Bisrat Debeb
@debeblab.bsky.social
Associate Professor at MD Anderson Cancer Center- investigating the biology of brain metastasis in aggressive breast cancers, Inflammatory breast cancer (IBC), TNBC. Posts are my own.
Pinned
Bisrat Debeb
@debeblab.bsky.social
· Jun 27
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2
👉 biorxiv.org/content/10.110…
👉 biorxiv.org/content/10.110…
Reposted by Bisrat Debeb
Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social
August 4, 2025 at 4:15 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social
Reposted by Bisrat Debeb
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
July 30, 2025 at 4:15 PM
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Reposted by Bisrat Debeb
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
July 30, 2025 at 3:38 AM
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Reposted by Bisrat Debeb
New Science story about multi-year funding and it potential catastrophic consequences
www.science.org/content/arti...
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Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
www.science.org
July 29, 2025 at 1:44 AM
New Science story about multi-year funding and it potential catastrophic consequences
www.science.org/content/arti...
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www.science.org/content/arti...
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Reposted by Bisrat Debeb
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker
Penny Pritzker Warns Trump Cuts Threaten US in Global Tech Race
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said Penny Pritzker, former US commerce secretary and chair of Harvard University’s powerful governing body.
bloom.bg
July 24, 2025 at 8:30 PM
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker
Reposted by Bisrat Debeb
In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.
July 24, 2025 at 12:15 AM
In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.
Reposted by Bisrat Debeb
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
July 23, 2025 at 7:35 PM
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
Reposted by Bisrat Debeb
“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.”
Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
Fay: Cuts to research funding risk the collapse of U.S. science and technology
I started as an assistant professor of molecular biology at the University of Wyoming in 2001.
www.wyomingnews.com
July 20, 2025 at 6:11 PM
“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.”
Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...
Funding scientific research is the only way we will cure cancer • Pennsylvania Capital-Star
The proposed federal budget for next year includes a 55% cut to the National Science Foundation (NSF) and a 44% cut to National Institutes of Health (NIH).
penncapital-star.com
July 16, 2025 at 3:01 AM
Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...
Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...
Pan-cancer human brain metastases atlas at single-cell resolution
Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas
at single-cell resolution, uncovering five major BrM ecotypes associated with distinct
phenotypic characteristics. T...
www.cell.com
July 14, 2025 at 11:36 PM
Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...
Reposted by Bisrat Debeb
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
July 10, 2025 at 12:23 AM
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Reposted by Bisrat Debeb
Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later.
Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer
Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer
Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.
spr.ly
July 10, 2025 at 8:21 PM
Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later.
Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer
Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer
Reposted by Bisrat Debeb
After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️
@dalimartinez.bsky.social 🧪
@dalimartinez.bsky.social 🧪
July 3, 2025 at 9:52 PM
After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️
@dalimartinez.bsky.social 🧪
@dalimartinez.bsky.social 🧪
Reposted by Bisrat Debeb
Important research on IBC that can also benefit understanding other types of aggressive #breastcancer
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2
👉 biorxiv.org/content/10.110…
👉 biorxiv.org/content/10.110…
June 29, 2025 at 6:56 AM
Important research on IBC that can also benefit understanding other types of aggressive #breastcancer
Reposted by Bisrat Debeb
Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky
🧠 Neuro-immunology is reshaping how we understand the brain - across many diseases, including #cancer
In this research highlight 🧪🔬 we discuss a new study in #Nature by Remsik, Boire et al showing how IFNγ-activated immune cells in the CNS, incl DCs, help constrain leptomeningeal #metastasis
In this research highlight 🧪🔬 we discuss a new study in #Nature by Remsik, Boire et al showing how IFNγ-activated immune cells in the CNS, incl DCs, help constrain leptomeningeal #metastasis
CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis - Cell Research
Cell Research - CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis
www.nature.com
June 27, 2025 at 2:53 PM
Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky
Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2
👉 biorxiv.org/content/10.110…
👉 biorxiv.org/content/10.110…
June 27, 2025 at 12:36 AM
Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2
👉 biorxiv.org/content/10.110…
👉 biorxiv.org/content/10.110…
June 27, 2025 at 12:30 AM
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2
👉 biorxiv.org/content/10.110…
👉 biorxiv.org/content/10.110…
Reposted by Bisrat Debeb
Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.
Vanderbilt University Medical Center to lay off up to 650 after Trump administration grant cuts • Tennessee Lookout
Vanderbilt University Medical Center, expects to lay off 650 employees as a result of grant and funding cuts by the Trump Administration,
tennesseelookout.com
June 20, 2025 at 8:00 PM
Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.
Reposted by Bisrat Debeb
The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth.
Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
Trump’s Cuts to Science Funding Could Hurt U.S. Economy, Study Shows
Reducing federal support for research and development could cause long-run economic damage and reduce government revenue.
www.nytimes.com
May 1, 2025 at 7:50 PM
The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth.
Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
Reposted by Bisrat Debeb
The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants.
www.spencer.org/grant_types/...
www.spencer.org/grant_types/...
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
www.spencer.org
May 2, 2025 at 9:07 PM
The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants.
www.spencer.org/grant_types/...
www.spencer.org/grant_types/...
Reposted by Bisrat Debeb
FYI “Spencer Foundation, Alfred P. Sloan Foundation, William T. Grant Foundation and Kapor Foundation are providing quick turnaround grants of up to $25k for education scholars impacted by the abrupt NSF grant cancellations.” www.spencer.org/news/meeting...
Meeting the Moment Together
We are returning from the AERA Annual Meeting in Denver reinvigorated and with a deep appreciation for all that scholars and higher education leaders are holding in this moment. Rapid shifts in fed...
www.spencer.org
May 2, 2025 at 11:10 PM
FYI “Spencer Foundation, Alfred P. Sloan Foundation, William T. Grant Foundation and Kapor Foundation are providing quick turnaround grants of up to $25k for education scholars impacted by the abrupt NSF grant cancellations.” www.spencer.org/news/meeting...
Reposted by Bisrat Debeb
Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.
April 20, 2025 at 10:29 PM
Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.
Congratulations Drs Woodward and Lynce on developing a new #IBC scoring system to improve IBC diagnosis. #IBCdiagnosis
Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...
Development of a Multi-Institutional Dataset to Validate a Novel Inflammatory Breast Cancer Diagnostic Score
AbstractPurpose. Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinician
academic.oup.com
April 2, 2025 at 3:38 AM
Congratulations Drs Woodward and Lynce on developing a new #IBC scoring system to improve IBC diagnosis. #IBCdiagnosis
Reposted by Bisrat Debeb
Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...
Development of a Multi-Institutional Dataset to Validate a Novel Inflammatory Breast Cancer Diagnostic Score
AbstractPurpose. Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinician
academic.oup.com
April 2, 2025 at 1:44 AM
Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...
Reposted by Bisrat Debeb
A huge loss at FDA.
Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...
Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...
Exclusive | Top Vaccine Official Out at FDA
In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.
www.wsj.com
March 29, 2025 at 1:23 AM
A huge loss at FDA.
Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...
Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...