ASAP CRN Team Cragg
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craggasap.bsky.social
ASAP CRN Team Cragg
@craggasap.bsky.social
ASAP CRN Team Cragg interested in DA & ACh neuromodulation in PD.

Steph Cragg, Richard Wade-Martins, Peter Magill @University of Oxford
Dinos Meletis @Karolinska Institutet
Mark Howe @Boston University

Managed by Cláudia Mendes & Alicia Twisselmann.
It is with deep sadness that we share the passing of Dr. Richard Exley.

Richard was Steph Cragg's first postdoc, who is remembered as a brilliant scientist and a joyful colleague. Our thoughts are with his family and loved ones at this difficult time, and may his memory continue to inspire us all.
November 14, 2025 at 2:51 PM
Welcome to the team, Mara Wuelfing!

Mara is completing her Biochemistry Part II Project in the Cragg Lab, where she will be investigating the source of tonic adenosine in the nucleus accumbens under the supervision of Kat Todd, an ASAP-funded postdoc.

#MeetOurTeam
November 14, 2025 at 2:20 PM
Welcome to the team, Katherine Wang and Isabella Wijsmann!

Katherine joins as an MRC-funded Research Assistant and Isabella as a DPhil student at Cragg Lab, where they will be working on how novel glycine receptors shape #dopamine and #acetylcholine signalling in health and #PD.

#MeetOurTeam
November 14, 2025 at 1:53 PM
🎉Congratulations Dr. Qinbo Qiao of the Cragg lab! 🎉

Your hard work has paid off, and Team Cragg is so proud of you. We can't wait to see where life takes you, and good luck at your new position in Shanghai!

@stephcragg.bsky.social @oxforddpag.bsky.social
October 23, 2025 at 1:40 PM
We were thrilled to (mostly) meet in-person last week for the 3rd Annual Symposium of ASAP Collaboration for Team Cragg!

Thank you all for an inspiring meeting of science, sharing and #collaboration. We have built a great momentum, and we are ready for new discoveries in #Parkinsons research!
October 23, 2025 at 1:30 PM
📣 New preprint alert 📣

A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work!

#OpenScience
September 11, 2025 at 9:04 PM
Meet Tony Barbay, our new MRC-funded Postdoctoral Researcher at Cragg Lab! He will explore the role of astrocytes as neuromodulators in the striatum in health and PD. We look forward to working with you!

Learn more: www.dpag.ox.ac.uk/team/tony-ba...

#Parkinsons #astrocytes #The_MRC #MeetOurTeam
Tony Barbay
PhD Tony Barbay - Postdoctoral Research Scientist
www.dpag.ox.ac.uk
September 4, 2025 at 11:24 AM
📣The Wade-Martins Lab is hiring 📣

Are you interested in developing novel biomarkers and testing therapeutic compounds using iPSC-derived dopamine neurons from PD patients? Join us as a Research Assistant at the University of Oxford.

Deadline is noon (UK time) on Sept 5th!

bit.ly/4lURYW9
August 29, 2025 at 12:19 PM
Reposted by ASAP CRN Team Cragg
We're kicking off our new series: Initiative Spotlight 🔦 starting with Aligning Science Across Parkinson's (ASAP)!

@asapresearch.parkinsonsroadmap.org aims to speed discovery and drive progress toward a #ParkinsonsDisease cure through collaboration and open science.

Learn more: bit.ly/3Ys7sIo
August 7, 2025 at 3:40 PM
In case you missed it, be sure to watch July's instalment of the Discover ASAP!

Ricardo Márquez Gómez from Wade-Martins Lab discussed their scalable microfluidic platform that enables the study of human neuron microcircuitry, connectivity, and regeneration in vitro 🔬

#OpenScience #PD #iPSCs
This month’s Discover ASAP features Ricardo Márquez Gómez of @craggasap.bsky.social, discussing a fluid-wall microfluidic platform to model human corticostriatal circuits 🧪

This platform enables axon studies, long-term culture, & scalable testing for #Parkinsons.

📺 youtu.be/dutY_mxext4
August 29, 2025 at 12:01 PM
Fantastic work spearheaded by @safabouabid.bsky.social from Mark Howe Lab!
CRN Team Cragg used array photometry in mice to reveal a topography of opposing changes in ACh release across distinct striatal regions. Reward prediction error encoding was localized to specific phases of ACh dynamics in anterior dorsal striatum.

🔗 Read the full #publication: bit.ly/3JjqQCE
August 27, 2025 at 10:32 AM
Check out Katherine Brimblecombe's news article on outreach activities!

Katherine reflects on how her outreach work with primary school kids has led to changes in the way she thinks about science communication.

#SciComm #ScienceOutreach #WomenInSTEM #STEM
Outreach: How Science Week's 2025 theme made me reflect on how I talk about science (by Dr Katherine Brimblecombe)
Science week 2025 theme: Change and adapt
www.dpag.ox.ac.uk
August 27, 2025 at 10:26 AM
📣 New publication alert 📣

Check out our collaborative review on axonal molecular and circuit mechanisms governing dopamine exocytosis in health and PD. Congratulations to Kathryn Todd from Cragg Lab and Kaitlyn Cramb from Wade-Martins Lab for spearheading this publication!
New insights into axonal regulators of dopamine transmission in health and disease
Dopamine release in the striatum is credited with being critical to the selection and learning of motivated actions and outcomes. Dysregulation of str…
www.sciencedirect.com
August 22, 2025 at 4:33 AM
Are you at the ISN-ASN Meeting held in New York this week?

