Chris Whelan
chrisdwhelan.bsky.social
Chris Whelan
@chrisdwhelan.bsky.social
Director of Neuroscience Data Science at J&J. Interested in population proteomics, genetics, neuroscience & biomarker development. 🇮🇪🧠🧬
I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study.

www.ukbiobank.ac.uk/learn-more-a...
Launch of world’s most significant protein study set to usher in new understanding for medicine
www.ukbiobank.ac.uk
January 10, 2025 at 8:18 AM
Reposted by Chris Whelan
Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)
December 12, 2024 at 6:14 AM
Reposted by Chris Whelan
Could be combined in the future with a continuous sensor (implant) for real-time detection of proteins driving inflammation in high-risk individuals
www.science.org/doi/10.1126/...
@science.org
Active-reset protein sensors enable continuous in vivo monitoring of inflammation
Continuous measurement of proteins in vivo is important for real-time disease management and prevention. Implantable sensors for monitoring small molecules such as glucose have been available for more...
www.science.org
December 11, 2024 at 7:54 PM
Reposted by Chris Whelan
Here we tried to provide some objective views to the reoccurring discussion:

pubs.acs.org/doi/10.1021/...

The key is to understand the biases and factors causing the differences in the data. Those can include and do go beyond the antibodies.
The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends
Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest in using these novel methods for studying the ...
pubs.acs.org
November 21, 2024 at 9:33 AM
Loved participating in the ‘Advancing Multi-Omics to the Clinic’ meeting in beautiful Sydney this week.

Fascinating talks from several KOLs (see photos for Ruedi Aebersold’s revised Central Dogma of Biology) & lots of encouraging interplay between mass spectrometry and affinity-based proteomics.
November 20, 2024 at 7:52 AM