Anna Schapiro
@annaschapiro.bsky.social
Associate Prof at U Penn. Learning, memory, sleep, neural network modeling...
Reposted by Anna Schapiro
Our digest this week is focused on the NIH budget in congress. There are lots of details to understand that we try to summarize. theprincipledinvestigator.substack.com/p/the-princi...
The Principled Investigator - January 23, 2026
Weekly digest
theprincipledinvestigator.substack.com
January 24, 2026 at 4:23 AM
Our digest this week is focused on the NIH budget in congress. There are lots of details to understand that we try to summarize. theprincipledinvestigator.substack.com/p/the-princi...
Reposted by Anna Schapiro
Our experiences have countless details, and it can be hard to know which matter.
How can we behave effectively in the future when, right now, we don't know what we'll need?
Out today in @nathumbehav.nature.com , @marcelomattar.bsky.social and I find that people solve this by using episodic memory.
How can we behave effectively in the future when, right now, we don't know what we'll need?
Out today in @nathumbehav.nature.com , @marcelomattar.bsky.social and I find that people solve this by using episodic memory.
Episodic memory facilitates flexible decision-making via access to detailed events - Nature Human Behaviour
Nicholas and Mattar found that people use episodic memory to make decisions when it is unclear what will be needed in the future. These findings reveal how the rich representational capacity of episod...
www.nature.com
January 23, 2026 at 1:18 PM
Our experiences have countless details, and it can be hard to know which matter.
How can we behave effectively in the future when, right now, we don't know what we'll need?
Out today in @nathumbehav.nature.com , @marcelomattar.bsky.social and I find that people solve this by using episodic memory.
How can we behave effectively in the future when, right now, we don't know what we'll need?
Out today in @nathumbehav.nature.com , @marcelomattar.bsky.social and I find that people solve this by using episodic memory.
Reposted by Anna Schapiro
We can use past experience to make predictions about the future. How do predictions affect our memory for the present? My own work (tinyurl.com/42kyukch) suggests that predictions compete with memory. But other recent work (tinyurl.com/2ekd4wr6) found the opposite--cooperation! What's going on here?
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
tinyurl.com
January 20, 2026 at 9:45 PM
We can use past experience to make predictions about the future. How do predictions affect our memory for the present? My own work (tinyurl.com/42kyukch) suggests that predictions compete with memory. But other recent work (tinyurl.com/2ekd4wr6) found the opposite--cooperation! What's going on here?
Reposted by Anna Schapiro
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
January 20, 2026 at 10:53 PM
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
Reposted by Anna Schapiro
1. If the goal is to stop us from doing science, then doing science is more important than ever now.
2. We have radical uncertainty about the future. There is no sense in giving up in advance.
3. We have agency over the future. If you don't like what's happening, work to change what is happening.
2. We have radical uncertainty about the future. There is no sense in giving up in advance.
3. We have agency over the future. If you don't like what's happening, work to change what is happening.
Getting asked about how academics can continue to do science & inspire trainees even in the midst of a continued (escalated) assault on science, reason, truth, & human rights. I don’t have great answers.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
January 18, 2026 at 1:24 AM
1. If the goal is to stop us from doing science, then doing science is more important than ever now.
2. We have radical uncertainty about the future. There is no sense in giving up in advance.
3. We have agency over the future. If you don't like what's happening, work to change what is happening.
2. We have radical uncertainty about the future. There is no sense in giving up in advance.
3. We have agency over the future. If you don't like what's happening, work to change what is happening.
Reposted by Anna Schapiro
How do hippocampal pathways contribute to learning regularities and exceptions?
To answer this, Melisa Gumus & @drmack.bsky.social use diffusion imaging to identify the endpoints of different hippocampal pathways, and then analyze functional activity within those "footprints". Super innovative!
To answer this, Melisa Gumus & @drmack.bsky.social use diffusion imaging to identify the endpoints of different hippocampal pathways, and then analyze functional activity within those "footprints". Super innovative!
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 16, 2026 at 6:47 PM
How do hippocampal pathways contribute to learning regularities and exceptions?
To answer this, Melisa Gumus & @drmack.bsky.social use diffusion imaging to identify the endpoints of different hippocampal pathways, and then analyze functional activity within those "footprints". Super innovative!
To answer this, Melisa Gumus & @drmack.bsky.social use diffusion imaging to identify the endpoints of different hippocampal pathways, and then analyze functional activity within those "footprints". Super innovative!
Really thrilled that this paper led by @neurozz.bsky.social is now published in its final version in @elife.bsky.social!!
This is a memory-focused (as opposed to RL-focused) account of the detailed characteristics of forward and backward awake and sleep replay!
elifesciences.org/articles/99931
This is a memory-focused (as opposed to RL-focused) account of the detailed characteristics of forward and backward awake and sleep replay!
elifesciences.org/articles/99931
A unifying account of replay as context-driven memory reactivation
A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing a new account of how and why replay occurs.
elifesciences.org
January 15, 2026 at 1:57 PM
Really thrilled that this paper led by @neurozz.bsky.social is now published in its final version in @elife.bsky.social!!