Don't miss out the talk from our very own Steph Cragg this Friday from 3 to 5 pm EDT! The "Flowing Neurochemicals in the Brain" symposium is being chaired by CRN members Yulong Li and Lin Tian.
S27 T#2 Flowing Neurochemicals in the Brain - ISN
Room: Hall C – Parallel 2 Chair: Yulong Li (China) Lin Tian (United States) Designs, applications and limitations of genetically encoded indicators in imaging neurotransmitters in vivo Stephanie Cragg...
www.neurochemistry.org
August 22, 2025 at 4:11 AM
📣 A new book announcement 📣

The Handbook of #dopamine, from Steph Cragg (@stephcragg.bsky.social) and Mark Walton, and a cover illustration from the talented Lucille Duquenoy from Cragg Lab, is available to pre-order now!
August 19, 2025 at 3:39 PM
Congratulations to Shinil Raina, who left her position as a RA in the Cragg Lab to take up an MRC iCase funded DPhil position in the Yeo lab at University of Cambridge. We will miss you dearly and wish you the best of luck on your endeavours!

Who will win the best poster awards for our team now?
August 19, 2025 at 3:30 PM
A new #MRC CoRE will focus on developing brain stimulation devices to treat conditions such as Parkinson’s, dementia, stroke and childhood epilepsy.

🎉Many congratulations to our co-PI, Professor Peter Magill, who will be the Director of the MRC CoRE in Restorative Neural Dynamics! 🎉
Oxford to lead new £50m MRC Centre to develop brain stimulation
A new Medical Research Council Centre of Research Excellence (MRC CoRE) aims to develop brain stimulation devices to treat conditions such as Parkinson’s, dementia, stroke and childhood epilepsy.
www.ox.ac.uk
July 7, 2025 at 10:17 AM
Team Cragg was out in full-force at the 2025 Oxford Parkinson's Research Day hosted by OPDC earlier this month!

📣 Shoutout to our presenters, Kaitlyn Cramb, Katherine Brimblecombe, Ollie Curry, Rasha Elghaba, and Camille Loiseau, for sharing their fantastic work with the PD community! 📣
June 30, 2025 at 3:07 PM
Congratulations to our Project Manager Cláudia Mendes for being nominated as ASAP #OpenScience Champion this month!

Claudia is deeply committed to make science more open and transparent at all stages of scientific discovery. Thank you for her hard work for making our articles fully ASAP-compliant!
🎊 This month, we are celebrating Claudia Mendes from @craggasap.bsky.social and Julianna Tomlinson from CRN Team Schlossmacher as our June #OpenScience Champions for user testing the new Hub Compliance Submission System and providing feedback. Thank you both for your dedication to open science.
June 30, 2025 at 3:00 PM
A new publication from Howe Lab is out in Nature Comms examining how #acetylcholine dynamics shape region-specific plasticity to gate learning and promote extinction. Congrats to Safa, Mai-Anh, and the rest of the authors for a fantastic #openscience paper!

@asapresearch.parkinsonsroadmap.org
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations - Nature Communications
Functional roles of natural acetylcholine (ACh) dynamics are not fully understood. This study reveals dynamic changes in ACh release across the mouse striatum during learning and extinction, identifyi...
doi.org
June 23, 2025 at 2:50 PM
🎉Many congratulations to Dr. Bethan O'Connor, and Dr. Lucille Duquenoy from the Cragg Lab who recently passed their DPhil Vivas 🎉

Your hard work and effort has paid off, and Team Cragg is proud of all you have accomplished!

@stephcragg.bsky.social @oxforddpag.bsky.social
June 12, 2025 at 11:44 PM
The Cragg lab is going to NeuroFrance 2025 in Montpellier!

Our very own PI Steph Cragg will give a plenary lecture on astrocytes, dopamine and acetylcholine, and lab members Simon Bossi and Lucille Duquenoy will present posters on their impressive work. Come say hi!

www.neurosciences.asso.fr/SN25/
Home - NeuroFrance 2025
Every two years, neuroscientists from all over France get together to share their research, discover new ideas and exchange views and opinions.
www.neurosciences.asso.fr
May 8, 2025 at 11:24 AM
Congratulations to Katherine Brimblecombe from Cragg Lab!

Her study on L-type calcium channels and striatal dopamine release (doi.org/10.1111/ejn....) is among the most widely read papers published by EJN in 2023!

A fantastic recognition of her work within the community!

@stephcragg.bsky.social
May 8, 2025 at 11:00 AM
Reposted by ASAP CRN Team Cragg
🧠 Today on #WorldParkinsonsDay, we honor those living with Parkinson’s and the scientists advancing our understanding of #neurodegeneration, from alpha-synuclein to inflammation. Every insight brings us closer to breakthroughs.
April 11, 2025 at 3:57 PM
🎉 The Cragg lab is hiring 🎉 Are you interest in striatal neurobiology and have relevant lab experience? Join us as an MRC-funded Research Assistant at the University of Oxford. Deadline is noon (UK time) on May 2nd.

@stephcragg.bsky.social @oxforddpag.bsky.social

my.corehr.com/pls/uoxrecru...
April 19, 2025 at 11:32 AM