Çagla Tükel
@caglatukel.bsky.social
Professor of Microbiology, immunology and inflammation. Interested in host-biofilm interactions, bacterial amyloid curli and microbial pathogenesis
Two weeks two PhD defenses from Tukel lab. Congratulations to Drs Kaitlyn Grando and Shingo Bessho. So proud with both of their accomplishments @kaiterwaul.bsky.social @besshoshingo.bsky.social
September 4, 2025 at 11:17 PM
Two weeks two PhD defenses from Tukel lab. Congratulations to Drs Kaitlyn Grando and Shingo Bessho. So proud with both of their accomplishments @kaiterwaul.bsky.social @besshoshingo.bsky.social
Reposted by Çagla Tükel
It’s happening!!!
August 3, 2025 at 9:47 PM
It’s happening!!!
Listened to some great talks, delivered a talk, received good feedback and spent good time with friends #ASMMicrobe. Time to say goodbye to LA
June 23, 2025 at 3:15 PM
Listened to some great talks, delivered a talk, received good feedback and spent good time with friends #ASMMicrobe. Time to say goodbye to LA
Reposted by Çagla Tükel
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
June 3, 2025 at 4:40 PM
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Reposted by Çagla Tükel
CHECK IT OUT 🦠👀
Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment
www.quantamagazine.org/how-a-biofil...
Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment
www.quantamagazine.org/how-a-biofil...
April 21, 2025 at 6:30 PM
CHECK IT OUT 🦠👀
Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment
www.quantamagazine.org/how-a-biofil...
Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment
www.quantamagazine.org/how-a-biofil...
Proud of my student Kaitlyn Grando @kaiterwaul.bsky.social Her work and accomplishments were featured in Katz news #Temple. medicine.temple.edu/news/2025/02...
Kaitlyn Grando’s Groundbreaking Work in Biofilm Research
medicine.temple.edu
April 3, 2025 at 5:14 PM
Proud of my student Kaitlyn Grando @kaiterwaul.bsky.social Her work and accomplishments were featured in Katz news #Temple. medicine.temple.edu/news/2025/02...
Beautiful review by @abaumler discussing the factors that contribute to gut microbiota assembly
🔬🦠 How to make sense of the taxonomic complexity & interpersonal variability of the gut microbiota? We propose that beneath this complexity lies a hierarchy of factors that control gut microbiota assembly. Read more! #Microbiome #GutHealth
authors.elsevier.com/a/1km32_,2Ci...
authors.elsevier.com/a/1km32_,2Ci...
March 15, 2025 at 1:33 AM
Beautiful review by @abaumler discussing the factors that contribute to gut microbiota assembly
Very happy to be a part of this beautiful study led by Drs Maria Cimini and Raj Kishore showing a role for SAA3 amyloidosis after myocardial infarction (MI) and how SAA3 loaded exosomes can drive injury
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction
Cardiac amyloidosis is a secondary phenomenon of an already pre-existing chronic condition. Whether cardiac amyloidosis represents one of the complica…
www.sciencedirect.com
March 13, 2025 at 3:58 PM
Very happy to be a part of this beautiful study led by Drs Maria Cimini and Raj Kishore showing a role for SAA3 amyloidosis after myocardial infarction (MI) and how SAA3 loaded exosomes can drive injury
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Çagla Tükel
Local traditional media still works!
We shot this interview on the grounds of the former J&L steel mill, where buildings including my lab are today. The threat to biomedical research in Pittsburgh is on par with the threat to the mills 50 years ago.
www.wtae.com/article/pitt...
We shot this interview on the grounds of the former J&L steel mill, where buildings including my lab are today. The threat to biomedical research in Pittsburgh is on par with the threat to the mills 50 years ago.
www.wtae.com/article/pitt...
Pittsburgh researcher warns NIH cuts could harm patient care, economic growth
Pittsburgh's economy once relied heavily on the steel industry, which lined Second Avenue with miles of mills. When that industry collapsed, medicine and education filled the economic void.
www.wtae.com
February 28, 2025 at 1:52 AM
Local traditional media still works!
We shot this interview on the grounds of the former J&L steel mill, where buildings including my lab are today. The threat to biomedical research in Pittsburgh is on par with the threat to the mills 50 years ago.
www.wtae.com/article/pitt...
