Cole McCutcheon
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crm110.bsky.social
Cole McCutcheon
@crm110.bsky.social
130 followers 400 following 13 posts
Postdoc in Coyne Lab @ Duke. Trying to figure out if I’m a microbiologist, immunologist, or reproductive biologist. Probably running or attempting to find a sweet treat.
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Reposted by Cole McCutcheon
plosbiology.org
Probing the evolutionary diversity of placental development: Francesca Soncin explores a @plosbiology.org study that provides a spatial transcriptomic characterization of the porcine #placenta, developing a new swine trophoblast #organoid model 🧪 Paper: plos.io/47jf3yd Primer: plos.io/3HZodFB
A schematic showing the implications of integrative omics studies of placental biology in non-traditional animal models on different fields. The image shows a ring with four quadrants, these representing the farm industry, biomedical research, conservation and pregnancy disorders. Within the ring are icons representing placenta, organoid, scRNA-seq, developmental trajectory and spatial transcriptomics.
September 1, 2025 at 4:44 PM
Reposted by Cole McCutcheon
plosbiology.org
In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd
Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.
September 1, 2025 at 1:26 PM
crm110.bsky.social
Thank to Dr. Francesca Soncin for writing this great primer on our paper! Check it out now on @plosbiology.org
Advancing comparative placentation through spatial transcriptomics and organoid models
More work is needed to characterize the evolutionary diversity of placental development in eutherian mammals. This Primer discusses a recent PLOS Biology study that provides a rich spatial transcripto...
journals.plos.org
August 29, 2025 at 6:06 PM
crm110.bsky.social
Super excited to share my latest paper examining the pig placenta!
August 29, 2025 at 1:42 AM
crm110.bsky.social
Fresh off the press! (Ok two days ago but I missed it…🤷‍♂️). Super proud to have contributed to this great paper led by Macy Pell and Shannon Manning.

journals.asm.org/doi/10.1128/...
Impact of antibiotics on membrane vesicle production in Group B Streptococcus | Microbiology Spectrum
GBS colonization during pregnancy can lead to invasive disease in neonates. Although antibiotics are given to GBS-positive pregnant patients during labor, some of these individuals remain colonized wi...
journals.asm.org
June 11, 2025 at 8:43 PM
Reposted by Cole McCutcheon
becca-casazza.bsky.social
Super excited to share this new preprint from our lab describing the Jamaican fruit bat placenta! 🦇

Here we analyzed the bat placenta by snRNAseq, compared it to the human and murine placenta to identify unique features, and developed bat placental & decidual organoids for use as models!
biorxiv-devbio.bsky.social bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · May 19
Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats https://www.biorxiv.org/content/10.1101/2025.05.15.654282v1
May 19, 2025 at 3:20 PM
crm110.bsky.social
🚨 New pre-print! 🚨 Super excited to be a part of this cool project led by Allyson Caldwell, @becca-casazza.bsky.social and Henry Yang! Who would have thought the bat placenta would be so cool?! 🦇
Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats
Bats maintain pregnancy despite extended gestation relative to other small mammals, high fetal investment, recurrent pathogen exposure, and the metabolic demands of flight. These physiological extreme...
www.biorxiv.org
May 19, 2025 at 2:55 PM
Reposted by Cole McCutcheon
elife.bsky.social
Research on the development, physiology, and pathophysiology of reproduction is of great importance for understanding fertility and health.

Explore the latest in our new #ReproductiveHealth Special Issue.
Special Issue: Reproductive Health
Our latest Special Issue showcases research in reproductive biology and medicine.
buff.ly
February 24, 2025 at 2:47 PM
crm110.bsky.social
Starting off 2025 strong with a new publication! #GBS @acspublications.bsky.social

pubs.acs.org/doi/10.1021/...
Group B Streptococcal Membrane Vesicles Induce Proinflammatory Cytokine Production and Are Sensed in an NLRP3 Inflammasome-Dependent Mechanism in a Human Macrophage-like Cell Line
Group B Streptococcus (GBS) is a major cause of fetal and neonatal mortality worldwide. Many of the adverse effects of invasive GBS are associated with inflammation; therefore, understanding bacterial...
pubs.acs.org
January 6, 2025 at 7:01 PM
Reposted by Cole McCutcheon
natureportfolio.nature.com
A potential new mRNA-based therapy for pre-eclampsia is demonstrated in a mouse study published in Nature. The method involves targeted delivery of mRNA to the placenta to restore normal maternal blood pressure and improve foetal health. 🧪
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia - Nature
A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women's health.
go.nature.com
December 12, 2024 at 8:31 PM