Casey Gifford
@caseygifford.bsky.social
Assistant Professor @ Stanford
Reposted by Casey Gifford
The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!
Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contexts
Multiplexed assays of variant effect (MAVEs) systematically measure variant function but have been limited to cancer cell lines rather than disease-relevant cell types. We developed saturation genome ...
www.medrxiv.org
November 22, 2025 at 1:49 AM
The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!
About 7 weeks ago, I told my lab that #ultima_genomics was willing to sequence cardiac organoid multiomes delivered by June 30. Josh, Megha and Lucy said… GAME.ON. And well, today they delivered 59 from various hiPSC lines, conditions and time points 💪🥳🧬 So proud of them for stepping up!
July 1, 2025 at 4:34 AM
About 7 weeks ago, I told my lab that #ultima_genomics was willing to sequence cardiac organoid multiomes delivered by June 30. Josh, Megha and Lucy said… GAME.ON. And well, today they delivered 59 from various hiPSC lines, conditions and time points 💪🥳🧬 So proud of them for stepping up!
Reposted by Casey Gifford
Frost: Tonight the people stealing are not folks with tattoos and hoodies but people wearing suits and ties and congressional pins sitting in the capitol now, not in some alley wrapped in darkness but the United States congress wrapped in the flag. It is disgusting and we will never forget this.
May 22, 2025 at 4:05 AM
Frost: Tonight the people stealing are not folks with tattoos and hoodies but people wearing suits and ties and congressional pins sitting in the capitol now, not in some alley wrapped in darkness but the United States congress wrapped in the flag. It is disgusting and we will never forget this.
Reposted by Casey Gifford
Reposted by Casey Gifford
All NSF GRFPs to students choosing to attend Harvard in the Fall were just terminated
May 22, 2025 at 7:38 PM
All NSF GRFPs to students choosing to attend Harvard in the Fall were just terminated
Reposted by Casey Gifford
Bullying students and schools to provoke fear and silence dissent is how we trade democracy and freedom for authoritarianism. This will affect nearly a third of Harvard's students. We cannot be silent.
May 22, 2025 at 8:17 PM
Bullying students and schools to provoke fear and silence dissent is how we trade democracy and freedom for authoritarianism. This will affect nearly a third of Harvard's students. We cannot be silent.
Reposted by Casey Gifford
NSF GRFPs terminated for those in graduate school and already attending Harvard, too.
All NSF GRFPs to students choosing to attend Harvard in the Fall were just terminated
May 22, 2025 at 8:31 PM
NSF GRFPs terminated for those in graduate school and already attending Harvard, too.
Vote for Megha Agarwal’s cardiac organoid ‘STEMCELLfie’ 🔬🧫❤️⭐️🤩 www.stemcell.com/stemcellfie
Magnifying the Beauty of Science!
Enter your best cell image by April 16th.
www.stemcell.com
April 28, 2025 at 6:42 PM
Vote for Megha Agarwal’s cardiac organoid ‘STEMCELLfie’ 🔬🧫❤️⭐️🤩 www.stemcell.com/stemcellfie
Reposted by Casey Gifford
Go California! Please write to your representatives in the California Senate and ask them to support Mr. Scott Wiener's Bill.
www.politico.com/news/2025/03...
www.politico.com/news/2025/03...
Fearing Trump cuts, California Democrat proposes creating state’s own NIH
The ambitious state lawmaker argues moves by Elon Musk and Robert F. Kennedy Jr. show the Golden State must “step up” as a global leader.
www.politico.com
March 27, 2025 at 11:21 PM
Go California! Please write to your representatives in the California Senate and ask them to support Mr. Scott Wiener's Bill.
www.politico.com/news/2025/03...
www.politico.com/news/2025/03...
Reposted by Casey Gifford
Look what's happening at the French Embassy in Washington DC.
March 4, 2025 at 9:05 PM
Look what's happening at the French Embassy in Washington DC.
Reposted by Casey Gifford
NEW: Senator Marshall (R-KS) RUNS AWAY, fleeing his own town hall after being asked about DOGE firing Veterans. MAKE HIM GO VIRAL.
March 1, 2025 at 6:21 PM
NEW: Senator Marshall (R-KS) RUNS AWAY, fleeing his own town hall after being asked about DOGE firing Veterans. MAKE HIM GO VIRAL.
Reposted by Casey Gifford
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️
www.rarediseaseday.org
www.rarediseaseday.org
Rare Disease Day 2025 – Raising awareness for people living with rare diseases and their families worldwide.
www.rarediseaseday.org
March 1, 2025 at 3:56 AM
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️
www.rarediseaseday.org
www.rarediseaseday.org
Reposted by Casey Gifford
NEW: A searing editorial in the The Kyiv Independent.
