📣 New preprint from the Jakobsson lab!

We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Whoop whoop 🥳 it always feels great to celebrate achievements throughout one's scientific journey!

Thanks again to everyone who has been involved, has showed up to cheer with us, and appreciated our latest work on Cell Genomics www.cell.com/cell-genomic...

Excited to share our latest work!! 🌟🌟

Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

I'm so happy and excited to be sharing this!

Feeling deeply grateful for all the collaborative effort that went into the project and very proud of this work.

🧬🧠

I'm so excited and honoured to share our research!! 💡

Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics

Beyond excited to share that I have received a Travel and Merit Award for the ISSCR 2025 Annual Meeting in Hong Kong.

I will present our latest work on the role of LINE-1s in human pluripotency and early brain development (preprint alert: doi.org/10.1101/2025...).

I hope to see you there! 🌺

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.

Check out the full #preprint: shorturl.at/TJ9BK

Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n

www.biorxiv.org/content/10.1...

#TEsky

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾

#TEsky #CRISPR #L1 #development #epigenetics

Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠

Hello bluesky!
Way to kick off 2025! Thanks to everyone involved 🚀

🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps.
@asapresearch.bsky.social @jakobssonlab.bsky.social