ASolmonson
@asolmonson.bsky.social
Assistant Professor @UTSW Green Center for Reproductive Biology
Placenta Biology and Developmental Metabolism
Placenta Biology and Developmental Metabolism
Reposted by ASolmonson
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 11:37 PM
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
Not surprised that @rjdlab.bsky.social and Zheng put this beautiful story together. Congrats guys!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 12:47 AM
Not surprised that @rjdlab.bsky.social and Zheng put this beautiful story together. Congrats guys!
Reposted by ASolmonson
It's not in this article but the government asserts that the sandwich was thrown at "point blank range", which implies subway sandwiches have defined effective weapon ranges of varying lethality, and I would like to see the government's chart of these ranges.
Trial Begins for Man Accused of Lobbing a Sandwich at a Federal Agent www.nytimes.com/2025/11/03/u...
Trial Begins for Man Accused of Lobbing a Sandwich at a Federal Agent
www.nytimes.com
November 3, 2025 at 9:14 PM
It's not in this article but the government asserts that the sandwich was thrown at "point blank range", which implies subway sandwiches have defined effective weapon ranges of varying lethality, and I would like to see the government's chart of these ranges.
Reposted by ASolmonson
Just caught up on this fascinating paper in Science in August. It reports evidence of strong selective pressure from breeding of horses around 5000-3000 years ago in Central Asia. One reason it's interesting is that the selection is *really* strong... /1
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Selection at the GSDMC locus in horses and its implications for human mobility
Horsepower revolutionized human history through enhanced mobility, transport, and warfare. However, the suite of biological traits that reshaped horses during domestication remains unclear. We scanned...
www.science.org
October 2, 2025 at 7:46 PM
Just caught up on this fascinating paper in Science in August. It reports evidence of strong selective pressure from breeding of horses around 5000-3000 years ago in Central Asia. One reason it's interesting is that the selection is *really* strong... /1
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by ASolmonson
Earlier this year, ProPublica found that the sepsis rate in second-trimester pregnancy loss hospitalizations increased by more than 50% under Texas’ abortion ban.
Here’s how we did our analysis.
(Published Feb. 2025)
Here’s how we did our analysis.
(Published Feb. 2025)
Texas Won’t Study How Its Abortion Ban Impacts Women, So We Did
Since Texas banned abortion, no one has studied the statewide effects on pregnant women experiencing complications. Here’s how we sifted through data on millions of pregnancy hospitalizations and anal...
www.propublica.org
September 21, 2025 at 1:00 AM
Earlier this year, ProPublica found that the sepsis rate in second-trimester pregnancy loss hospitalizations increased by more than 50% under Texas’ abortion ban.
Here’s how we did our analysis.
(Published Feb. 2025)
Here’s how we did our analysis.
(Published Feb. 2025)
A clean quad is a good quad
September 21, 2025 at 1:37 AM
A clean quad is a good quad
I’ve said it before and I’ll say it again, the Cheers theme song is fitting for really any time in life….including our current timeline
“Making your way in the world today
Takes everything you've got
Taking a break from all your worries
Sure would help a lot
Wouldn't you like to get away?”
“Making your way in the world today
Takes everything you've got
Taking a break from all your worries
Sure would help a lot
Wouldn't you like to get away?”
a group of men wearing sunglasses are standing next to each other in a living room .
ALT: a group of men wearing sunglasses are standing next to each other in a living room .
media.tenor.com
September 20, 2025 at 3:08 AM
I’ve said it before and I’ll say it again, the Cheers theme song is fitting for really any time in life….including our current timeline
“Making your way in the world today
Takes everything you've got
Taking a break from all your worries
Sure would help a lot
Wouldn't you like to get away?”
“Making your way in the world today
Takes everything you've got
Taking a break from all your worries
Sure would help a lot
Wouldn't you like to get away?”
