Jiri Hofbrucker
@deepjdog.bsky.social
Empowering neuroscientists with fiber-based microscopic systems for imaging at any brain depth
CTO at DeepEn, @deepen-imaging.bsky.social
( https://deepen-imaging.com/ )
CTO at DeepEn, @deepen-imaging.bsky.social
( https://deepen-imaging.com/ )
Pinned
Jiri Hofbrucker
@deepjdog.bsky.social
· Dec 3
Hi all! I’m developing a fiber endoscope that uses a 100-micron fiber to perform fluorescence imaging deep in tissues. I’m especially keen to connect with neuroscientists and anyone passionate about fluorescence imaging. Let’s share ideas and collaborate! #firstskeet #neuroscience #calciumimaging
I'm excited to join #SfN2025 next week. Stop by booth #3027 to connect and learn more about structural and functional imaging in-vivo anywhere in the brain! I’d love to hear about your research and ideas! Looking forward to meeting you there.
November 7, 2025 at 7:36 AM
I'm excited to join #SfN2025 next week. Stop by booth #3027 to connect and learn more about structural and functional imaging in-vivo anywhere in the brain! I’d love to hear about your research and ideas! Looking forward to meeting you there.
Reposted by Jiri Hofbrucker
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
![Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: “Cyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, “Engineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:in2pnzujy66a7qnesoxha6ar/bafkreig4udiootxzzdxay4vwclppbwedfythnr36dzzoavgbrzvz2m54va@jpeg)
November 3, 2025 at 7:28 PM
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠What do neuroscientists think of DeepEn's holographic microendoscope?
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?
⭐ Check the Nature’s article:
www.nature.com/articles/d42...
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?
⭐ Check the Nature’s article:
www.nature.com/articles/d42...
High-resolution insights from the deep brain
Discover the world’s best science and medicine | Nature.com
www.nature.com
October 7, 2025 at 11:53 AM
🧠What do neuroscientists think of DeepEn's holographic microendoscope?
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?
⭐ Check the Nature’s article:
www.nature.com/articles/d42...
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?
⭐ Check the Nature’s article:
www.nature.com/articles/d42...
Reposted by Jiri Hofbrucker
Excited to share we’ve been awarded the ERC StG 🎉 for our project ProSocial, studying neural mechanisms of prosocial behavior in health & disease. Huge thanks to my group for their amazing work & to great colleagues for their support! Positions opening soon—reach out if interested!
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 2:20 PM
Excited to share we’ve been awarded the ERC StG 🎉 for our project ProSocial, studying neural mechanisms of prosocial behavior in health & disease. Huge thanks to my group for their amazing work & to great colleagues for their support! Positions opening soon—reach out if interested!
Are you the kind of neuroscientist who scripts analysis or can’t resist tinkering with hardware?
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...
DeepEn hiring Neuroscience Imaging Scientist (Microscopy + Applications) in Jena, Thuringia, Germany | LinkedIn
Posted 8:01:32 PM. DeepEn develops minimally invasive microendoscopes for neuroscience applications. We transform a…See this and similar jobs on LinkedIn.
www.linkedin.com
September 2, 2025 at 6:12 AM
Are you the kind of neuroscientist who scripts analysis or can’t resist tinkering with hardware?
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...
Reposted by Jiri Hofbrucker
⏰ Reminder: The early bird registration and abstract submission for our 5th Day of Intravital Microscopy close on September 5!
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ
5th Day of Intravital Microscopy - German BioImaging
Intravital microscopy (IVM) enables the observation and precise quantification of cellular processes within native tissue microenvironments, with resolutions unmatched by other techniques. This powerf...
bit.ly
September 1, 2025 at 8:25 AM
⏰ Reminder: The early bird registration and abstract submission for our 5th Day of Intravital Microscopy close on September 5!
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ
Reposted by Jiri Hofbrucker
Beautiful work!
September 1, 2025 at 9:22 AM
Beautiful work!
Reposted by Jiri Hofbrucker
Fun collaborative work together with the amazing lab of @sophiesteculorum.bsky.social now published!
