Cornelius Lee
@corneliusleeyh.bsky.social
DPhil student working on influenza in Kapanidis and Fodor lab at University of Oxford. Previously in Vignuzzi lab. A*STAR National Science Scholar.
Reposted by Cornelius Lee
Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 11:02 AM
Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research
Reposted by Cornelius Lee
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 3:17 AM
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Reposted by Cornelius Lee
Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...
High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza
Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in
academic.oup.com
October 16, 2025 at 4:58 PM
Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...
Officially starting my DPhil in Condensed Matter Physics with @achilleskap.bsky.social (@kavlioxford.bsky.social) and @efodor.bsky.social (@dunnschool.bsky.social)! A collaborative project to understand influenza dynamics. Excited to see where this project goes!
October 15, 2025 at 11:18 AM
Officially starting my DPhil in Condensed Matter Physics with @achilleskap.bsky.social (@kavlioxford.bsky.social) and @efodor.bsky.social (@dunnschool.bsky.social)! A collaborative project to understand influenza dynamics. Excited to see where this project goes!
Reposted by Cornelius Lee
What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...
The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent
Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA
academic.oup.com
September 16, 2025 at 9:40 PM
What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...
Reposted by Cornelius Lee
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI
plos.io/3VjfjWI
Why does the m6A writer complex require so many proteins?
Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...
plos.io
September 16, 2025 at 8:48 AM
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI
plos.io/3VjfjWI
Amused by cardiac muscle contraction differentiated from IPSCs ❤️ Super cool isn’t it?
September 15, 2025 at 10:03 AM
Amused by cardiac muscle contraction differentiated from IPSCs ❤️ Super cool isn’t it?
Reposted by Cornelius Lee
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
September 7, 2025 at 8:04 PM
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
Reposted by Cornelius Lee
Last day at @vignuzzilab.bsky.social ! Leaving in The Office style. Been a fruitful journey and definitely grew me scientifically🧬🔬!
August 22, 2025 at 4:55 AM
Last day at @vignuzzilab.bsky.social ! Leaving in The Office style. Been a fruitful journey and definitely grew me scientifically🧬🔬!
Reposted by Cornelius Lee
What a dynamic team they make! This was the official send off for Cornelius heading to Oxford University for his PhD!
August 14, 2025 at 1:12 AM
What a dynamic team they make! This was the official send off for Cornelius heading to Oxford University for his PhD!
Found in my photo album. Beneath their family portrait, a boy looking at his younger brother. A quiet moment in the long legacy of Mount Sinai porters.
August 10, 2025 at 6:39 AM
Found in my photo album. Beneath their family portrait, a boy looking at his younger brother. A quiet moment in the long legacy of Mount Sinai porters.
Happy Birthday Singapore 🇸🇬!
August 9, 2025 at 4:39 PM
Happy Birthday Singapore 🇸🇬!
Late lab nights, vibing to RnB and beautiful DNA/RNA bands ✨
July 29, 2025 at 5:20 PM
Late lab nights, vibing to RnB and beautiful DNA/RNA bands ✨
Another life milestone! Goodbye National University of Singapore ! Been a good one ✨. Excited for the next phase of my life.
July 16, 2025 at 11:41 AM
Another life milestone! Goodbye National University of Singapore ! Been a good one ✨. Excited for the next phase of my life.
First ever poster presentation experience on influenza DVGs! Thanks to the amazing mentors @alnajifg.bsky.social and @vignuzzilab.bsky.social
July 2, 2025 at 5:02 PM
First ever poster presentation experience on influenza DVGs! Thanks to the amazing mentors @alnajifg.bsky.social and @vignuzzilab.bsky.social
Reposted by Cornelius Lee
Congratulations Cornelius, having completed his 1 year research attachment in my lab, this ASTAR Scholar heads out to Oxford University soon to PhD in the biophysics of influenza virus structure and assembly! 👏 👨🎓
July 2, 2025 at 3:45 AM
Congratulations Cornelius, having completed his 1 year research attachment in my lab, this ASTAR Scholar heads out to Oxford University soon to PhD in the biophysics of influenza virus structure and assembly! 👏 👨🎓