birdflustocks
@birdflustocks.bsky.social
The H5N1 avian influenza pandemic risk from a financial perspective.
Reposted by birdflustocks
As the accursed ostrich situation continues to get simultaneously more stupid and gravely serious, I decided to write up a very long analysis of many of the key issues. Bottom line: so long as this flock lives, it is a threat to Canada's national security. 🧵
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
Last Stand in Bird Flu Ostrich Land
The BC ostrich convoy enters the "find out" stage of FAFO and so have we all
open.substack.com
October 5, 2025 at 10:25 PM
As the accursed ostrich situation continues to get simultaneously more stupid and gravely serious, I decided to write up a very long analysis of many of the key issues. Bottom line: so long as this flock lives, it is a threat to Canada's national security. 🧵
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
Reposted by birdflustocks
Los Angeles cat H5N1 deaths prompt new warning about raw pet food
Samples available for one of the cats revealed the B3.13 genotype, and genetic sequencing at the USDA lab is underway.
www.cidrap.umn.edu/a...
Samples available for one of the cats revealed the B3.13 genotype, and genetic sequencing at the USDA lab is underway.
www.cidrap.umn.edu/a...
September 26, 2025 at 6:28 PM
Los Angeles cat H5N1 deaths prompt new warning about raw pet food
Samples available for one of the cats revealed the B3.13 genotype, and genetic sequencing at the USDA lab is underway.
www.cidrap.umn.edu/a...
Samples available for one of the cats revealed the B3.13 genotype, and genetic sequencing at the USDA lab is underway.
www.cidrap.umn.edu/a...
Reposted by birdflustocks
NVSL has uploaded 112 sets of #H5N1 seqs to GISAID
Largely from wild birds or Dairy Herds
Dairy Herds were B3.13 with PB2 K670R
Two Harbor Seal seqs were D1.1 w/ PB2 E627K
A/harbor seal/USA/019393-001/2025
One Red Fox seq was D1.1 w/ PB2 D701N
A/red fox/USA/019397-001/2025
Largely from wild birds or Dairy Herds
Dairy Herds were B3.13 with PB2 K670R
Two Harbor Seal seqs were D1.1 w/ PB2 E627K
A/harbor seal/USA/019393-001/2025
One Red Fox seq was D1.1 w/ PB2 D701N
A/red fox/USA/019397-001/2025
July 31, 2025 at 11:40 AM
NVSL has uploaded 112 sets of #H5N1 seqs to GISAID
Largely from wild birds or Dairy Herds
Dairy Herds were B3.13 with PB2 K670R
Two Harbor Seal seqs were D1.1 w/ PB2 E627K
A/harbor seal/USA/019393-001/2025
One Red Fox seq was D1.1 w/ PB2 D701N
A/red fox/USA/019397-001/2025
Largely from wild birds or Dairy Herds
Dairy Herds were B3.13 with PB2 K670R
Two Harbor Seal seqs were D1.1 w/ PB2 E627K
A/harbor seal/USA/019393-001/2025
One Red Fox seq was D1.1 w/ PB2 D701N
A/red fox/USA/019397-001/2025
Reposted by birdflustocks
Nature Communications || Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin–Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates
Nina Patel et al
H5N1
www.nature.com/articles/s41...
Nina Patel et al
H5N1
www.nature.com/articles/s41...
Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin–Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates - Nature Communications
The rise in highly pathogenic avian influenza cases elevates the risk of human-to-human transmission. Here, the authors develop an adjuvanted protein-based vaccine that elicits robust antibody- and ce...
www.nature.com
July 20, 2025 at 10:01 PM
Nature Communications || Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin–Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates
Nina Patel et al
H5N1
www.nature.com/articles/s41...
Nina Patel et al
H5N1
www.nature.com/articles/s41...
#H5N1 #influenza
Single doses of 450mg, 300mg and 150mg of CD388 conferred 76%, 61% and 58% protection, respectively, from symptomatic influenza over 24 weeks compared to placebo
CD388 was well-tolerated with no safety signals observed
www.cidara.com/news/cidara-...
Single doses of 450mg, 300mg and 150mg of CD388 conferred 76%, 61% and 58% protection, respectively, from symptomatic influenza over 24 weeks compared to placebo
CD388 was well-tolerated with no safety signals observed
www.cidara.com/news/cidara-...
June 23, 2025 at 11:39 AM
#H5N1 #influenza
Single doses of 450mg, 300mg and 150mg of CD388 conferred 76%, 61% and 58% protection, respectively, from symptomatic influenza over 24 weeks compared to placebo
CD388 was well-tolerated with no safety signals observed
www.cidara.com/news/cidara-...
