reposted by Dr. David Boulware, MD MPH
Vaccine for typhoid, invasive Salmonella shows promise in phase 1 trial
Researchers say the investigational three-strain vaccine produced a strong immune response and was well-tolerated in its first human trial.
www.cidrap.umn.edu/s...
Researchers say the investigational three-strain vaccine produced a strong immune response and was well-tolerated in its first human trial.
www.cidrap.umn.edu/s...
October 8, 2025 at 8:31 PM
Vaccine for typhoid, invasive Salmonella shows promise in phase 1 trial
Researchers say the investigational three-strain vaccine produced a strong immune response and was well-tolerated in its first human trial.
www.cidrap.umn.edu/s...
Researchers say the investigational three-strain vaccine produced a strong immune response and was well-tolerated in its first human trial.
www.cidrap.umn.edu/s...
Predictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care
Nice paper by U of MN MD/PhD student Eli Schwartz on behalf of the ENCORE Team.
track.smtpsendmail.com/9032119/c?p=...
Nice paper by U of MN MD/PhD student Eli Schwartz on behalf of the ENCORE Team.
track.smtpsendmail.com/9032119/c?p=...
Predictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care
Among Ugandan outpatients with advanced HIV, elevated serum CRP (≥10 mg/L) predicted 30-day risk of opportunistic infection, hospitalization, and death. Ea
track.smtpsendmail.com
October 8, 2025 at 5:54 PM
Predictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care
Nice paper by U of MN MD/PhD student Eli Schwartz on behalf of the ENCORE Team.
track.smtpsendmail.com/9032119/c?p=...
Nice paper by U of MN MD/PhD student Eli Schwartz on behalf of the ENCORE Team.
track.smtpsendmail.com/9032119/c?p=...
Twin Cities Marathon Day.
Brunch with neighbors on front lawn cheering on runners.
Brunch with neighbors on front lawn cheering on runners.
October 5, 2025 at 2:51 PM
Twin Cities Marathon Day.
Brunch with neighbors on front lawn cheering on runners.
Brunch with neighbors on front lawn cheering on runners.
Excited to speak at UT Houston-Methodist on Friday on "Innovative Clinical Trial Designs in ID"
First time I have been back to Houston in 26 years. It's still hot... and even more buildings on medical campus.
First time I have been back to Houston in 26 years. It's still hot... and even more buildings on medical campus.
October 2, 2025 at 8:16 PM
Excited to speak at UT Houston-Methodist on Friday on "Innovative Clinical Trial Designs in ID"
First time I have been back to Houston in 26 years. It's still hot... and even more buildings on medical campus.
First time I have been back to Houston in 26 years. It's still hot... and even more buildings on medical campus.
Mycosis Study Group has released DrFungus app for phones as a reference companion for yeast and mold infections.
iPhone apps.apple.com/us/app/dr-fu...
Android play.google.com/store/apps/d...
App designed by Dr Matt Pullen. @msgerc.bsky.social
iPhone apps.apple.com/us/app/dr-fu...
Android play.google.com/store/apps/d...
App designed by Dr Matt Pullen. @msgerc.bsky.social
Dr. Fungus
The Dr. Fungus app serves as a companion to the official Dr. Fungus website, the Mycoses Study Group Education and Research Consortium resource for fungal disease education. This app provides up-to-d...
apps.apple.com
September 18, 2025 at 5:54 AM
Mycosis Study Group has released DrFungus app for phones as a reference companion for yeast and mold infections.
iPhone apps.apple.com/us/app/dr-fu...
Android play.google.com/store/apps/d...
App designed by Dr Matt Pullen. @msgerc.bsky.social
iPhone apps.apple.com/us/app/dr-fu...
Android play.google.com/store/apps/d...
App designed by Dr Matt Pullen. @msgerc.bsky.social
Reposted by Dr. David Boulware, MD MPH
More Than 20 Medical Groups Call For RFK Jr. To Resign
#IDSky #MedSky
www.idsociety.org/news--public...
#IDSky #MedSky
www.idsociety.org/news--public...
Joint statement calling for Secretary Kennedy resignation
www.idsociety.org
September 5, 2025 at 12:10 PM
More Than 20 Medical Groups Call For RFK Jr. To Resign
#IDSky #MedSky
www.idsociety.org/news--public...
#IDSky #MedSky
www.idsociety.org/news--public...
Reposted by Dr. David Boulware, MD MPH
Two studies, same signal👇
📊 COVID-OUT RCT: 41% ↓ long COVID with 14d metformin (1500 mg/day by Day 6).
📊 CID UK cohort (766k pts): 64% ↓ long COVID if metformin started within 90d.
Cheap, safe, generic drug. Replication across RCT + real world = 🔥
#MedSky
📊 COVID-OUT RCT: 41% ↓ long COVID with 14d metformin (1500 mg/day by Day 6).
📊 CID UK cohort (766k pts): 64% ↓ long COVID if metformin started within 90d.
Cheap, safe, generic drug. Replication across RCT + real world = 🔥
#MedSky
Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese: A Population-based Retrospective Cohort Study
Early metformin treatment in overweight or obese adults with recent coronavirus disease 2019 infection significantly reduces the risk of developing post–co
academic.oup.com
September 3, 2025 at 7:50 PM
Two studies, same signal👇
📊 COVID-OUT RCT: 41% ↓ long COVID with 14d metformin (1500 mg/day by Day 6).
📊 CID UK cohort (766k pts): 64% ↓ long COVID if metformin started within 90d.
Cheap, safe, generic drug. Replication across RCT + real world = 🔥
#MedSky
📊 COVID-OUT RCT: 41% ↓ long COVID with 14d metformin (1500 mg/day by Day 6).
📊 CID UK cohort (766k pts): 64% ↓ long COVID if metformin started within 90d.
Cheap, safe, generic drug. Replication across RCT + real world = 🔥
#MedSky