“It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
“A president just disrespected America in the Oval Office. It wasn’t Zelensky.”
@kyivindependent.com
“It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
“A president just disrespected America in the Oval Office. It wasn’t Zelensky.”
@kyivindependent.com
Editorial: A president just disrespected America in the Oval Office. It wasn’t Zelensky
It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
In the past several weeks, the U.S. leadership has demonstrate...
kyivindependent.com
February 28, 2025 at 10:45 PM
NEW: A searing editorial in the The Kyiv Independent.
“It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
“A president just disrespected America in the Oval Office. It wasn’t Zelensky.”
@kyivindependent.com
“It’s time to say it plainly. America’s leadership has switched sides in the war. The American people have not, and they should speak up.
“A president just disrespected America in the Oval Office. It wasn’t Zelensky.”
@kyivindependent.com
Reposted by Casey Gifford
Most #PhD scientists in the United States stay in the labor force notably longer than the average person—into their late 60s and in some cases beyond—according to new data from the National Science Foundation. scim.ag/4knpeWn
Why do so many retirement-age scientists keep working?
Survey reveals a desire to hold onto their professional identity keeps Ph.D.s working beyond their 60s
scim.ag
February 28, 2025 at 2:31 PM
Most #PhD scientists in the United States stay in the labor force notably longer than the average person—into their late 60s and in some cases beyond—according to new data from the National Science Foundation. scim.ag/4knpeWn
Reposted by Casey Gifford
Graduating during the pandemic slowed down my process and is part of why I did two postdocs. Now as a first year faculty, all the federal grants are frozen. I love the work I do but this has all of us questioning how much www.science.org/content/arti...
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
www.science.org
February 24, 2025 at 11:26 PM
Graduating during the pandemic slowed down my process and is part of why I did two postdocs. Now as a first year faculty, all the federal grants are frozen. I love the work I do but this has all of us questioning how much www.science.org/content/arti...
Reposted by Casey Gifford
Reposted by Casey Gifford
A freeze on meetings of expert panels that peer review grant proposals at the National Institutes of Health is kicking in this week.
Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi
Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
scim.ag
February 19, 2025 at 6:18 PM
A freeze on meetings of expert panels that peer review grant proposals at the National Institutes of Health is kicking in this week.
Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi
Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi
Reposted by Casey Gifford
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Reposted by Casey Gifford
#WomeninSTEM accelerate science and make our work possible. Today, we join other science organizations around the world by recognizing the International Day of Women and Girls in Science. #WomenInScienceDay
February 11, 2025 at 9:03 PM
#WomeninSTEM accelerate science and make our work possible. Today, we join other science organizations around the world by recognizing the International Day of Women and Girls in Science. #WomenInScienceDay
Reposted by Casey Gifford
Just got the dreaded email. University of Iowa is halting all NIH grant submissions.
Losing a generation of scientists here will send the state backwards. What a travesty.
Losing a generation of scientists here will send the state backwards. What a travesty.
February 10, 2025 at 10:14 PM
Just got the dreaded email. University of Iowa is halting all NIH grant submissions.
Losing a generation of scientists here will send the state backwards. What a travesty.
Losing a generation of scientists here will send the state backwards. What a travesty.
Reposted by Casey Gifford
"Maybe impostor syndrome wasn’t a sign of failure, but a sign of growth."
This week's #ScienceWorkingLife. https://scim.ag/3QbA5oF
This week's #ScienceWorkingLife. https://scim.ag/3QbA5oF
February 10, 2025 at 3:07 PM
"Maybe impostor syndrome wasn’t a sign of failure, but a sign of growth."
This week's #ScienceWorkingLife. https://scim.ag/3QbA5oF
This week's #ScienceWorkingLife. https://scim.ag/3QbA5oF
Reposted by Casey Gifford
President Trump ended a first-of-its-kind assessment of land, water and wildlife across the U.S. that its leader called "too important to die," weeks before the study was set to be completed.
Trump Killed a Major Report on Nature. They’re Trying to Publish It Anyway.
The first full draft of the assessment, on the state of America’s land, water and wildlife, was weeks from completion. The project leader called the study “too important to die.”
www.nytimes.com
February 10, 2025 at 3:56 PM
President Trump ended a first-of-its-kind assessment of land, water and wildlife across the U.S. that its leader called "too important to die," weeks before the study was set to be completed.
Reposted by Casey Gifford
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted by Casey Gifford
Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
A genome-wide atlas of human cell morphology - Nature Methods
An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...
www.nature.com
January 27, 2025 at 6:23 PM
Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
Reposted by Casey Gifford
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
January 15, 2025 at 5:05 PM
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...