Fadi Alnaji
@alnajifg.bsky.social
Virus & Music lover. Currently a postdoc in the Vignuzzi lab at A*STAR, Singapore.
Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 11:02 AM
Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research
Reposted by Fadi Alnaji
Check out @mfarjo.bsky.social's new preprint where she uses a simulation-based approach to explore the evolutionary consequences of genetic mixing through co-infection for segmented viruses:
www.biorxiv.org/content/10.1...
hope you like it!
www.biorxiv.org/content/10.1...
hope you like it!
The fitness consequences of coinfection and reassortment for segmented viruses depend upon viral genetic structure
Cellular coinfection between multiple virions is a common feature of viral infections. The collective virus-virus interactions enabled by these coinfections can influence the fitness of viral populati...
www.biorxiv.org
July 29, 2025 at 8:46 PM
Check out @mfarjo.bsky.social's new preprint where she uses a simulation-based approach to explore the evolutionary consequences of genetic mixing through co-infection for segmented viruses:
www.biorxiv.org/content/10.1...
hope you like it!
www.biorxiv.org/content/10.1...
hope you like it!
Reposted by Fadi Alnaji
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
hr.myu.umn.edu
November 22, 2024 at 6:54 PM
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Reposted by Fadi Alnaji
Check out
@joelrc.bsky.social
's new preprint examining how the seasonal H1N1 and H3N2 lineages of IAV differ in their ability to antagonize IFN induction and signaling, and how these phenotypes have evolved over decades of circulation in humans:
www.biorxiv.org/content/10.1...
@joelrc.bsky.social
's new preprint examining how the seasonal H1N1 and H3N2 lineages of IAV differ in their ability to antagonize IFN induction and signaling, and how these phenotypes have evolved over decades of circulation in humans:
www.biorxiv.org/content/10.1...
Seasonal influenza A virus lineages exhibit divergent abilities to antagonize interferon induction and signaling
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
July 13, 2024 at 3:11 PM
Check out
@joelrc.bsky.social
's new preprint examining how the seasonal H1N1 and H3N2 lineages of IAV differ in their ability to antagonize IFN induction and signaling, and how these phenotypes have evolved over decades of circulation in humans:
www.biorxiv.org/content/10.1...
@joelrc.bsky.social
's new preprint examining how the seasonal H1N1 and H3N2 lineages of IAV differ in their ability to antagonize IFN induction and signaling, and how these phenotypes have evolved over decades of circulation in humans:
www.biorxiv.org/content/10.1...
Reposted by Fadi Alnaji
Fantastic article on the social lives of viruses 🦠 🧪by @carlzimmer.bsky.social featuring work by @asherleeks.bsky.social
and many others www.quantamagazine.org/viruses-fina.... Glad to be wading into this field thanks to @nanamikubota.bsky.social
and many others www.quantamagazine.org/viruses-fina.... Glad to be wading into this field thanks to @nanamikubota.bsky.social
Viruses Finally Reveal Their Complex Social Life | Quanta Magazine
New research has uncovered a social world of viruses full of cheating, cooperation and other intrigues, suggesting that viruses make sense only as members of a community.
www.quantamagazine.org
April 13, 2024 at 3:51 PM
Fantastic article on the social lives of viruses 🦠 🧪by @carlzimmer.bsky.social featuring work by @asherleeks.bsky.social
and many others www.quantamagazine.org/viruses-fina.... Glad to be wading into this field thanks to @nanamikubota.bsky.social
and many others www.quantamagazine.org/viruses-fina.... Glad to be wading into this field thanks to @nanamikubota.bsky.social
Reposted by Fadi Alnaji
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin https://www.biorxiv.org/content/10.1101/2024.03.18.585603v1
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin https://www.biorxiv.org/content/10.1101/2024.03.18.585603v1
The antigenic evolution of the influenza A virus hemagglutinin (HA) gene poses a major challenge for
www.biorxiv.org
March 19, 2024 at 2:17 AM
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin https://www.biorxiv.org/content/10.1101/2024.03.18.585603v1
Very glad to contribute to this collaboration exploring the role of truncated proteins produced by Influenza DelVG during infection.
Very exciting finding: most viruses produce large deletion mutants (DVGs), some of which can spread as cheats. In flu, DVGs often delete > 80% of the genome, so we typically assume they don't encode functional proteins...
doi.org/10.1093/nar/...
(1/2)
doi.org/10.1093/nar/...
(1/2)
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome
Abstract. Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral ge
doi.org
March 6, 2024 at 2:56 PM
Very glad to contribute to this collaboration exploring the role of truncated proteins produced by Influenza DelVG during infection.
Reposted by Fadi Alnaji
Announcing the Social Lives of Viruses 2024!
Do you study social evolution in viruses? Do you want to?
Join us in Puerto Rico this June for a 50-person meeting dedicated to viral sociality. All costs covered.
Apply here: forms.gle/sHTEcHJjryDh...
#ViroSky
#MicroSky
#EvoSky
#SocialViruses
Do you study social evolution in viruses? Do you want to?
Join us in Puerto Rico this June for a 50-person meeting dedicated to viral sociality. All costs covered.
Apply here: forms.gle/sHTEcHJjryDh...
#ViroSky
#MicroSky
#EvoSky
#SocialViruses
January 22, 2024 at 8:34 PM
Announcing the Social Lives of Viruses 2024!
Do you study social evolution in viruses? Do you want to?
Join us in Puerto Rico this June for a 50-person meeting dedicated to viral sociality. All costs covered.
Apply here: forms.gle/sHTEcHJjryDh...
#ViroSky
#MicroSky
#EvoSky
#SocialViruses
Do you study social evolution in viruses? Do you want to?
Join us in Puerto Rico this June for a 50-person meeting dedicated to viral sociality. All costs covered.
Apply here: forms.gle/sHTEcHJjryDh...
#ViroSky
#MicroSky
#EvoSky
#SocialViruses
I am very glad to see this out, beautiful work, congrats @mfarjo.bsky.social 🥳🥳
Excited to *finally* have @mfarjo.bsky.social 's fantastic paper on SARS-CoV-2 within-host evolutionary dynamics during acute infection published at JVI: journals.asm.org/doi/10.1128/...
journals.asm.org
January 10, 2024 at 10:30 PM
I am very glad to see this out, beautiful work, congrats @mfarjo.bsky.social 🥳🥳