Single doses of 450mg, 300mg and 150mg of CD388 conferred 76%, 61% and 58% protection, respectively, from symptomatic influenza over 24 weeks compared to placebo
CD388 was well-tolerated with no safety signals observed
www.cidara.com/news/cidara-...
Reposted by birdflustocks
Partial mink #H5N1 D1.1 seq has PB2 E627K
A/mink/USA/010686-001-tile/2025
Closely related to bear seqs w/ PB2 E627K
A/bear/USA/008592-001/2025
A/bear/USA/008592-002/2025
A/bear/USA/008592-003/2025
A/mink/USA/010686-001-tile/2025
Closely related to bear seqs w/ PB2 E627K
A/bear/USA/008592-001/2025
A/bear/USA/008592-002/2025
A/bear/USA/008592-003/2025
June 3, 2025 at 4:45 PM
Partial mink #H5N1 D1.1 seq has PB2 E627K
A/mink/USA/010686-001-tile/2025
Closely related to bear seqs w/ PB2 E627K
A/bear/USA/008592-001/2025
A/bear/USA/008592-002/2025
A/bear/USA/008592-003/2025
A/mink/USA/010686-001-tile/2025
Closely related to bear seqs w/ PB2 E627K
A/bear/USA/008592-001/2025
A/bear/USA/008592-002/2025
A/bear/USA/008592-003/2025
Reposted by birdflustocks
NVSL uploaded 140 sets of #H5N1 seqs from wild birds, mammals, and Dairy Herds
Included in the dairy herd seqs were more B3.13 seqs with PB2 E627K w/ K670R
Not included was a closely related seq at Genbank
A/cattle/CA/25-010012-003-original/2025 | 3/18/25
w/PB2 E627K (from CA)
Included in the dairy herd seqs were more B3.13 seqs with PB2 E627K w/ K670R
Not included was a closely related seq at Genbank
A/cattle/CA/25-010012-003-original/2025 | 3/18/25
w/PB2 E627K (from CA)
May 27, 2025 at 12:59 AM
NVSL uploaded 140 sets of #H5N1 seqs from wild birds, mammals, and Dairy Herds
Included in the dairy herd seqs were more B3.13 seqs with PB2 E627K w/ K670R
Not included was a closely related seq at Genbank
A/cattle/CA/25-010012-003-original/2025 | 3/18/25
w/PB2 E627K (from CA)
Included in the dairy herd seqs were more B3.13 seqs with PB2 E627K w/ K670R
Not included was a closely related seq at Genbank
A/cattle/CA/25-010012-003-original/2025 | 3/18/25
w/PB2 E627K (from CA)
Reposted by birdflustocks
Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice - npj Viruses
npj Viruses - Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
www.nature.com
May 23, 2025 at 4:02 PM
Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by birdflustocks
#H5N1 B3.13 Dairy Herds w/ PB2 E627K
increased to 11
partial PB2 seq was uploaded earlier this week for
A/dairy cow/USA/001948-005-R/2025
two did not have PB2 seq but
other segments matched the 9 farms with E627K
A/dairy cow/USA/010012-003/2025
A/dairy cow/USA/010022-002/2025
increased to 11
partial PB2 seq was uploaded earlier this week for
A/dairy cow/USA/001948-005-R/2025
two did not have PB2 seq but
other segments matched the 9 farms with E627K
A/dairy cow/USA/010012-003/2025
A/dairy cow/USA/010022-002/2025
April 12, 2025 at 8:09 PM
#H5N1 B3.13 Dairy Herds w/ PB2 E627K
increased to 11
partial PB2 seq was uploaded earlier this week for
A/dairy cow/USA/001948-005-R/2025
two did not have PB2 seq but
other segments matched the 9 farms with E627K
A/dairy cow/USA/010012-003/2025
A/dairy cow/USA/010022-002/2025
increased to 11
partial PB2 seq was uploaded earlier this week for
A/dairy cow/USA/001948-005-R/2025
two did not have PB2 seq but
other segments matched the 9 farms with E627K
A/dairy cow/USA/010012-003/2025
A/dairy cow/USA/010022-002/2025
Reposted by birdflustocks
Arcturus Therapeutics Receives U.S. FDA Fast Track Designation for the STARR® mRNA Vaccine Candidate ARCT-2304 for Pandemic Influenza A Virus H5N1
ir.arcturusrx.com/news-release...
ir.arcturusrx.com/news-release...
Arcturus Therapeutics Receives U.S. FDA Fast Track Designation for the STARR® mRNA Vaccine Candidate ARCT-2304 for Pandemic Influenza A Virus H5N1 | Arcturus Therapeutics, Inc.