Reposted by ASolmonson
Reposted by ASolmonson
jesus christ
Q: Do you think it would've been fitting to lower the flags to half staff when Melissa Hortman, the Minnesota House Speaker, was gunned down by an assassin?
TRUMP: I'm not familiar. The who?
TRUMP: I'm not familiar. The who?
September 15, 2025 at 10:12 PM
jesus christ
Never Forget
September 11, 2025 at 12:15 AM
Never Forget
Reposted by ASolmonson
have to say that i liked this one quite a bit
wrote about the “national conservative” vision for america
Opinion | They Don’t Want to Live in Lincoln’s America
www.nytimes.com
September 10, 2025 at 11:06 PM
have to say that i liked this one quite a bit
I look at this man and I see neurological “challenges” what should we do about that…
wtf is this nonsense? He thinks he can understand kid’s “mitochondrial challenges” just by looking at them?
This is an insane person.
This is an insane person.
August 28, 2025 at 6:13 AM
I look at this man and I see neurological “challenges” what should we do about that…
Reposted by ASolmonson
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share!
@uofunuip.bsky.social
@uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah, Department of Nutrition & Integrative Physiology | 12844064
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
www.nature.com
August 27, 2025 at 11:05 PM
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share!
@uofunuip.bsky.social
@uofunuip.bsky.social
Reposted by ASolmonson
August 13, 2025 at 1:20 AM
Our lab has derived over 50 trophoblast organoid lines to better understand how chronic conditions like hypertension and obesity influence placental development and metabolism. (Check out this figure made with @biorender.bsky.social)
August 4, 2025 at 1:57 PM
Our lab has derived over 50 trophoblast organoid lines to better understand how chronic conditions like hypertension and obesity influence placental development and metabolism. (Check out this figure made with @biorender.bsky.social)
Reposted by ASolmonson
Happy to share our work on the role of biomechanical PULSATILITY on lung vessels.
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Pulsatile flow dynamics determine pulmonary arterial architecture
BACKGROUND Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries wit...
www.biorxiv.org
August 1, 2025 at 11:25 AM
Happy to share our work on the role of biomechanical PULSATILITY on lung vessels.
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD
Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️🩹
www.biorxiv.org/content/10.1...
Reposted by ASolmonson
Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology
Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...
www.nature.com
July 30, 2025 at 12:16 PM
Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by ASolmonson
1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by @walterwchen.bsky.social and a dream team of collaborators, as explained below. www.nature.com/articles/s41...
PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology
Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...
www.nature.com
July 30, 2025 at 2:04 PM
1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by @walterwchen.bsky.social and a dream team of collaborators, as explained below. www.nature.com/articles/s41...
Reposted by ASolmonson
Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.
July 29, 2025 at 5:59 PM
Excited to share our work just published in @natmetabolism.nature.com examining melanoma tumor metabolism in patients and how well this is (and isn’t) conserved in patient-derived xenograft models.
Reposted by ASolmonson
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 29, 2025 at 2:56 PM
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by ASolmonson
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
jobs.sciencecareers.org
July 21, 2025 at 7:25 PM
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Reposted by ASolmonson
More #Fluorescence Friday from the Mouse Development, Stem Cells & Cancer course @cshlcourses.bsky.social! E9.5 labeled with Shh (magenta), Sox9 (yellow), DAPI (cyan) using @hcrimaging.bsky.social. Image taken by student Roberta Fiorino using Nikon AX R with @oxfordinstruments.bsky.social Imaris.
June 20, 2025 at 7:39 PM
More #Fluorescence Friday from the Mouse Development, Stem Cells & Cancer course @cshlcourses.bsky.social! E9.5 labeled with Shh (magenta), Sox9 (yellow), DAPI (cyan) using @hcrimaging.bsky.social. Image taken by student Roberta Fiorino using Nikon AX R with @oxfordinstruments.bsky.social Imaris.
Reposted by ASolmonson
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.
June 16, 2025 at 9:46 PM
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.