Arutha K
@aruthak.bsky.social
ClinicaloMx Lab Head, Frazer Institute, UQ. Scientific Director, Qld Spatial Biology Centre (views my own)
Reposted by Arutha K
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics
This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.
www.nature.com
October 15, 2025 at 7:28 AM
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics
This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.
www.nature.com
October 11, 2025 at 7:33 PM
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social
Reposted by Arutha K
📢The September issue of @natgenet.nature.com is out!
Featuring:
✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome
&more!
⬇️
www.nature.com/ng/volumes/5...
Featuring:
✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome
&more!
⬇️
www.nature.com/ng/volumes/5...
September 15, 2025 at 11:46 AM
📢The September issue of @natgenet.nature.com is out!
Featuring:
✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome
&more!
⬇️
www.nature.com/ng/volumes/5...
Featuring:
✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome
&more!
⬇️
www.nature.com/ng/volumes/5...
PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays url: academic.oup.com/nargab/artic...
PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays
Abstract. Tissue microarrays (TMAs) enable researchers to analyse hundreds of tissue samples simultaneously by embedding multiple samples into single array
academic.oup.com
August 22, 2025 at 7:08 AM
PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays url: academic.oup.com/nargab/artic...
Plasma proteomics offers a non-invasive approach to monitor dynamic changes in tumour and immune signatures in non-small cell lung cancer (NSCLC). www.researchsquare.com/article/rs-7...
Dissecting Non-Small Cell Lung Cancer (NSCLC) with Blood Proteomics - From Surgical to Immunotherapeutic Responses
Objectives.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited biomarkers to guide surgical and immunotherapeutic intervention. This study aimed to id...
www.researchsquare.com
August 1, 2025 at 9:45 PM
Plasma proteomics offers a non-invasive approach to monitor dynamic changes in tumour and immune signatures in non-small cell lung cancer (NSCLC). www.researchsquare.com/article/rs-7...
Reposted by Arutha K
Did you catch the Queensland Spatial Biology Centre (QSBC) on Channel 9?
@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.
@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.
Researchers' world-first breakthrough on profiling cancer tissue | 9 News Australia
YouTube video by 9 News Australia
www.youtube.com
July 2, 2025 at 12:25 AM
Did you catch the Queensland Spatial Biology Centre (QSBC) on Channel 9?
@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.
@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.
Reposted by Arutha K
Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...
Beyond cell atlases: spatial biology reveals mechanisms behind disease - Nature Biotechnology
As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research.
www.nature.com
May 21, 2025 at 12:51 PM
Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...
Reposted by Arutha K
A/Prof Arutha Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) presented his lab's latest research at the SelectScience Cancer Research Summit. Watch the webinar💻 www.selectscience.net/video/deciph...
#cancerresearch #research #spatialbiology #spatialresearch
#cancerresearch #research #spatialbiology #spatialresearch
Deciphering the complexities in the tumour microenvironment, one cell at a time
In this presentation, Dr. Arutha Kulasinghe discusses how his team uses AI and spatial biology to develop predictive biomarkers for cancer immunotherapy.
www.selectscience.net
May 12, 2025 at 6:16 AM
A/Prof Arutha Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) presented his lab's latest research at the SelectScience Cancer Research Summit. Watch the webinar💻 www.selectscience.net/video/deciph...
#cancerresearch #research #spatialbiology #spatialresearch
#cancerresearch #research #spatialbiology #spatialresearch
Reposted by Arutha K
The QSBC team have presented cutting-edge #cancerresearch findings at the world’s largest #cancer #research conference in Chicago this past week, highlighting how immune cells can block the body’s response to #immunotherapy in aggressive head & neck cancers.
@aruthak.bsky.social
@aruthak.bsky.social
May 2, 2025 at 5:05 AM
The QSBC team have presented cutting-edge #cancerresearch findings at the world’s largest #cancer #research conference in Chicago this past week, highlighting how immune cells can block the body’s response to #immunotherapy in aggressive head & neck cancers.
@aruthak.bsky.social
@aruthak.bsky.social
We are excited to share that our newest spatial method, SM3DD! This is a cell segmentation / annotation-free approach for interpreting 3D Spatial Transcriptomics. Preprint: www.biorxiv.org/cgi/content/...
https://biorxiv.org/content/10.110…
April 19, 2025 at 7:20 AM
We are excited to share that our newest spatial method, SM3DD! This is a cell segmentation / annotation-free approach for interpreting 3D Spatial Transcriptomics. Preprint: www.biorxiv.org/cgi/content/...
Reposted by Arutha K
Their recent tissue-imaging research reveals how the tumour environment, metabolic activity,& immune cells influence patient survival. This groundbreaking work can pave the way for new therapies for one of the deadliest cancers affecting women and people with ovaries today. (2/4)
April 11, 2025 at 7:36 AM
Their recent tissue-imaging research reveals how the tumour environment, metabolic activity,& immune cells influence patient survival. This groundbreaking work can pave the way for new therapies for one of the deadliest cancers affecting women and people with ovaries today. (2/4)
Reposted by Arutha K
🎉New cutting-edge research on ovarian cancer 🎉
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)
April 11, 2025 at 7:36 AM
🎉New cutting-edge research on ovarian cancer 🎉
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)
Reposted by Arutha K
This stunning image, captured by Queensland Spatial Biology Centre (QSBC) scientists using the Wesley Research Institute Phenocycler, has won the prestigious 2025 National Health and Medical Research Council (NHMRC) Science to Art Award!
