@denklab
@denklab.bsky.social
My team and I study why pain can become chronic. We like the peripheral nervous system, neuroimmunology, stromal cells and sequencing. If you have similar interests - please say hi!
Reposted by @denklab
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
November 12, 2025 at 6:19 PM
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Reposted by @denklab
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
www.biorxiv.org
November 1, 2025 at 12:10 PM
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
Reposted by @denklab
A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...
GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception
Localised acidification from immune cell infiltration and heightened glycolysis contributes
to colitis pathology by activating acid-sensing receptors such as GPR68, a proton-sensing
GPCR expressed on ...
www.cmghjournal.org
November 4, 2025 at 4:49 PM
A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...
Reposted by @denklab
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Reposted by @denklab
🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease.
🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/
#NaV #ionchannels #cardiacphysiology #scienceconference
🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/
#NaV #ionchannels #cardiacphysiology #scienceconference
October 30, 2025 at 8:50 AM
🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease.
🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/
#NaV #ionchannels #cardiacphysiology #scienceconference
🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/
#NaV #ionchannels #cardiacphysiology #scienceconference
Reposted by @denklab
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by @denklab
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...
doi.org
October 27, 2025 at 4:54 PM
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Reposted by @denklab
Prof Selina Wray will join us as our careers keynote, sharing her journey from a working class background and part time work through to a professorship, and Dr Carole Torsney, our research keynote, will tell us about her preclinical research on sex & gender disparities in pain.
October 12, 2025 at 7:05 PM
Prof Selina Wray will join us as our careers keynote, sharing her journey from a working class background and part time work through to a professorship, and Dr Carole Torsney, our research keynote, will tell us about her preclinical research on sex & gender disparities in pain.
Reposted by @denklab
Coming soon thanks to @ish1789.bsky.social sparc.science/datasets/480. Lots and lots of data!
SPARC Portal
The open community platform for bridging the body and the brain through neuroscience and systems physiology data, computational and spatial modeling, and device design.
sparc.science
October 8, 2025 at 10:39 PM
Coming soon thanks to @ish1789.bsky.social sparc.science/datasets/480. Lots and lots of data!
Reposted by @denklab
Stuart Bevan and I are offering an exciting MRC DTP-funded PhD project exploring the mechanisms of pain in Long COVID.
Find out more about the project here:
🔗 tinyurl.com/3caseacv
Application deadline: 28th October
@wolfsonsparc.bsky.social y.social
@kingsioppn.bsky.social sioppn.bsky.social
Find out more about the project here:
🔗 tinyurl.com/3caseacv
Application deadline: 28th October
@wolfsonsparc.bsky.social y.social
@kingsioppn.bsky.social sioppn.bsky.social
October 6, 2025 at 9:09 AM
Stuart Bevan and I are offering an exciting MRC DTP-funded PhD project exploring the mechanisms of pain in Long COVID.
Find out more about the project here:
🔗 tinyurl.com/3caseacv
Application deadline: 28th October
@wolfsonsparc.bsky.social y.social
@kingsioppn.bsky.social sioppn.bsky.social
Find out more about the project here:
🔗 tinyurl.com/3caseacv
Application deadline: 28th October
@wolfsonsparc.bsky.social y.social
@kingsioppn.bsky.social sioppn.bsky.social
Reposted by @denklab
New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1
October 4, 2025 at 8:34 AM
New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1
Reposted by @denklab
Great to have this out: wonderful team effort, & nice to build on work from others that had identified the dysregulated osteoarthritis lipidome 😃 #neuroskyence #PainResearch
#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
October 2, 2025 at 6:18 PM
Great to have this out: wonderful team effort, & nice to build on work from others that had identified the dysregulated osteoarthritis lipidome 😃 #neuroskyence #PainResearch
Reposted by @denklab
📊 Want to boost your research skills?
Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10).
✅ Free to attend
🙋♀️ Open to all career stages
🚆 Travel and accommodation costs reimbursed
Apply by October 17th 👉 www.giba-uk.org/training-opp...
Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10).
✅ Free to attend
🙋♀️ Open to all career stages
🚆 Travel and accommodation costs reimbursed
Apply by October 17th 👉 www.giba-uk.org/training-opp...
October 1, 2025 at 8:38 AM
📊 Want to boost your research skills?
Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10).
✅ Free to attend
🙋♀️ Open to all career stages
🚆 Travel and accommodation costs reimbursed
Apply by October 17th 👉 www.giba-uk.org/training-opp...
Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10).
✅ Free to attend
🙋♀️ Open to all career stages
🚆 Travel and accommodation costs reimbursed
Apply by October 17th 👉 www.giba-uk.org/training-opp...
Reposted by @denklab
We are proud to launch what we think is going to be fantastic opportunity for pain neuroscientists and clinicians to learn the foundations of pain neuroscience
September is #PainAwarenessMonth, and we are excited to be launching our brand-new MSc in Pain Neurosciences. Could you help shape the future of #pain research? Opening soon for 2026 admissions 👀
Learn more 👇
bit.ly/OxMScPain
Learn more 👇
bit.ly/OxMScPain
October 1, 2025 at 5:55 AM
We are proud to launch what we think is going to be fantastic opportunity for pain neuroscientists and clinicians to learn the foundations of pain neuroscience
Reposted by @denklab
Our NEW working groups support effective collaborations across the UK.
