Andy Truman
@andytruman4.bsky.social
Group Leader at the John Innes Centre. Biosynthesis and discovery of specialised metabolites. Norwich. He/Him.
https://www.jic.ac.uk/people/andrew-truman/
https://www.jic.ac.uk/people/andrew-truman/
Pinned
Andy Truman
@andytruman4.bsky.social
· May 20
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
Reposted by Andy Truman
People are starving to death, or being gunned down while desperately trying to access food at aid sites — even journalists are in grave danger. This abhorrent situation cannot be allowed to continue
www.bbc.co.uk/news/live/cv...
www.bbc.co.uk/news/live/cv...
Gaza health ministry says 33 people dead from malnutrition in last 48 hours
New figures from the Hamas-run ministry include 12 children who have died, as the UN says Israel must allow aid into Gaza.
www.bbc.co.uk
July 22, 2025 at 2:26 PM
People are starving to death, or being gunned down while desperately trying to access food at aid sites — even journalists are in grave danger. This abhorrent situation cannot be allowed to continue
www.bbc.co.uk/news/live/cv...
www.bbc.co.uk/news/live/cv...
Reposted by Andy Truman
Thanks for your advocacy and this excellent letter, @anthrofuentes.bsky.social !
This is not the time to step back from diversity, equity, and inclusion
Recently, I exchanged views with a prominent Ivy League scientist who was complaining about the minority students and junior faculty applying to his program. He claimed that the university, through di...
www.science.org
July 18, 2025 at 2:02 PM
Thanks for your advocacy and this excellent letter, @anthrofuentes.bsky.social !
Cycling achievement unlocked: Strava “excluding” my ride as its rubbish AI can’t believe I could ride this fast 😂
July 12, 2025 at 12:38 PM
Cycling achievement unlocked: Strava “excluding” my ride as its rubbish AI can’t believe I could ride this fast 😂
It always pleases me to see how little we know. I can pick a random ~700 AA protein from a bacterial genome and it has no conserved domains and no characterised structural homologues, yet there are >1000 homologues across diverse Gram+ and Gram- bacteria.
July 9, 2025 at 2:34 PM
It always pleases me to see how little we know. I can pick a random ~700 AA protein from a bacterial genome and it has no conserved domains and no characterised structural homologues, yet there are >1000 homologues across diverse Gram+ and Gram- bacteria.
Reposted by Andy Truman
Hungary banned Pride marches. This is the response ✊🏳️🌈
Absolutely incredible turnout for Budapest Pride! So proud of all the organizers, including some old friends, who estimate hundreds of thousands— major embarrassment to Orban
June 28, 2025 at 10:54 PM
Hungary banned Pride marches. This is the response ✊🏳️🌈
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
May 20, 2025 at 10:40 AM
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
www.pnas.org/doi/10.1073/...
The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic.
@johninnescentre.bsky.social
Returning home after a fun couple of days in London at the RSC Chemical Biology Symposium and then the Chemical Biology Interface Council meeting. Excellent talks and always a joy to return to Burlington House @rsc.org
May 13, 2025 at 5:13 PM
Returning home after a fun couple of days in London at the RSC Chemical Biology Symposium and then the Chemical Biology Interface Council meeting. Excellent talks and always a joy to return to Burlington House @rsc.org
Happy Tuesday to everyone apart from whoever approved this awful design! Annoys me every time I use Greater Anglia.
May 13, 2025 at 5:08 PM
Happy Tuesday to everyone apart from whoever approved this awful design! Annoys me every time I use Greater Anglia.
Join us for the RSC Chemical Biology Leadership Retreat for Early Career Researchers! This is designed for researchers within 5 years of their first independent position. Bursuries are available (details in link below).
Venue: Imperial College London
Date: 10-12 Sep 2025
www.rsc.org/events/detai...
Venue: Imperial College London
Date: 10-12 Sep 2025
www.rsc.org/events/detai...
2nd CBIC Chemical Biology Leadership Retreat for Early Career Researchers
www.rsc.org
April 14, 2025 at 11:04 AM
Join us for the RSC Chemical Biology Leadership Retreat for Early Career Researchers! This is designed for researchers within 5 years of their first independent position. Bursuries are available (details in link below).