SAN DIEGO --(BUSINESS WIRE)--Apr. 10, 2025-- Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a commercial messenger RNA medicine company focused on the development of in...
ir.arcturusrx.com
April 12, 2025 at 3:34 AM
Arcturus Therapeutics Receives U.S. FDA Fast Track Designation for the STARR® mRNA Vaccine Candidate ARCT-2304 for Pandemic Influenza A Virus H5N1
ir.arcturusrx.com/news-release...
ir.arcturusrx.com/news-release...
Media of WHO meeting now online: What research is important to prepare and respond to H5N1 influenza outbreaks?
20 presentations and 6 hours of video of the recent WHO meeting are available here:
www.who.int/news-room/ev...
#H5N1 #influenza #birdflu #pandemic
20 presentations and 6 hours of video of the recent WHO meeting are available here:
www.who.int/news-room/ev...
#H5N1 #influenza #birdflu #pandemic
www.who.int
April 1, 2025 at 10:28 AM
Media of WHO meeting now online: What research is important to prepare and respond to H5N1 influenza outbreaks?
20 presentations and 6 hours of video of the recent WHO meeting are available here:
www.who.int/news-room/ev...
#H5N1 #influenza #birdflu #pandemic
20 presentations and 6 hours of video of the recent WHO meeting are available here:
www.who.int/news-room/ev...
#H5N1 #influenza #birdflu #pandemic
Reposted by birdflustocks
NEW: UK detects bird flu in sheep for the first time
Authorities play down risks to livestock but urge precautions to avoid mass outbreaks seen in US
www.ft.com/content/66d0... via @financialtimes.com
Register here to read some FT articles free:
www.ft.com/register
Authorities play down risks to livestock but urge precautions to avoid mass outbreaks seen in US
www.ft.com/content/66d0... via @financialtimes.com
Register here to read some FT articles free:
www.ft.com/register
UK detects bird flu in sheep for the first time
Authorities play down risks to livestock but urge precautions to avoid mass outbreaks seen in US
www.ft.com
March 24, 2025 at 10:04 AM
NEW: UK detects bird flu in sheep for the first time
Authorities play down risks to livestock but urge precautions to avoid mass outbreaks seen in US
www.ft.com/content/66d0... via @financialtimes.com
Register here to read some FT articles free:
www.ft.com/register
Authorities play down risks to livestock but urge precautions to avoid mass outbreaks seen in US
www.ft.com/content/66d0... via @financialtimes.com
Register here to read some FT articles free:
www.ft.com/register
Reposted by birdflustocks
Human OH case
A/Ohio/06-1/2025 | 2/12/24
#H5N1 D1.3
N1 is exact match (1410/1410)
many of OH and IN poultry farms
with another larger series at
1409/1410
The total number of matches is about 125 N1 seqs
all are chicken or turkey farms
D1.3 has ARRIVED
LONG spring expected
A/Ohio/06-1/2025 | 2/12/24
#H5N1 D1.3
N1 is exact match (1410/1410)
many of OH and IN poultry farms
with another larger series at
1409/1410
The total number of matches is about 125 N1 seqs
all are chicken or turkey farms
D1.3 has ARRIVED
LONG spring expected
March 19, 2025 at 6:36 PM
Human OH case
A/Ohio/06-1/2025 | 2/12/24
#H5N1 D1.3
N1 is exact match (1410/1410)
many of OH and IN poultry farms
with another larger series at
1409/1410
The total number of matches is about 125 N1 seqs
all are chicken or turkey farms
D1.3 has ARRIVED
LONG spring expected
A/Ohio/06-1/2025 | 2/12/24
#H5N1 D1.3
N1 is exact match (1410/1410)
many of OH and IN poultry farms
with another larger series at
1409/1410
The total number of matches is about 125 N1 seqs
all are chicken or turkey farms
D1.3 has ARRIVED
LONG spring expected
Reposted by birdflustocks
March 19, 2025 at 5:37 PM
Reposted by birdflustocks
I have put up quite a few D1.3 seqs (designated "not assigned")
The 2025 commercial farms don't have state or collection dates but vast majority are IN or OH
most or all 2025 turkey or chicken farms are D1.3
many wild bird seqs are D1.3
spring migration is just beginning
I expect D1.3 to dominate
The 2025 commercial farms don't have state or collection dates but vast majority are IN or OH
most or all 2025 turkey or chicken farms are D1.3
many wild bird seqs are D1.3
spring migration is just beginning
I expect D1.3 to dominate
March 17, 2025 at 3:05 AM
I have put up quite a few D1.3 seqs (designated "not assigned")
The 2025 commercial farms don't have state or collection dates but vast majority are IN or OH
most or all 2025 turkey or chicken farms are D1.3
many wild bird seqs are D1.3
spring migration is just beginning
I expect D1.3 to dominate
The 2025 commercial farms don't have state or collection dates but vast majority are IN or OH
most or all 2025 turkey or chicken farms are D1.3
many wild bird seqs are D1.3
spring migration is just beginning
I expect D1.3 to dominate
Reposted by birdflustocks
The number of #H5N1 D1.3 seqs at GISAID is very large (genotype is "not designated")
The large number of 2025 chicken and turkey seqs indicates the outbreaks in IN and OH are included
some seqs named at Genbank incl/
A/chicken/OH/25-000474-002-original/2025
www.ncbi.nlm.nih.gov/nuccore?Link...