Could you help answer one of our first 5️⃣ key research questions?
👉 www.giba-uk.org/working-groups
🙋♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.
Could you help answer one of our first 5️⃣ key research questions?
👉 www.giba-uk.org/working-groups
🙋♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.
September 29, 2025 at 12:32 PM
Our NEW working groups support effective collaborations across the UK.
Could you help answer one of our first 5️⃣ key research questions?
👉 www.giba-uk.org/working-groups
🙋♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.
Could you help answer one of our first 5️⃣ key research questions?
👉 www.giba-uk.org/working-groups
🙋♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.
Reposted by @denklab
Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch
Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets https://www.biorxiv.org/content/10.1101/2025.09.20.677124v1
September 22, 2025 at 2:54 PM
Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch
If you are UK-based and interested in Gut-Immune-Brain Axis research, do sign up to our GIBA+ network and its working groups! You will get access to lots of new contacts, publication and funding opportunities 🧪🧠🤑 #PainResearch #PainScience #neuroskyence #ImmunoSky
Our working groups support the development of effective collaborations across the UK to advance research.
Introduced by Franziska Denk (@denklab.bsky.social) at our #GIBANetworklaunch.
Want to know our first 5️⃣ topics? Find out here 👇
www.giba-uk.org/working-groups
Introduced by Franziska Denk (@denklab.bsky.social) at our #GIBANetworklaunch.
Want to know our first 5️⃣ topics? Find out here 👇
www.giba-uk.org/working-groups
September 22, 2025 at 2:53 PM
If you are UK-based and interested in Gut-Immune-Brain Axis research, do sign up to our GIBA+ network and its working groups! You will get access to lots of new contacts, publication and funding opportunities 🧪🧠🤑 #PainResearch #PainScience #neuroskyence #ImmunoSky
Reposted by @denklab
The past two decades have seen a global explosion of research into the gut-immune-brain axis.
There is great energy in #Southampton today for our #GIBANetworklaunch.
Together, we are building a vibrant and diverse research community to fully realise GIBA's potential.
Learn more 👉 www.giba-uk.org
There is great energy in #Southampton today for our #GIBANetworklaunch.
Together, we are building a vibrant and diverse research community to fully realise GIBA's potential.
Learn more 👉 www.giba-uk.org
September 22, 2025 at 9:42 AM
The past two decades have seen a global explosion of research into the gut-immune-brain axis.
There is great energy in #Southampton today for our #GIBANetworklaunch.
Together, we are building a vibrant and diverse research community to fully realise GIBA's potential.
Learn more 👉 www.giba-uk.org
There is great energy in #Southampton today for our #GIBANetworklaunch.
Together, we are building a vibrant and diverse research community to fully realise GIBA's potential.
Learn more 👉 www.giba-uk.org
Reposted by @denklab
New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub
September 13, 2025 at 3:32 PM
New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub
Reposted by @denklab
Thanks to everyone who made #NeuPSIG2025 so great, and to the photographer here who somehow managed to capture everyone (?) at this table
September 8, 2025 at 3:29 PM
Thanks to everyone who made #NeuPSIG2025 so great, and to the photographer here who somehow managed to capture everyone (?) at this table
Reposted by @denklab
Fancy a #neuroskyence trip to Alicante in December?
You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...
You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...
Christmas Meeting - Instituto de Neurociencias de Alicante
Este tradicional encuentro, que se realiza en el mes de diciembre de cada año, tiene como finalidad la interacción de investigadores que actualmente trabajan en instituciones de prestigio internaciona...
in.umh-csic.es
September 5, 2025 at 4:52 PM
Fancy a #neuroskyence trip to Alicante in December?
You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...
You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...
Reposted by @denklab
On my way home after an excellent trip. First, I went to Poland to visit @mwklab.bsky.social and give a talk together with @gg9761.bsky.social and Jimena Perez-Sanchez. Next, we all went to Berlin 🚂 to participate in #NeuPSIG where I got to hang out with more of my favorite scientists! #PainResearch
September 7, 2025 at 2:03 PM
On my way home after an excellent trip. First, I went to Poland to visit @mwklab.bsky.social and give a talk together with @gg9761.bsky.social and Jimena Perez-Sanchez. Next, we all went to Berlin 🚂 to participate in #NeuPSIG where I got to hang out with more of my favorite scientists! #PainResearch
Reposted by @denklab
Quick reminder as we head into #NeuPSIG that we have a #PainResearch feed and conferences are the best time to force your friends to join bsky
bsky.app/profile/did:...
bsky.app/profile/did:...
September 3, 2025 at 9:41 AM
Quick reminder as we head into #NeuPSIG that we have a #PainResearch feed and conferences are the best time to force your friends to join bsky
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by @denklab
What better way to get excited for #NeuPSIG2025 than a @utdpaincenter.bsky.social test run of our Machine Learning Workshop? #PainResearch
August 28, 2025 at 6:09 PM
What better way to get excited for #NeuPSIG2025 than a @utdpaincenter.bsky.social test run of our Machine Learning Workshop? #PainResearch
Reposted by @denklab
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.
Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...
August 24, 2025 at 3:21 PM
BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.