This is a memory-focused (as opposed to RL-focused) account of the detailed characteristics of forward and backward awake and sleep replay!
elifesciences.org/articles/99931
This is a memory-focused (as opposed to RL-focused) account of the detailed characteristics of forward and backward awake and sleep replay!
elifesciences.org/articles/99931
Reposted by Anna Schapiro
We should no longer trust data collected on MTurk
link.springer.com/article/10.3...
My guess is that other online data is going to drop in quality due to LLMs. This is going to be an existential crisis for the behavioral sciences.
link.springer.com/article/10.3...
My guess is that other online data is going to drop in quality due to LLMs. This is going to be an existential crisis for the behavioral sciences.
January 8, 2026 at 8:26 PM
We should no longer trust data collected on MTurk
link.springer.com/article/10.3...
My guess is that other online data is going to drop in quality due to LLMs. This is going to be an existential crisis for the behavioral sciences.
link.springer.com/article/10.3...
My guess is that other online data is going to drop in quality due to LLMs. This is going to be an existential crisis for the behavioral sciences.
Reposted by Anna Schapiro
🚨 New preprint!
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Neural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentials
Translating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior ...
www.biorxiv.org
January 5, 2026 at 3:21 PM
🚨 New preprint!
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.
www.biorxiv.org/content/10.6...
🧵 (1/10)
🧠🟦 🧠💻
Reposted by Anna Schapiro
Happy New Year everyone!! May your 2026 be blessed with good friends, brave actions, and resilient institutions.
January 1, 2026 at 1:21 PM
Happy New Year everyone!! May your 2026 be blessed with good friends, brave actions, and resilient institutions.
Reposted by Anna Schapiro
We talked about running these numbers at UM soc when it became so obvious that women TAs got more complaints for the same classes. Glad someone tested it formally.
Experimental evidence that students are more likely to contest grades when they are delivered by an evaluator with a female-sounding name.
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
December 25, 2025 at 3:30 PM
We talked about running these numbers at UM soc when it became so obvious that women TAs got more complaints for the same classes. Glad someone tested it formally.
Reposted by Anna Schapiro
Tap tap tap. Does this work? @jenna-m-norton.bsky.social is serves the people. Not the political will. We are #scientists.
#NIHStrong #imwithjenna #BethesdaDeclaration
#NIHStrong #imwithjenna #BethesdaDeclaration
December 17, 2025 at 12:36 AM
Tap tap tap. Does this work? @jenna-m-norton.bsky.social is serves the people. Not the political will. We are #scientists.
#NIHStrong #imwithjenna #BethesdaDeclaration
#NIHStrong #imwithjenna #BethesdaDeclaration
Reposted by Anna Schapiro
The 5th International Sleep Replay Workshop is just 80 days away- Mar 6th in Vancouver!
isrw.bio.uci.edu
If you'd like to be considered to give a short talk, register by December 19th, 2025.
General registration & poster submission ends February 15th, 2026.
@cnsmtg.bsky.social
Please repost
isrw.bio.uci.edu
If you'd like to be considered to give a short talk, register by December 19th, 2025.
General registration & poster submission ends February 15th, 2026.
@cnsmtg.bsky.social
Please repost
International Sleep Replay Workshop – International Sleep Replay Workshop
isrw.bio.uci.edu
December 15, 2025 at 2:39 PM
The 5th International Sleep Replay Workshop is just 80 days away- Mar 6th in Vancouver!
isrw.bio.uci.edu
If you'd like to be considered to give a short talk, register by December 19th, 2025.
General registration & poster submission ends February 15th, 2026.
@cnsmtg.bsky.social
Please repost
isrw.bio.uci.edu
If you'd like to be considered to give a short talk, register by December 19th, 2025.
General registration & poster submission ends February 15th, 2026.
@cnsmtg.bsky.social
Please repost
Reposted by Anna Schapiro
Prediction: task-based optimization will ultimately prove to have a relatively minor role in DNN models of the ventral stream. Although tasks (including self-supervised ones) are currently crucial, there are signs that a simpler approach is possible. A thread:
December 15, 2025 at 6:45 PM
Prediction: task-based optimization will ultimately prove to have a relatively minor role in DNN models of the ventral stream. Although tasks (including self-supervised ones) are currently crucial, there are signs that a simpler approach is possible. A thread:
Reposted by Anna Schapiro
Several people have mentioned online that they get terrible responses from online services such as Prolific, e.g., bots, LLM responses. I'm curious if anyone who has experienced that in a memorable way would mind sharing the details of their project (code, etc.).
December 15, 2025 at 9:30 PM
Several people have mentioned online that they get terrible responses from online services such as Prolific, e.g., bots, LLM responses. I'm curious if anyone who has experienced that in a memorable way would mind sharing the details of their project (code, etc.).
Reposted by Anna Schapiro
Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset size—we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...
December 11, 2025 at 3:32 PM
Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset size—we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...
Proud of the Penn faculty senate for *unanimously* passing this resolution.
December 11, 2025 at 4:22 PM
Proud of the Penn faculty senate for *unanimously* passing this resolution.