@aruthak.bsky.social
#spatialmapping #research #science
@aruthak.bsky.social
#spatialmapping #research #science
Queensland Scientists Win Prestigious NHMRC Science to Art Award - Wesley Research Institute
A breathtaking image capturing the intricate details of skin cancer has earned the Queensland Spatial Biology Centre (QSBC) scientists the prestigious 2025 National Health and Medical Research Council...
wesleyresearch.org.au
March 27, 2025 at 11:47 PM
This stunning image, captured by Queensland Spatial Biology Centre (QSBC) scientists using the Wesley Research Institute Phenocycler, has won the prestigious 2025 National Health and Medical Research Council (NHMRC) Science to Art Award!
@aruthak.bsky.social
#spatialmapping #research #science
@aruthak.bsky.social
#spatialmapping #research #science
Reposted by Arutha K
Do you want to know how mechanical interaction between tissue layers controls the formation of complex organ shapes in plants? 🔬🌼
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3
Mechanical interactions between tissue layers underlie plant morphogenesis
Nature Plants - Anthers, the male reproductive organs in plants, are a model to explore the establishment of complex three-dimensional shapes. Live imaging, genetics and modelling reveal an active...
rdcu.be
March 26, 2025 at 2:22 PM
Do you want to know how mechanical interaction between tissue layers controls the formation of complex organ shapes in plants? 🔬🌼
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3
Reposted by Arutha K
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Reposted by Arutha K
A/Prof Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) featured in the Australian Weekend Magazine. He unpacks the advanced imaging techniques utilised by his team, that provide unprecedented insight into immune cells’ responses to cancers. bit.ly/3DOFJdH
March 17, 2025 at 6:16 AM
A/Prof Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) featured in the Australian Weekend Magazine. He unpacks the advanced imaging techniques utilised by his team, that provide unprecedented insight into immune cells’ responses to cancers. bit.ly/3DOFJdH
Checkout today's issue of The Australian Weekend Magazine!
March 15, 2025 at 4:23 AM
Checkout today's issue of The Australian Weekend Magazine!
Reposted by Arutha K
The inimitable @aruthak.bsky.social !
In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research
#spatialmapping #research
Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...
translational-medicine.biomedcentral.com
February 17, 2025 at 10:40 AM
The inimitable @aruthak.bsky.social !
Reposted by Arutha K
In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research
#spatialmapping #research
Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...
translational-medicine.biomedcentral.com
February 17, 2025 at 4:33 AM
In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research
#spatialmapping #research
Reposted by Arutha K
@aruthak.bsky.social and team at the University of Queensland have performed spatial interaction mapping in head & neck cancer patient samples, using a combination of spatial proteomics from Akoya and Navinci’s isPLA
Read the article here: translational-medicine.biomedcentral.com/articles/10....
Read the article here: translational-medicine.biomedcentral.com/articles/10....
Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine
Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...
translational-medicine.biomedcentral.com
February 13, 2025 at 5:54 PM
@aruthak.bsky.social and team at the University of Queensland have performed spatial interaction mapping in head & neck cancer patient samples, using a combination of spatial proteomics from Akoya and Navinci’s isPLA
Read the article here: translational-medicine.biomedcentral.com/articles/10....
Read the article here: translational-medicine.biomedcentral.com/articles/10....
🧬 Exciting New #SpatialAnalysis Tool! 🧬
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...
December 24, 2024 at 7:18 AM
🧬 Exciting New #SpatialAnalysis Tool! 🧬
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...
Reposted by Arutha K
@Aruthak.bsky.social Yes! The #JEDIs are Innovating & JOE YEONG is pulling us together & time not issue 4 this dedicated group still on a hi from #multiomics2024 /10pm #UK, 6am #Singapore & #Taipei, 8am #AU , 2pm #OR #SpatialMedicine #SpatialCatchUps #SpatialInnovation #FinishCancer #cancer
December 19, 2024 at 5:57 AM
@Aruthak.bsky.social Yes! The #JEDIs are Innovating & JOE YEONG is pulling us together & time not issue 4 this dedicated group still on a hi from #multiomics2024 /10pm #UK, 6am #Singapore & #Taipei, 8am #AU , 2pm #OR #SpatialMedicine #SpatialCatchUps #SpatialInnovation #FinishCancer #cancer
Reposted by Arutha K
Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
One of the Multi-Omics O.G.s, @alexswarbrick.bsky.social from @garvaninstitute.bsky.social, speaking on charting an atlas of #cancer #ecosystems with single-cell and spatial omics #multiomics2024
Finished talk with an appeal to join @bsky.app
Finished talk with an appeal to join @bsky.app
December 5, 2024 at 1:31 AM
Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Reposted by Arutha K
#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version.
Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio
Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio
December 6, 2024 at 1:33 AM
#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version.
Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio
Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio
Reposted by Arutha K
What an incredible evening at the #MultiOmics2024 Gala Dinner! What I heard aptly described as "the largest convening of kings behind spatial biology and multi-omics—right here in Brisbane!"
Our video was well-recieved #philanthropyinaction
Our video was well-recieved #philanthropyinaction
December 2, 2024 at 9:54 PM
What an incredible evening at the #MultiOmics2024 Gala Dinner! What I heard aptly described as "the largest convening of kings behind spatial biology and multi-omics—right here in Brisbane!"
Our video was well-recieved #philanthropyinaction
Our video was well-recieved #philanthropyinaction