📢 🤩Excited to share our latest paper👃🧠! Huge thanks to the amazing first author @janice-bulk.bsky.social and all co-authors, especially @andreas-t-schaefer.bsky.social and @tobiasackels.bsky.social 🙌!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
www.nature.com
June 11, 2025 at 2:36 PM
Fun collaborative work together with the amazing lab of @sophiesteculorum.bsky.social now published!
Reposted by Jiri Hofbrucker
Reposted by Jiri Hofbrucker
Hippocampal vasculature is so pretty 😍
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy
May 14, 2025 at 9:25 PM
Hippocampal vasculature is so pretty 😍
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy
Reposted by Jiri Hofbrucker
Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo
Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged
Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity
and altered tuning of fa...
www.cell.com
May 8, 2025 at 7:51 PM
Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Jiri Hofbrucker
Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!
January 20, 2025 at 10:22 AM
Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!
Reposted by Jiri Hofbrucker
Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)
TH staining in cyan
Virus injection in magenta
Zona Incerta is definitely a tough cookie 🍪 but getting there!
#fluorescenceFriday (but a day earlier)
TH staining in cyan
Virus injection in magenta
Zona Incerta is definitely a tough cookie 🍪 but getting there!
May 1, 2025 at 6:58 PM
Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)
TH staining in cyan
Virus injection in magenta
Zona Incerta is definitely a tough cookie 🍪 but getting there!
#fluorescenceFriday (but a day earlier)
TH staining in cyan
Virus injection in magenta
Zona Incerta is definitely a tough cookie 🍪 but getting there!
Reposted by Jiri Hofbrucker
🧠 GABA! 🔬✨Explore groundbreaking research on the GABAergic system and its role in health and disease in humans and rodents.
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute
March 30, 2025 at 7:31 PM
🧠 GABA! 🔬✨Explore groundbreaking research on the GABAergic system and its role in health and disease in humans and rodents.
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute
Reposted by Jiri Hofbrucker
Excellent Norbert Elsner Lecture by Rui Costa @ruimcosta.bsky.social, Göttingen Meeting of @neurowissg.bsky.social
March 28, 2025 at 8:30 AM
Excellent Norbert Elsner Lecture by Rui Costa @ruimcosta.bsky.social, Göttingen Meeting of @neurowissg.bsky.social
Reposted by Jiri Hofbrucker
📣 1 week to go!
Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬
📍at the 16th Göttingen Meeting of the German Neuroscience Society
Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience
Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬
📍at the 16th Göttingen Meeting of the German Neuroscience Society
Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience
March 20, 2025 at 12:31 PM
📣 1 week to go!
Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬
📍at the 16th Göttingen Meeting of the German Neuroscience Society
Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience
Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬
📍at the 16th Göttingen Meeting of the German Neuroscience Society
Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience
Reposted by Jiri Hofbrucker
Just so happened to see this beauty today while recording in Kash Lab @superkash.bsky.social. Happy #FluorescenceFriday 🤩🔬
March 14, 2025 at 10:18 PM
Just so happened to see this beauty today while recording in Kash Lab @superkash.bsky.social. Happy #FluorescenceFriday 🤩🔬
Reposted by Jiri Hofbrucker
Happy #BrainAwarenessWeek! Join this international celebration of the brain with this visual exploration of its makeup and neighborhoods: alleninstitute.org/news/what-ar...
🧠📈 @danafoundation.bsky.social
🧠📈 @danafoundation.bsky.social
March 13, 2025 at 6:48 PM
Happy #BrainAwarenessWeek! Join this international celebration of the brain with this visual exploration of its makeup and neighborhoods: alleninstitute.org/news/what-ar...
🧠📈 @danafoundation.bsky.social
🧠📈 @danafoundation.bsky.social
Reposted by Jiri Hofbrucker
Do you want to join a great team and work on cutting-edge confocal microscopy systems?
Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!
Apply here: confocal.recruitee.com/o/product-ap...
Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!
Apply here: confocal.recruitee.com/o/product-ap...
March 10, 2025 at 12:43 PM
Do you want to join a great team and work on cutting-edge confocal microscopy systems?
Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!
Apply here: confocal.recruitee.com/o/product-ap...
Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!
Apply here: confocal.recruitee.com/o/product-ap...
Reposted by Jiri Hofbrucker
The MAC lab is hiring a full-time lab manager to start in June! You will have the opportunity to conduct research projects relating to long-term memory and concept knowledge (methods include online and in-person behavioral experiments, fMRI, TMS). Apply by March 26 careers.drexel.edu/cw/en-us/job...
