Michael Roach
beardymcjohnface.bsky.social
Michael Roach
@beardymcjohnface.bsky.social
He/him; bioinformatician; enthusiast brewer and certified beer judge; running stuff on your head node.
Reposted by Michael Roach
🦧📉 Why are there colorful apes in my #dataviz workshops?

📸 The photo taken years ago by my friend Richard Strozynski has become a tradition in my client projects and courses.

I like to recolor it with different palettes to show how palette design affects perception.

Thread 👇
October 28, 2025 at 4:32 PM
Reposted by Michael Roach
ABACBS/BioC Asia 2025 Workshops are coming! @ Adelaide 27-28 November.

Join us in November for two days of deep-dive sessions on scalable bioinformatics, spatial omics, AI-driven genomics, and more

blackochrelabs.au/abacbs2025_w...

#Bioinformatics @abacbs.bsky.social @bioconductor.bsky.social
October 14, 2025 at 12:46 AM
Reposted by Michael Roach
i have to say, as a trans journalist who has covered the "trans debate" for about a decade now, there is no daylight between how the trump administration and conservatives lie about tylenol and autism and how they've lied about youth trans care.
September 23, 2025 at 12:32 PM
Reposted by Michael Roach
After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.
Let’s be clear about what happened to Jimmy Kimmel
Trump’s most brazen attack on free speech yet.
www.yahoo.com
September 18, 2025 at 2:10 PM
Reposted by Michael Roach
Yesterday's piece from @jamellebouie.net is the only high-profile piece I've seen that specifically discusses the watchlist, its effect on academics, and its effect on public attitudes toward academia as a whole. (gift link)

www.nytimes.com/2025/09/13/o...
September 14, 2025 at 3:10 PM
Reposted by Michael Roach
🚨New Review Out🚨
We explore how phage-antibiotic synergy can dismantle efflux-driven resistance in multidrug-resistant ESKAPEE pathogens. By reprogramming bacterial defences, phages offer a precision strategy to restore antibiotic efficacy.

journals.asm.org/doi/10.1128/...
Reprogramming resistance: phage-antibiotic synergy targets efflux systems in ESKAPEE pathogens | mBio
Antimicrobial resistance (AMR) is one of the greatest threats to global health. If unaddressed, it is projected to cause over 39 million cumulative deaths globally by 2050 (1). While resistance is a b...
journals.asm.org
September 9, 2025 at 3:24 AM
Reposted by Michael Roach
🚨 New preprint 🚨

My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky

www.biorxiv.org/content/10.1...
Synteny-aware functional annotation of bacteriophage genomes with Phynteny
Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...
www.biorxiv.org
July 30, 2025 at 6:01 AM
Reposted by Michael Roach
LeGO-Teknik reveals that the neurogenesis pathway is a clone-specific hallmark of brain metastasis in breast cancer https://www.biorxiv.org/content/10.1101/2025.07.23.666035v1
July 27, 2025 at 10:48 AM
Reposted by Michael Roach
PhD opportunities at @flindersuniversity.bsky.social in Adelaide, Australia's most liveable city, to study genetics in #phage

We will also have genetics #postdoc positions too!

#microsky #phagesky

www.linkedin.com/pulse/phd-pr...
PhD Project: Discovering Novel Mechanisms of Phage Genome Evolution
We are looking for an awesome PhD student to join our research team to investigate how bacteriophages (phages) generate targeted mutations that enable them to evolve and infect new bacterial hosts. Yo...
www.linkedin.com
July 7, 2025 at 8:23 AM
Reposted by Michael Roach
We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social
We made structural predictions of representatives of each #PHROG from #phage genomes, and put the whole lot online. You can browse through montages or go to your favourite phrog directly and download its PDB.

💻🧬 #phagesky

linsalrob.github.io/PHROG_struct...
PHROG Structure Gallery
linsalrob.github.io
July 7, 2025 at 8:49 AM
Reposted by Michael Roach
Very honoured and excited to have been awarded an ARC Laureate Fellowship today. Exciting things to come!

#FL25

rms.arc.gov.au/RMS/Report/D...
Research Management System - Scheme Round Statistics for Approved Applications - Australian Laureate Fellowships 2025 round 1
RMS is the ARC's Research Management System, a web-based system used by eligible researchers to prepare and submit research proposals and assessments under the ARC National Competitive Grants Program ...
rms.arc.gov.au
June 26, 2025 at 1:33 AM
Reposted by Michael Roach
Manuscript out now in Briefings in Bioinformatics!

TaxSEA: rapid interpretation of microbiome alterations using taxon set enrichment analysis and public databases. #microbiome #metagenomics
academic.oup.com/bib/article/...
My first R package is officially out Bioconductor 3.21 today 🎉
TaxSEA adapts GSEA-style methods for metagenomic data— useful for interpreting differential abundance results. Manuscript accepted & in-press. Check it out bioconductor.org/packages/rel...
#Bioinformatics #Metagenomics #RStats
TaxSEA
TaxSEA is an R package for Taxon Set Enrichment Analysis, which utilises a Kolmogorov-Smirnov test analyses to investigate differential abundance analysis output for whether there are alternations in ...
bioconductor.org
April 22, 2025 at 12:23 AM
Reposted by Michael Roach
Excited to share my first JOSS publication 🎉 Snk: A #Snakemake CLI and Workflow Management System joss.theoj.org/papers/10.21...
Snk: A Snakemake CLI and Workflow Management System
Wirth et al., (2024). Snk: A Snakemake CLI and Workflow Management System. Journal of Open Source Software, 9(103), 7410, https://doi.org/10.21105/joss.07410
joss.theoj.org
November 26, 2024 at 1:07 AM
Reposted by Michael Roach
🎉 Excited to introduce #SPHAE! Our new workflow for phage genome analysis generates complete genomes, annotations, & comprehensive summaries of genome features. Check it out: github.com/linsalrob/sphae #phagesky @linsalrob.bsky.social
GitHub - linsalrob/sphae: NEW!!! Phage annotations and predictions. A spae is a prediction or forete...
NEW!!! Phage annotations and predictions. A spae is a prediction or foretelling. We'll foretell you what your phage is doing! - GitHub - linsalrob/sphae: NEW!!! Phage annotations and prediction...
github.com
December 13, 2023 at 4:02 AM
Do invite codes just accumulate over time?
November 22, 2023 at 12:07 AM