Christian Baumann
@cjbaumann.bsky.social
Postdoc in the Fasshauer lab at the University of Lausanne. Computational biology, protein evolution, membrane proteins & NMR.
Reposted by Christian Baumann
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Christian Baumann
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by Christian Baumann
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by Christian Baumann
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 4, 2025 at 5:30 PM
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
Reposted by Christian Baumann
New paper from the Gossert lab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR www.sciencedirect.com/science/arti...
Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR
A wealth of insights into the mechanisms of GPCRs have been gained from biophysical studies of thermostabilized β1 adrenergic receptors (β1AR) from tu…
www.sciencedirect.com
August 31, 2025 at 3:44 PM
New paper from the Gossert lab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR www.sciencedirect.com/science/arti...
Reposted by Christian Baumann
As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET:
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science
www.science.org/doi/10.1126/...
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science
www.science.org/doi/10.1126/...
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...
www.science.org
October 16, 2025 at 10:34 PM
As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET:
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science
www.science.org/doi/10.1126/...
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science
www.science.org/doi/10.1126/...
Reposted by Christian Baumann
Fwd: Fwd: “I hope this email finds you well”
October 7, 2025 at 8:37 AM
Fwd: Fwd: “I hope this email finds you well”
Reposted by Christian Baumann
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
September 29, 2025 at 10:50 AM
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
Reposted by Christian Baumann
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Are Asgard archaea the ancestors of eukaryotes? Likely not. Very insightful paper by @pforterrr.bsky.social
Extensive lateral gene transfer between proto‐eukaryotes and Heimdallarchaeia suggests their close association during eukaryogenesis
It has been proposed by Ettema and colleagues, in the two-domain framework for the tree of life, that Eukarya emerged from Heimdallarchaeia, as sister group to Hodarchaeales. Looking at the individua....
doi.org
September 16, 2025 at 9:17 AM
Are Asgard archaea the ancestors of eukaryotes? Likely not. Very insightful paper by @pforterrr.bsky.social
Getting closer to the year 3000
September 8, 2025 at 1:58 PM
Getting closer to the year 3000
Reposted by Christian Baumann
Did you know your MacBook has a sensor that knows the exact angle of the screen hinge?
It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.
Source code and a downloadable app to try it yourself […]
[Original post on hachyderm.io]
It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.
Source code and a downloadable app to try it yourself […]
[Original post on hachyderm.io]
September 6, 2025 at 8:43 PM
Did you know your MacBook has a sensor that knows the exact angle of the screen hinge?
It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.
Source code and a downloadable app to try it yourself […]
[Original post on hachyderm.io]
It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.
Source code and a downloadable app to try it yourself […]
[Original post on hachyderm.io]
Sounds very neat:
OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes - ScienceDirect share.google/yPJkioKNph4m...
OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes - ScienceDirect share.google/yPJkioKNph4m...
OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes
Molecular dynamics (MD) simulations in explicit lipid bilayers enable modeling of protein-lipid interactions essential for membrane protein functions …
share.google
July 24, 2025 at 3:20 PM
Sounds very neat:
OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes - ScienceDirect share.google/yPJkioKNph4m...
OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes - ScienceDirect share.google/yPJkioKNph4m...
Reposted by Christian Baumann
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
July 23, 2025 at 11:40 AM
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
Reposted by Christian Baumann
The peer review process is a flawless system that has no issues whatsoever /s
July 22, 2025 at 3:13 PM
The peer review process is a flawless system that has no issues whatsoever /s
Reposted by Christian Baumann
Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...
#NMRchat
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
July 22, 2025 at 2:54 AM
Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...
#NMRchat
www.pnas.org/doi/10.1073/...
The Vatican now takes a stronger stand for science than the US government:
www.nature.com/articles/d41...
www.pas.va/en/events/20...
www.nature.com/articles/d41...
www.pas.va/en/events/20...
Concerned about freedom of science and truth
Letter to the Editor
www.nature.com
June 30, 2025 at 6:53 AM
The Vatican now takes a stronger stand for science than the US government:
www.nature.com/articles/d41...
www.pas.va/en/events/20...
www.nature.com/articles/d41...
www.pas.va/en/events/20...
Reposted by Christian Baumann
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
The Missing 11th of the Month - David R Hagen
Personal website of David R Hagen, scientific software engineer
drhagen.com
June 19, 2025 at 11:40 AM
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
Reposted by Christian Baumann
#lipidtime The proteolipid code is the ultimate membrane model. It accommodates all observations while also being a falsifiable scientific theory that rejects the status quo (lipid rafts, picket fences, etc.)
doi.org/10.1186/s129...
Please read it.
doi.org/10.1186/s129...
Please read it.
Membranes are functionalized by a proteolipid code - BMC Biology
Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones...
doi.org
April 3, 2025 at 3:53 PM
#lipidtime The proteolipid code is the ultimate membrane model. It accommodates all observations while also being a falsifiable scientific theory that rejects the status quo (lipid rafts, picket fences, etc.)
doi.org/10.1186/s129...
Please read it.
doi.org/10.1186/s129...
Please read it.
For everyone interested in how membrane thickness differs between and within organelles, by @deglushk.bsky.social, S. Böhm & M. Beck: www.biorxiv.org/content/10.1...
www.biorxiv.org
June 10, 2025 at 1:19 PM
For everyone interested in how membrane thickness differs between and within organelles, by @deglushk.bsky.social, S. Böhm & M. Beck: www.biorxiv.org/content/10.1...
Reposted by Christian Baumann
At times like these it's important to remember the 3 branches of science
May 26, 2025 at 10:04 PM
At times like these it's important to remember the 3 branches of science
Reposted by Christian Baumann
It’s Mary Anning’s birthday, so time to share @katebeaton.bsky.social’s brilliant cartoon again.
May 21, 2025 at 11:31 AM
It’s Mary Anning’s birthday, so time to share @katebeaton.bsky.social’s brilliant cartoon again.
Huge congrats to the authors for pulling this off:
Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes | Science www.science.org/doi/full/10....
Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes | Science www.science.org/doi/full/10....
www.science.org
May 19, 2025 at 6:30 AM
Huge congrats to the authors for pulling this off:
Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes | Science www.science.org/doi/full/10....
Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes | Science www.science.org/doi/full/10....