Damir Vareslija
@damirvareslija.bsky.social
Cancer Researcher based in RCSI University of Medicine and Health Sciences, Ireland | “doing” research on cancer metastasis, focusing on metastatic breast cancer and brain metastases.
Great way to finish the GRC Hormone-Dependent Cancers Conference by seeing our collaboration with the Wilbert Zwart lab published in PNAS. Glad to have contributed to this work.
Read the paper here: www.pnas.org/doi/10.1073/...
Read the paper here: www.pnas.org/doi/10.1073/...
August 15, 2025 at 9:29 PM
Great way to finish the GRC Hormone-Dependent Cancers Conference by seeing our collaboration with the Wilbert Zwart lab published in PNAS. Glad to have contributed to this work.
Read the paper here: www.pnas.org/doi/10.1073/...
Read the paper here: www.pnas.org/doi/10.1073/...
Our review in Cancer Letters is live! 🧠🔬
“Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment” proposes potential links between sex hormones and neural niche adaptation in brain mets.
www.sciencedirect.com/science/arti...
#BrainMetastasis #CancerResearch #NeuroOncology
“Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment” proposes potential links between sex hormones and neural niche adaptation in brain mets.
www.sciencedirect.com/science/arti...
#BrainMetastasis #CancerResearch #NeuroOncology
Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment
Metastatic progression drives the majority of cancer-related fatalities, and involvement of the central nervous system (CNS) poses especially formidab…
www.sciencedirect.com
April 30, 2025 at 4:11 PM
Our review in Cancer Letters is live! 🧠🔬
“Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment” proposes potential links between sex hormones and neural niche adaptation in brain mets.
www.sciencedirect.com/science/arti...
#BrainMetastasis #CancerResearch #NeuroOncology
“Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment” proposes potential links between sex hormones and neural niche adaptation in brain mets.
www.sciencedirect.com/science/arti...
#BrainMetastasis #CancerResearch #NeuroOncology
Reposted by Damir Vareslija
Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...
www.cell.com/trends/cance...
Regulation of metastatic organotropism
Metastasis is responsible for most cancer-related deaths. Different cancers have their
own preferential sites of metastases, a phenomenon termed metastatic organotropism.
The mechanisms underlying org...
www.cell.com
March 29, 2025 at 6:16 AM
Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...
www.cell.com/trends/cance...
Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring: www.nature.com/articles/s41...
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
The epigenetic landscape of brain metastasis - Oncogene
Oncogene - The epigenetic landscape of brain metastasis
www.nature.com
February 27, 2025 at 4:37 PM
Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring: www.nature.com/articles/s41...
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
Reposted by Damir Vareslija
📢 Last chance to register for the
IACR conference, featuring leading experts in AI, drug development, obesity & nutrition, stem cells, and cancer plasticity. Don’t miss out!
Stay tuned as we spotlight our fantastic speaker lineup leading up to the conference.
IACR conference, featuring leading experts in AI, drug development, obesity & nutrition, stem cells, and cancer plasticity. Don’t miss out!
Stay tuned as we spotlight our fantastic speaker lineup leading up to the conference.
January 23, 2025 at 7:09 AM
📢 Last chance to register for the
IACR conference, featuring leading experts in AI, drug development, obesity & nutrition, stem cells, and cancer plasticity. Don’t miss out!
Stay tuned as we spotlight our fantastic speaker lineup leading up to the conference.
IACR conference, featuring leading experts in AI, drug development, obesity & nutrition, stem cells, and cancer plasticity. Don’t miss out!
Stay tuned as we spotlight our fantastic speaker lineup leading up to the conference.
Sharing the final version of our review on the complex landscape of luminal breast cancer now published with @stefanprekovic.bsky.social, @catrinlutz.bsky.social, and Hendrik. Available here: doi.org/10.1530/ERC-...
January 8, 2025 at 12:55 PM
Sharing the final version of our review on the complex landscape of luminal breast cancer now published with @stefanprekovic.bsky.social, @catrinlutz.bsky.social, and Hendrik. Available here: doi.org/10.1530/ERC-...