Venue: Imperial College London
Date: 10-12 Sep 2025
www.rsc.org/events/detai...
Venue: Imperial College London
Date: 10-12 Sep 2025
www.rsc.org/events/detai...
Reposted by Andy Truman
We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long!
www.jic.ac.uk/vacancies/po...
www.jic.ac.uk/vacancies/po...
Postdoctoral Researcher (Faulkner Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell & Developmental Biology.
www.jic.ac.uk
March 11, 2025 at 11:57 AM
We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long!
www.jic.ac.uk/vacancies/po...
www.jic.ac.uk/vacancies/po...
Reposted by Andy Truman
If you have a few minutes spare in your busy schedule today, it's well worth taking time to read this article from @lewisgoodall.com.
Trump could have pushed for an end to the war in Ukraine without becoming actively hostile to Ukraine. Instead, he has imbibed Putin’s lies. Have written about the emergence of a new US/Russia axis, where it comes from and the staggering implications for Europe.
open.substack.com/pub/goodalla...
open.substack.com/pub/goodalla...
We're waking up to a new US/Russia axis
Why Trump clings to Putin.
open.substack.com
February 20, 2025 at 9:05 AM
If you have a few minutes spare in your busy schedule today, it's well worth taking time to read this article from @lewisgoodall.com.
Reposted by Andy Truman
PRESS RELEASE - Professor Uauy appointed as Director of the John Innes Centre
Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre.
www.jic.ac.uk/press-releas...
@ukri.org
Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre.
www.jic.ac.uk/press-releas...
@ukri.org
Professor Uauy appointed as Director of the John Innes Centre | John Innes Centre
Following an international search, Professor Cristóbal Uauy has been appointed as the next Director of the John Innes Centre. Professor Uauy is internationally recognised for his significant…
www.jic.ac.uk
February 13, 2025 at 12:34 AM
PRESS RELEASE - Professor Uauy appointed as Director of the John Innes Centre
Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre.
www.jic.ac.uk/press-releas...
@ukri.org
Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre.
www.jic.ac.uk/press-releas...
@ukri.org
Utterly bonkers. I’m stating the very obvious, but it’s remarkable (yet also depressingly predictable) how quickly the proponents of “free speech” start banning everything they don’t like.
We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.
February 11, 2025 at 2:49 PM
Utterly bonkers. I’m stating the very obvious, but it’s remarkable (yet also depressingly predictable) how quickly the proponents of “free speech” start banning everything they don’t like.
We have an exciting full-time permanent position available for a proteomics specialist for the Proteomics platform at @johninnescentre.bsky.social The platform has excellent facilities and provides essential experimental expertise research at the institute.
jobs.jic.ac.uk/Details.asp?...
jobs.jic.ac.uk/Details.asp?...
John Innes Centre
jobs.jic.ac.uk
February 11, 2025 at 10:22 AM
We have an exciting full-time permanent position available for a proteomics specialist for the Proteomics platform at @johninnescentre.bsky.social The platform has excellent facilities and provides essential experimental expertise research at the institute.
jobs.jic.ac.uk/Details.asp?...
jobs.jic.ac.uk/Details.asp?...
#NowListening some banging tunes on.soundcloud.com/ZbMUDa61xrHo...
Anish Kumar - BBCR1 Essential Mix [02.11.24]
Tracklist
01 Anish Kumar - ID1 [unreleased]
02 DWIG - Luise und die Strandpiraten [Giegling]
03 Anish Kumar - ID2 [unreleased]
04 The Blessed Madonna - Exodus [Stripped & Chewed]
05 K-Lone - Cinco [Sw
on.soundcloud.com
February 9, 2025 at 9:31 PM
#NowListening some banging tunes on.soundcloud.com/ZbMUDa61xrHo...