We shot this interview on the grounds of the former J&L steel mill, where buildings including my lab are today. The threat to biomedical research in Pittsburgh is on par with the threat to the mills 50 years ago.
www.wtae.com/article/pitt...
Reposted by Çagla Tükel
Studies show that funding from the National Institutes of Health (NIH) contributed to 354 of 356 drugs (99.4%) approved by the FDA from 2010 to 2019. Recklessly slashing NIH funding will mean that patients will be waiting much longer for life-saving treatments.
February 24, 2025 at 7:21 PM
Studies show that funding from the National Institutes of Health (NIH) contributed to 354 of 356 drugs (99.4%) approved by the FDA from 2010 to 2019. Recklessly slashing NIH funding will mean that patients will be waiting much longer for life-saving treatments.
Reposted by Çagla Tükel
Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science."
"The weeks ahead may be the greatest test that the US scientific community has ever faced"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"The weeks ahead may be the greatest test that the US scientific community has ever faced"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
February 24, 2025 at 7:38 PM
Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science."
"The weeks ahead may be the greatest test that the US scientific community has ever faced"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"The weeks ahead may be the greatest test that the US scientific community has ever faced"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
Reposted by Çagla Tükel
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 22, 2025 at 6:39 PM
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
Reposted by Çagla Tükel
On March 7th we will Stand Up For Science! You can use the link to find the protest location in your city.
standupforscience2025.org
standupforscience2025.org
February 23, 2025 at 2:43 PM
On March 7th we will Stand Up For Science! You can use the link to find the protest location in your city.
standupforscience2025.org
standupforscience2025.org
Reposted by Çagla Tükel
Reposted by Çagla Tükel
Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment https://www.biorxiv.org/content/10.1101/2025.02.10.637339v1
February 14, 2025 at 11:49 PM
Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment https://www.biorxiv.org/content/10.1101/2025.02.10.637339v1
Reposted by Çagla Tükel
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."
February 11, 2025 at 3:18 PM
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."
Reposted by Çagla Tükel
Threats to the NIH and our research infrastructure hit me twice- once as a scientist, and again as a patient whose next option will be a clinical trial. Remember that there are real people’s lives at stake.
a phone case that says " do n't forget me " next to a phone
ALT: a phone case that says " do n't forget me " next to a phone
media.tenor.com
February 12, 2025 at 3:17 AM
Threats to the NIH and our research infrastructure hit me twice- once as a scientist, and again as a patient whose next option will be a clinical trial. Remember that there are real people’s lives at stake.
Reposted by Çagla Tükel
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
February 11, 2025 at 7:52 AM
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
My graduate student @besshoshingo.bsky.social gave an oral presentation on the role of Type I IFNs and Salmonella mediated autoimmunity at #MAMPM. Thank you organizers for a wonderful meeting in beautiful VA @lawrenzlab.bsky.social @davislabjhu.bsky.social
February 7, 2025 at 5:53 PM
My graduate student @besshoshingo.bsky.social gave an oral presentation on the role of Type I IFNs and Salmonella mediated autoimmunity at #MAMPM. Thank you organizers for a wonderful meeting in beautiful VA @lawrenzlab.bsky.social @davislabjhu.bsky.social
Congratulations to my student Kaitlyn Grando @kaiterwaul.bsky.social for being awarded Dr. Mark Shirtliff award for excellence in biofilm research. Thank you MAMPM.org #MAMPM
February 3, 2025 at 8:28 PM
Congratulations to my student Kaitlyn Grando @kaiterwaul.bsky.social for being awarded Dr. Mark Shirtliff award for excellence in biofilm research. Thank you MAMPM.org #MAMPM
Reposted by Çagla Tükel
January 23, 2025 at 10:56 PM
Golden age of antibiotics
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly.
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
December 23, 2024 at 1:08 PM
Golden age of antibiotics
Reposted by Çagla Tükel
From the S. Shin lab sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella. doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation | mBio
Inflammasomes are essential for host defense against intracellular bacterial pathogens
like Legionella, as they activate caspases, which promote cytokine release and cell death to control
infection. I...
doi.org
November 13, 2024 at 12:32 PM
From the S. Shin lab sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella. doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Reposted by Çagla Tükel