Just Published to close off the year! Our latest work explores the dynamic interplay between ER and HER2 in breast cancer, revealing how treatment drives receptor discordance and impacts clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers
Click on the article title to read more.
onlinelibrary.wiley.com
December 17, 2024 at 3:32 PM
Just Published to close off the year! Our latest work explores the dynamic interplay between ER and HER2 in breast cancer, revealing how treatment drives receptor discordance and impacts clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Damir Vareslija
Irish Association for Cancer Research (IACR) is joining Bsky. Our mission is to connect researchers and promote cancer research in Ireland. Stay tuned for updates on our initiatives and events, including the upcoming IACR Annual Conference.
Let’s advance Irish cancer research! 💡🔬
Let’s advance Irish cancer research! 💡🔬
December 16, 2024 at 11:14 AM
Irish Association for Cancer Research (IACR) is joining Bsky. Our mission is to connect researchers and promote cancer research in Ireland. Stay tuned for updates on our initiatives and events, including the upcoming IACR Annual Conference.
Let’s advance Irish cancer research! 💡🔬
Let’s advance Irish cancer research! 💡🔬
Super interesting study. Glucocorticoids promote glioblastoma growth in a time-of-day-dependent manner. Disrupting daily glucocorticoid signaling reduces GBM growth and progression.
Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...
More: www.cell.com/cancer-cell/...
Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.
www.cell.com
December 12, 2024 at 5:16 PM
Super interesting study. Glucocorticoids promote glioblastoma growth in a time-of-day-dependent manner. Disrupting daily glucocorticoid signaling reduces GBM growth and progression.
Excited to present our lab's latest research on brain metastasis at BACR conference next Monday/Tuesday/Wednesday and seeing some science friends.
November 22, 2024 at 11:16 AM
Excited to present our lab's latest research on brain metastasis at BACR conference next Monday/Tuesday/Wednesday and seeing some science friends.
A Multilineage Screen Identifies Actionable Synthetic Lethal Interactions in Human Cancers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A multilineage screen identifies actionable synthetic lethal interactions in human cancers - Nature Genetics
A framework combining combinatorial CRISPR knockout in breast, lung and oropharyngeal cancer in vitro models with public data identifies synthetic lethal interactions, such as perturbed KDM5C sensitiz...
www.nature.com
November 20, 2024 at 10:13 PM
A Multilineage Screen Identifies Actionable Synthetic Lethal Interactions in Human Cancers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Damir Vareslija
Delighted to report that the publication or our patient work in Irish Metastatic Breast Cancer patients has gone live. www.sciencedirect.com/science/arti...
A patient- led survey on information and communication needs of patients with metastatic breast cancer in Ireland and Northern Ireland (CTRIAL-IE 23-05)
Although treatment advances have improved survival rates for patients with metastatic breast cancer (MBC), patient expressed needs have not been evalu…
www.sciencedirect.com
November 20, 2024 at 11:26 AM
Delighted to report that the publication or our patient work in Irish Metastatic Breast Cancer patients has gone live. www.sciencedirect.com/science/arti...
Sharing a recently published review I did with Prekovic Lab and Cat Lutz, featured in the Emerging Leaders edition of Endocrine-Related Cancer! Nice opportunity to highlight the complexities of luminal breast cancer
erc.bioscientifica.com/view/journal...
erc.bioscientifica.com/view/journal...
erc.bioscientifica.com
November 17, 2024 at 7:30 PM
Sharing a recently published review I did with Prekovic Lab and Cat Lutz, featured in the Emerging Leaders edition of Endocrine-Related Cancer! Nice opportunity to highlight the complexities of luminal breast cancer
erc.bioscientifica.com/view/journal...
erc.bioscientifica.com/view/journal...
Finally caved and joined Bluskye because apparently, academic Twitter is migrating, and I didn’t want to miss the next big thing in posting grants, papers, and my favourite activity sending myself new papers
November 16, 2024 at 8:29 PM
Finally caved and joined Bluskye because apparently, academic Twitter is migrating, and I didn’t want to miss the next big thing in posting grants, papers, and my favourite activity sending myself new papers