Andrea Cosentino
@andreacsn.bsky.social
MD Hematologist - Here to be inspired
Reposted by Andrea Cosentino
CAR T cells in the bone marrow maintain an activation state that results in inflammation that leads to hypoplasia 🇨🇵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CAR T cell–mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis
CAR T cells are found in the bone marrow (BM), where they maintain an activation state that results in inflammation that leads to BM hypoplasia.
www.science.org
September 24, 2025 at 7:52 PM
CAR T cells in the bone marrow maintain an activation state that results in inflammation that leads to hypoplasia 🇨🇵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Andrea Cosentino
Reposted by Andrea Cosentino
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Andrea Cosentino
Considering how expensive radiocesium is, it is indeed a Great Value to sell it for the price of shrimp.
August 19, 2025 at 8:00 PM
Considering how expensive radiocesium is, it is indeed a Great Value to sell it for the price of shrimp.
Reposted by Andrea Cosentino
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled
to mitochondria, leading to programmed cell death independently of the loss of RNA
Pol II transcription activity...
www.cell.com
August 15, 2025 at 6:35 PM
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
Reposted by Andrea Cosentino
Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1
August 10, 2025 at 8:33 AM
Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1
Reposted by Andrea Cosentino
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
July 22, 2025 at 9:59 PM
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Reposted by Andrea Cosentino
Reposted by Andrea Cosentino
Environmental stress drives clearance of a persistent enteric virus in mice @natmicrobiol.nature.com @cadwelllab.bsky.social www.nature.com/articles/s41...
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
www.nature.com
June 25, 2025 at 4:49 PM
Environmental stress drives clearance of a persistent enteric virus in mice @natmicrobiol.nature.com @cadwelllab.bsky.social www.nature.com/articles/s41...
Reposted by Andrea Cosentino
Pan-viral ORFs discovery using massively parallel ribosome profiling @science.org @shiraweingarten.bsky.social @sabetilab.bsky.social @pardissabeti.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 13, 2025 at 4:09 AM
Pan-viral ORFs discovery using massively parallel ribosome profiling @science.org @shiraweingarten.bsky.social @sabetilab.bsky.social @pardissabeti.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Andrea Cosentino
@cellcellpress.bsky.social preview:
Reaching for more: How reproduction transforms the maternal intestine
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reaching for more: How reproduction transforms the maternal intestine
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
May 16, 2025 at 1:45 AM
@cellcellpress.bsky.social preview:
Reaching for more: How reproduction transforms the maternal intestine
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reaching for more: How reproduction transforms the maternal intestine
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Andrea Cosentino
Taurine from tumor niche drives glycolysis to promote leukeamogenesis @nature.com @jeevishabajaj.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 14, 2025 at 5:14 PM
Taurine from tumor niche drives glycolysis to promote leukeamogenesis @nature.com @jeevishabajaj.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is so cool!
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 3:29 PM
This is so cool!
Reposted by Andrea Cosentino
Why test #celltherapies one-by-one when you can use multiplexed #SynBio #proteinengineering & #ML to design, measure & track them at scale?
The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!
More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏
The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!
More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏
April 29, 2025 at 11:01 PM
Why test #celltherapies one-by-one when you can use multiplexed #SynBio #proteinengineering & #ML to design, measure & track them at scale?
The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!
More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏
The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!
More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏
Reposted by Andrea Cosentino
Reprogramming site-specific retrotransposon activity to new DNA sites @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:41 PM
Reprogramming site-specific retrotransposon activity to new DNA sites @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrea Cosentino
DNA-guided transcription factor interactions extend human gene regulatory code @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:47 PM
DNA-guided transcription factor interactions extend human gene regulatory code @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The joy of learning:
"In the early 1980s, it was discovered that 1 mutation in the fruit fly genome could specifically activate all copies of a retrovirus-like element called Gypsy in the female germline. The site of the mutations that made these Gypsies "dance" was thus called the flamenco locus."
"In the early 1980s, it was discovered that 1 mutation in the fruit fly genome could specifically activate all copies of a retrovirus-like element called Gypsy in the female germline. The site of the mutations that made these Gypsies "dance" was thus called the flamenco locus."
Piwi-interacting RNA - Wikipedia
en.wikipedia.org
April 8, 2025 at 2:28 AM
The joy of learning:
"In the early 1980s, it was discovered that 1 mutation in the fruit fly genome could specifically activate all copies of a retrovirus-like element called Gypsy in the female germline. The site of the mutations that made these Gypsies "dance" was thus called the flamenco locus."
"In the early 1980s, it was discovered that 1 mutation in the fruit fly genome could specifically activate all copies of a retrovirus-like element called Gypsy in the female germline. The site of the mutations that made these Gypsies "dance" was thus called the flamenco locus."
Reposted by Andrea Cosentino
Scalable and cost-efficient custom gene library assembly from oligopools https://www.biorxiv.org/content/10.1101/2025.03.22.644747v1
March 23, 2025 at 5:03 AM
Scalable and cost-efficient custom gene library assembly from oligopools https://www.biorxiv.org/content/10.1101/2025.03.22.644747v1
Reposted by Andrea Cosentino
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
March 10, 2025 at 4:32 PM
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
Reposted by Andrea Cosentino
Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature
Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...
www.nature.com
March 11, 2025 at 11:22 PM
Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrea Cosentino
Congrats @automnenine.bsky.social and @kellythd-nguyen.bsky.social !
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural mechanism of LINE-1 target-primed reverse transcription
Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...
www.science.org
March 6, 2025 at 7:37 PM
Reposted by Andrea Cosentino
Vitamin C directly modifies lysine residues through vitcylation, regulating STAT1 signaling and enhancing anti-tumor immune responses by preventing STAT1 dephosphorylation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
February 28, 2025 at 5:21 PM
Vitamin C directly modifies lysine residues through vitcylation, regulating STAT1 signaling and enhancing anti-tumor immune responses by preventing STAT1 dephosphorylation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Andrea Cosentino
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
www.nature.com
February 28, 2025 at 3:50 PM
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Studying outliers is always super interesting! What a fascinating combination of genetic variants, epigenetic phenotypes, microbiome compositions... I would also really love to hear the story of her life. Amazing work!
The Multiomics Blueprint of Extreme Human Lifespan https://www.biorxiv.org/content/10.1101/2025.02.24.639740v1
February 25, 2025 at 4:18 PM
Studying outliers is always super interesting! What a fascinating combination of genetic variants, epigenetic phenotypes, microbiome compositions... I would also really love to hear the story of her life. Amazing work!
Reposted by Andrea Cosentino
The Multiomics Blueprint of Extreme Human Lifespan https://www.biorxiv.org/content/10.1101/2025.02.24.639740v1
February 25, 2025 at 3:38 PM
The Multiomics Blueprint of Extreme Human Lifespan https://www.biorxiv.org/content/10.1101/2025.02.24.639740v1