Reposted by Anna Schapiro
It's over.
Despite the fact that the academic council recommended against it, despite the fact that the program brought in more tuition than it cost, and despite the fact that Nebraskans need & deserve this expertise, Earth & Atmospheric Sciences will be cut.
www.dailynebraskan.com/news/adminis...
Despite the fact that the academic council recommended against it, despite the fact that the program brought in more tuition than it cost, and despite the fact that Nebraskans need & deserve this expertise, Earth & Atmospheric Sciences will be cut.
www.dailynebraskan.com/news/adminis...
BREAKING: ‘This hurts’: UNL eliminates 4 programs despite faculty, student pleas
The University of Nebraska-Lincoln eliminates the Earth and atmospheric sciences 8-0, educational administration 7-1, statistics 7-1, textiles, merchandising and fashion design 7-1 programs.
www.dailynebraskan.com
December 6, 2025 at 5:35 PM
It's over.
Despite the fact that the academic council recommended against it, despite the fact that the program brought in more tuition than it cost, and despite the fact that Nebraskans need & deserve this expertise, Earth & Atmospheric Sciences will be cut.
www.dailynebraskan.com/news/adminis...
Despite the fact that the academic council recommended against it, despite the fact that the program brought in more tuition than it cost, and despite the fact that Nebraskans need & deserve this expertise, Earth & Atmospheric Sciences will be cut.
www.dailynebraskan.com/news/adminis...
Reposted by Anna Schapiro
Excited to share a new article, led by Barnes Jannuzi. Here we tried to pinpoint something about visual familiarity that isn't reflected in visual cortex via something putatively hippocampal. Nope! Per the theme of this era, the brain is not so simple. /1
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Sharpened visual memory representations are reflected in inferotemporal cortex
Humans and other primates can robustly report whether they've seen specific images before, even when those images are extremely similar to ones they've previously seen. Multiple lines of evidence sugg...
www.jneurosci.org
December 6, 2025 at 4:23 PM
Excited to share a new article, led by Barnes Jannuzi. Here we tried to pinpoint something about visual familiarity that isn't reflected in visual cortex via something putatively hippocampal. Nope! Per the theme of this era, the brain is not so simple. /1
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Reposted by Anna Schapiro
Under Trump, the NIH is giving fewer grants to fewer scientists. The grants awarded are smaller and scientists have less time to spend them.
Projects in cancer, diabetes, aging, neurological disorder, and more are going unfunded.
“Make America Healthy Again.”
Projects in cancer, diabetes, aging, neurological disorder, and more are going unfunded.
“Make America Healthy Again.”
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
A quiet policy change means the government is making fewer bets on long-term science.
www.nytimes.com
December 2, 2025 at 10:01 PM
Under Trump, the NIH is giving fewer grants to fewer scientists. The grants awarded are smaller and scientists have less time to spend them.
Projects in cancer, diabetes, aging, neurological disorder, and more are going unfunded.
“Make America Healthy Again.”
Projects in cancer, diabetes, aging, neurological disorder, and more are going unfunded.
“Make America Healthy Again.”
Reposted by Anna Schapiro
The most frustrating thing about American universities’ fragmented response to the Trump administration (shall each school capitulate with a “deal”?) is that it takes attention and focus away from the broad, destructive cuts to federally funded research that are an ongoing generational disaster.
FYI: law and science, political science, and sociology all still have DDRIG programs run outside of the NSF but funded by NSF. The rest of these programs unfortunately do not.
I run the political science DDRIG.
I run the political science DDRIG.
NEW from me - NSF cancels grant scheme for social science research.
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
November 30, 2025 at 3:34 PM
The most frustrating thing about American universities’ fragmented response to the Trump administration (shall each school capitulate with a “deal”?) is that it takes attention and focus away from the broad, destructive cuts to federally funded research that are an ongoing generational disaster.
I don't think it is physically possible for me to be more excited about this. You want to join this lab, trust me!!
starting fall 2026 i'll be an assistant professor at @upenn.edu 🥳
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
November 26, 2025 at 12:44 PM
I don't think it is physically possible for me to be more excited about this. You want to join this lab, trust me!!
Reposted by Anna Schapiro
starting fall 2026 i'll be an assistant professor at @upenn.edu 🥳
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
November 25, 2025 at 9:36 PM
starting fall 2026 i'll be an assistant professor at @upenn.edu 🥳
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
my lab will develop scalable models/theories of human behavior, focused on memory and perception
currently recruiting PhD students in psychology, neuroscience, & computer science!
reach out if you're interested 😊
Reposted by Anna Schapiro
Forceful op-ed in the Guardian about the UVA and Cornell "deals" with the administration by two lawyers from Penn.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
The University of Virginia and Cornell deals with Trump set a dangerous precedent | Serena Mayeri and Amanda Shanor
The bespoke agreements are full of peril for the universities, allowing the federal government to quietly exert control
www.theguardian.com
November 24, 2025 at 1:29 AM
Forceful op-ed in the Guardian about the UVA and Cornell "deals" with the administration by two lawyers from Penn.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...