Harmless Scientific Experiments for Boys (the introduction does at least acknowledge that girls can also use the book) including such “harmless” experiments as making gas from coal, and a DIY thermometer involving your own glass blowing and “a very small quantity of mercury” 🤔
February 7, 2025 at 1:21 PM
Harmless Scientific Experiments for Boys (the introduction does at least acknowledge that girls can also use the book) including such “harmless” experiments as making gas from coal, and a DIY thermometer involving your own glass blowing and “a very small quantity of mercury” 🤔
Reposted by Andy Truman
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
February 3, 2025 at 4:39 AM
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
Is anyone having issues with NCBI at the moment? Really difficult to reliably retrieve sequence data using Entrez. Unsure if this is an impact of the absurd presidential decisions about the NIH, or just routine maintenance?
January 28, 2025 at 3:28 PM
Is anyone having issues with NCBI at the moment? Really difficult to reliably retrieve sequence data using Entrez. Unsure if this is an impact of the absurd presidential decisions about the NIH, or just routine maintenance?
Reposted by Andy Truman
This is how Bruce Wayne became a millionaire
Includes the astonishing stat that HS2 paid £330,000 per inconvenienced bat.
January 9, 2025 at 11:00 AM
This is how Bruce Wayne became a millionaire
Reposted by Andy Truman
Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now @cellhostmicrobe It’s just in time for the holidays 🎄🦠 www.cell.com/cell-host-mi...
A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants
Grenz et al. interrogate the Pseudomonas syringae species complex for its capacity to infect evolutionarily divergent host plants. Their results demonstrate that broad host isolates from phylogroup 2 rely on the lipopeptide toxin syringomycin to promote host necrosis and enhance bacterial growth in plants.
www.cell.com
December 19, 2024 at 4:10 PM
Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now @cellhostmicrobe It’s just in time for the holidays 🎄🦠 www.cell.com/cell-host-mi...
Returning to the UK after a great trip to beautiful Gent. Alway a pleasure to hear about the natural products research happening there 😊 Also got to dress up in a gown for the first time in years! Now to the JIC Mol Micro Xmas lunch to “recover” after last night’s Belgian beers 😂
December 13, 2024 at 9:41 AM
Returning to the UK after a great trip to beautiful Gent. Alway a pleasure to hear about the natural products research happening there 😊 Also got to dress up in a gown for the first time in years! Now to the JIC Mol Micro Xmas lunch to “recover” after last night’s Belgian beers 😂
Reposted by Andy Truman
Taking Britain out of the Erasmus+ programme was a huge mistake. Labour must rejoin and accept the EU’s offer of a youth mobility scheme
Bring back Erasmus+ and youth mobility in Europe
Taking Britain out of the Erasmus+ programme was a huge mistake. Labour must rejoin and accept the EU’s offer of a youth mobility scheme
sussexbylines.co.uk
December 12, 2024 at 9:25 AM
Taking Britain out of the Erasmus+ programme was a huge mistake. Labour must rejoin and accept the EU’s offer of a youth mobility scheme
Reposted by Andy Truman
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
academic.oup.com
December 10, 2024 at 8:05 AM
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
Reposted by Andy Truman
We find a lot of proteins - particularly antibiotic biosynthetic enzymes - are produced in soluble form in Streptomyces lividans but not E.coli. It’s a useful platform for the production of otherwise intractable proteins.
pIJ86 sequence and map just added to actinobase.org. Useful for anyone wanting to over produce proteins in Streptomyces species. Plasmid available free from JIC (streptomyces.org.uk)
ActinoBase
actinobase.org
November 29, 2024 at 4:02 PM
We find a lot of proteins - particularly antibiotic biosynthetic enzymes - are produced in soluble form in Streptomyces lividans but not E.coli. It’s a useful platform for the production of otherwise intractable proteins.
Reposted by Andy Truman
The Natural Products Atlas 3.0: extending the database of microbially derived natural products - thanks to the Linington lab for letting the Duncan lab be part of the curation efforts academic.oup.com/nar/advance-... #NaturalProducts #SpecializedMetabolites #microsky #microbialchemistry
The Natural Products Atlas 3.0: extending the database of microbially derived natural products
Abstract. The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthe
academic.oup.com
November 26, 2024 at 5:13 PM
The Natural Products Atlas 3.0: extending the database of microbially derived natural products - thanks to the Linington lab for letting the Duncan lab be part of the curation efforts academic.oup.com/nar/advance-... #NaturalProducts #SpecializedMetabolites #microsky #microbialchemistry