MAC lab
How does our prior knowledge impact how we learn new information? How do memories change over time? We use cognitive neuroscience methods to understand how the brain stores, organizes, and transforms ...
www.memoryandconceptslab.org
March 10, 2025 at 8:55 PM
The MAC lab is hiring a full-time lab manager to start in June! You will have the opportunity to conduct research projects relating to long-term memory and concept knowledge (methods include online and in-person behavioral experiments, fMRI, TMS). Apply by March 26 careers.drexel.edu/cw/en-us/job...
Reposted by Jiri Hofbrucker
As part of #NEUROGATE, the Haesler lab is helping develop a holographic endoscope for high-resolution, deep-brain imaging. Supported by a €2.5M EIC grant, this ultra-thin fiber technology could transform neuroscience & neurotech.
nerf.be/en/news#/new...
nerf.be/en/news#/new...
February 11, 2025 at 10:22 AM
As part of #NEUROGATE, the Haesler lab is helping develop a holographic endoscope for high-resolution, deep-brain imaging. Supported by a €2.5M EIC grant, this ultra-thin fiber technology could transform neuroscience & neurotech.
nerf.be/en/news#/new...
nerf.be/en/news#/new...
Reposted by Jiri Hofbrucker
The research team from @leibnizipht.bsky.social, DeepEn, the Institute of Scientific Instruments @czechacademy.bsky.social & @nerflabs.bsky.social is developing this innovative imaging technology to visualize neuronal processes in living organisms with high precision.
February 3, 2025 at 1:08 PM
The research team from @leibnizipht.bsky.social, DeepEn, the Institute of Scientific Instruments @czechacademy.bsky.social & @nerflabs.bsky.social is developing this innovative imaging technology to visualize neuronal processes in living organisms with high precision.
Reposted by Jiri Hofbrucker
Dr. Jörg Philipps erhält den Robert Wartenberg-Preis 2025 für seine Arbeiten zu diagnostischen Anwendungen des hochauflösenden Nervenultraschalls in der #Neurologie. Herzlichen Glückwunsch! 👉 dgn.org/artikel/robe... #neuroskyence
Foto:© DGN/Claudius Pflug
Foto:© DGN/Claudius Pflug
March 7, 2025 at 10:27 AM
Dr. Jörg Philipps erhält den Robert Wartenberg-Preis 2025 für seine Arbeiten zu diagnostischen Anwendungen des hochauflösenden Nervenultraschalls in der #Neurologie. Herzlichen Glückwunsch! 👉 dgn.org/artikel/robe... #neuroskyence
Foto:© DGN/Claudius Pflug
Foto:© DGN/Claudius Pflug
Reposted by Jiri Hofbrucker
Happy to provide a #TIM2025 Workshop and present together with Dr. Peter Hemmerich, from the CF Imaging of the Leibniz Institute on Aging – FLI, image Quality Control, restoration, deconvolution, denoising, and analysis of confocal and STED data. #microscopy #science
March 6, 2025 at 11:30 AM
Happy to provide a #TIM2025 Workshop and present together with Dr. Peter Hemmerich, from the CF Imaging of the Leibniz Institute on Aging – FLI, image Quality Control, restoration, deconvolution, denoising, and analysis of confocal and STED data. #microscopy #science
Excited to attend the 16th Göttingen Meeting of the @neurowissg.bsky.social in three weeks! Looking forward to insightful discussions and cutting-edge research. If you're attending, let’s connect—I’d love to catch up in person!
See you in Göttingen! 🚀🔬 #Neuroscience #GöttingenMeeting #NWG2025
See you in Göttingen! 🚀🔬 #Neuroscience #GöttingenMeeting #NWG2025
March 6, 2025 at 11:45 AM
Excited to attend the 16th Göttingen Meeting of the @neurowissg.bsky.social in three weeks! Looking forward to insightful discussions and cutting-edge research. If you're attending, let’s connect—I’d love to catch up in person!
See you in Göttingen! 🚀🔬 #Neuroscience #GöttingenMeeting #NWG2025
See you in Göttingen! 🚀🔬 #Neuroscience #GöttingenMeeting #NWG2025