ASAP Team Jakobsson
@jakobssonasap.bsky.social
ASAP Team Jakobsson is interested in studying the role of transposable elements in Parkinson's disease pathogenesis | Core leadership: Johan Jakobsson (LU), Agnete Kirkeby (UCPH), Molly Gale Hammell (NYU) & Roger Barker (Cambridge University)
📣 New preprint from the Jakobsson lab!
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
This protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to targ...
www.biorxiv.org
October 29, 2025 at 8:24 AM
📣 New preprint from the Jakobsson lab!
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
October 23, 2025 at 3:04 PM
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
📣 New preprint alert 📣
A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work!
#OpenScience
A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work!
#OpenScience
September 17, 2025 at 7:32 AM
Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1...
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
September 9, 2025 at 9:26 PM
🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1...
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
Reposted by ASAP Team Jakobsson
🧬 🧠A new Cell Genomics study by researchers at @lunduniversity.bsky.social (@jakobssonlab.bsky.social & @jakobssonasap.bsky.social) shows the non-coding genome is active in early brain development & may be relevant for understanding brain disease.
Read more: www.stemcellcenter.lu.se/article/why-...
Read more: www.stemcellcenter.lu.se/article/why-...
Why repetitive DNA matters for human brain evolution and disease
Lund University. DNA carries the complete set of instructions an organism needs to develop and survive, but only about 1.5% of it consists of protein-coding genes that determine traits such as eye col...
www.stemcellcenter.lu.se
August 28, 2025 at 8:45 AM
🧬 🧠A new Cell Genomics study by researchers at @lunduniversity.bsky.social (@jakobssonlab.bsky.social & @jakobssonasap.bsky.social) shows the non-coding genome is active in early brain development & may be relevant for understanding brain disease.
Read more: www.stemcellcenter.lu.se/article/why-...
Read more: www.stemcellcenter.lu.se/article/why-...
Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org
August 27, 2025 at 4:03 PM
Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org
Reposted by ASAP Team Jakobsson
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
July 9, 2025 at 3:20 PM
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
March 18, 2025 at 3:40 PM
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
Reposted by ASAP Team Jakobsson
Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
March 12, 2025 at 9:45 PM
Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
January 20, 2025 at 4:41 PM
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 9:41 AM
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps.
@asapresearch.bsky.social @jakobssonlab.bsky.social
@asapresearch.bsky.social @jakobssonlab.bsky.social
December 10, 2024 at 1:27 PM
🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps.
@asapresearch.bsky.social @jakobssonlab.bsky.social
@asapresearch.bsky.social @jakobssonlab.bsky.social
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...
www.lunduniversity.lu.se/article/52-m...
52 Million SEK towards uncovering genetic drivers of Parkinson’s Disease
Lund University. Jumping genes, or transposable elements, make up nearly half of the human genome. These mobile sequences can shift within the genome and are known to influence various biological proc...
www.lunduniversity.lu.se
December 5, 2024 at 2:45 PM
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...
www.lunduniversity.lu.se/article/52-m...