Benjamin Weekley, Ph.D.
@benjaminweekley.bsky.social
Postdoc in the Maze Lab studying neuroepigenetics |
PhD from USC in the Rice Lab studying histone tail proteolysis
PhD from USC in the Rice Lab studying histone tail proteolysis
Reposted by Benjamin Weekley, Ph.D.
Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!
You can register at: us06web.zoom.us/webinar/regi...
You can register at: us06web.zoom.us/webinar/regi...
May 15, 2025 at 6:35 PM
Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!
You can register at: us06web.zoom.us/webinar/regi...
You can register at: us06web.zoom.us/webinar/regi...
Reposted by Benjamin Weekley, Ph.D.
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Been a great couple of days of fantastic talks at @embl.org in Heidelberg! Presented a poster, and have thoroughly enjoyed learning about all the great epigenetics research going on and making lots of new friends!! #EMBLChromatin
May 16, 2025 at 8:26 AM
Been a great couple of days of fantastic talks at @embl.org in Heidelberg! Presented a poster, and have thoroughly enjoyed learning about all the great epigenetics research going on and making lots of new friends!! #EMBLChromatin
Reposted by Benjamin Weekley, Ph.D.
🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM
March 28, 2025 at 3:44 PM
🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM
Reposted by Benjamin Weekley, Ph.D.
Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree...
Montreal is an amazing city and the Lady Davis is a great institute to work at!
Montreal is an amazing city and the Lady Davis is a great institute to work at!
Assistant Professor (Research), Department of Anatomy and Cell Biology (C1-250306)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
March 27, 2025 at 5:25 PM
Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree...
Montreal is an amazing city and the Lady Davis is a great institute to work at!
Montreal is an amazing city and the Lady Davis is a great institute to work at!
Enjoyed writing this review on classic & emerging techniques being used to elucidate neuroepigenetic mechanisms using biochemistry, chemical and molecular biology in both in vitro/vivo models, with a focus on how these can drive therapeutic strategies in the near future.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders
Therapeutics; Epigenetics; Neuroscience
www.cell.com
March 26, 2025 at 1:16 PM
Enjoyed writing this review on classic & emerging techniques being used to elucidate neuroepigenetic mechanisms using biochemistry, chemical and molecular biology in both in vitro/vivo models, with a focus on how these can drive therapeutic strategies in the near future.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Benjamin Weekley, Ph.D.
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Transfer RNA acetylation regulates in vivo mammalian stress signaling
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
www.science.org
March 20, 2025 at 1:42 AM
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Benjamin Weekley, Ph.D.
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Benjamin Weekley, Ph.D.
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Reposted by Benjamin Weekley, Ph.D.
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
investors.beamtx.com
March 10, 2025 at 11:48 AM
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
Reposted by Benjamin Weekley, Ph.D.
🥁We are just 3 days away from our next #FragileNucleosome seminar! We are delighted to host, 2 amazing ECR researchers @rachelhoffman.bsky.social & @jonmarkert.bsky.social this Wed!
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...
March 10, 2025 at 1:28 PM
🥁We are just 3 days away from our next #FragileNucleosome seminar! We are delighted to host, 2 amazing ECR researchers @rachelhoffman.bsky.social & @jonmarkert.bsky.social this Wed!
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...
Reposted by Benjamin Weekley, Ph.D.
I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!
Our first recruit struggled initially to succeed in obtaining NIH funding. But her science was/is terrific and we bridged her along. She subsequent received an HHMI appointment, and then substantial NIH funding. She is now a member of the National Academy and is the current department director
25/n
25/n
March 9, 2025 at 4:14 PM
I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!
Reposted by Benjamin Weekley, Ph.D.
At the #StandUpforScience protest in NYC—several hundred people turned out to Washington Square Park today to protest Trump’s cuts to public research
March 7, 2025 at 6:23 PM
At the #StandUpforScience protest in NYC—several hundred people turned out to Washington Square Park today to protest Trump’s cuts to public research
Reposted by Benjamin Weekley, Ph.D.
Maze lab at #standupforscience NYC! cut gels not funding!! 🧬
March 7, 2025 at 8:48 PM
Maze lab at #standupforscience NYC! cut gels not funding!! 🧬
March 7, 2025 at 8:39 PM
Reposted by Benjamin Weekley, Ph.D.
SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!
To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
March 6, 2025 at 7:14 PM
SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!
To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
Reposted by Benjamin Weekley, Ph.D.
Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them!
@standupforscience.bsky.social
@standupforscience.bsky.social
March 3, 2025 at 6:22 PM
Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them!
@standupforscience.bsky.social
@standupforscience.bsky.social
I will be at the Stand Up for Science NYC event on Friday! Calling all NYC and New York area based scientists to join!!
NYC! 📣🗽☀️
We’re Standing Up for Science in Washington Square Park on March 7th from 12-3 PM!
Share with someone in NYC who should show up & support Science! ⬇️
#standupforscience2025
We’re Standing Up for Science in Washington Square Park on March 7th from 12-3 PM!
Share with someone in NYC who should show up & support Science! ⬇️
#standupforscience2025
March 4, 2025 at 5:51 PM
I will be at the Stand Up for Science NYC event on Friday! Calling all NYC and New York area based scientists to join!!
Reposted by Benjamin Weekley, Ph.D.
Mechanism for local attenuation of DNA replication at double-strand breaks @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 19, 2025 at 6:54 PM
Mechanism for local attenuation of DNA replication at double-strand breaks @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Benjamin Weekley, Ph.D.
Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 20, 2025 at 7:42 AM
Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇
Reposted by Benjamin Weekley, Ph.D.
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
Computational design of serine hydrolases
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...
scim.ag
February 18, 2025 at 3:08 PM
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
Reposted by Benjamin Weekley, Ph.D.
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
February 16, 2025 at 11:25 PM
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
Reposted by Benjamin Weekley, Ph.D.
