Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately opti...

Regulatory ubiquitylation of ribosomes is emerging as a key theme in translational regulation and quality control. Ford et al. review how distinct ribosomal ubiquitylation events regulate ribosome-associated quality control pathways at various stages of translation while also highlighting the open questions in the field.

De Siqueira et al. explore the effects of rosiglitazone on adipose stem cell plasticity, showing that PPARγ stimulates expression of ribosomal factors in adipocyte precursors. This leads to translatio...