The large number of 2025 chicken and turkey seqs indicates the outbreaks in IN and OH are included
some seqs named at Genbank incl/
A/chicken/OH/25-000474-002-original/2025
www.ncbi.nlm.nih.gov/nuccore?Link...
March 17, 2025 at 9:34 AM
The number of #H5N1 D1.3 seqs at GISAID is very large (genotype is "not designated")
The large number of 2025 chicken and turkey seqs indicates the outbreaks in IN and OH are included
some seqs named at Genbank incl/
A/chicken/OH/25-000474-002-original/2025
www.ncbi.nlm.nih.gov/nuccore?Link...
The large number of 2025 chicken and turkey seqs indicates the outbreaks in IN and OH are included
some seqs named at Genbank incl/
A/chicken/OH/25-000474-002-original/2025
www.ncbi.nlm.nih.gov/nuccore?Link...
"Taken together, the preclinical data reported here highlight the potential for the use of CD388 as a universal long-acting therapeutic for the treatment and prevention of seasonal and pandemic influenza in both healthy and high-risk individuals."
www.nature.com/articles/s41...
#H5N1 #influenza
www.nature.com/articles/s41...
#H5N1 #influenza
Drug–Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice - Nature Microbiology
CD388 is a first-in-class antiviral drug–Fc conjugate engineered for extended half-life that demonstrates potent prophylactic and therapeutic efficacy against lethal influenza A and B challenge in mic...
www.nature.com
March 17, 2025 at 1:18 PM
"Taken together, the preclinical data reported here highlight the potential for the use of CD388 as a universal long-acting therapeutic for the treatment and prevention of seasonal and pandemic influenza in both healthy and high-risk individuals."
www.nature.com/articles/s41...
#H5N1 #influenza
www.nature.com/articles/s41...
#H5N1 #influenza
Reposted by birdflustocks
ALERT
#H5N1 D1.3 appears to be widespread
will rise significantly near term
It is in wild birds
poultry in multiple states
incl/ 2025 poultry USA seqs (IN & OH)
D1.3 is
D1.1 which swapped American N1 for Eurasian A3
Genotype labeled in GISAID as "not assigned"
American = PB1 PA NP
#H5N1 D1.3 appears to be widespread
will rise significantly near term
It is in wild birds
poultry in multiple states
incl/ 2025 poultry USA seqs (IN & OH)
D1.3 is
D1.1 which swapped American N1 for Eurasian A3
Genotype labeled in GISAID as "not assigned"
American = PB1 PA NP
March 16, 2025 at 11:56 PM
ALERT
#H5N1 D1.3 appears to be widespread
will rise significantly near term
It is in wild birds
poultry in multiple states
incl/ 2025 poultry USA seqs (IN & OH)
D1.3 is
D1.1 which swapped American N1 for Eurasian A3
Genotype labeled in GISAID as "not assigned"
American = PB1 PA NP
#H5N1 D1.3 appears to be widespread
will rise significantly near term
It is in wild birds
poultry in multiple states
incl/ 2025 poultry USA seqs (IN & OH)
D1.3 is
D1.1 which swapped American N1 for Eurasian A3
Genotype labeled in GISAID as "not assigned"
American = PB1 PA NP
Reposted by birdflustocks
Hogvet51: Nevada Dairy Cattle Tentatively Infected with H5N1 2.3.4.4b D1.1 open.substack.com/pub/hogvet51...
Nevada Dairy Cattle Tentatively Infected with H5N1 2.3.4.4b D1.1
Cases listed on NVSL web site apparently of the D1.1 genotype
open.substack.com
February 3, 2025 at 11:26 PM
Hogvet51: Nevada Dairy Cattle Tentatively Infected with H5N1 2.3.4.4b D1.1 open.substack.com/pub/hogvet51...
More than 100 avian influenza expert opinions!
www.birdflustocks.com#expert-opini...
#H5N1 #birdflu #pandemic
www.birdflustocks.com#expert-opini...
#H5N1 #birdflu #pandemic
January 31, 2025 at 2:32 AM
More than 100 avian influenza expert opinions!
www.birdflustocks.com#expert-opini...
#H5N1 #birdflu #pandemic
www.birdflustocks.com#expert-opini...
#H5N1 #birdflu #pandemic