Reposted by Amy McCart Reed
Exciting update to our #lobular breast cancer work with DNA repair and PARP inhibition, ahead of @sabcs.bsky.social next week! #oncosky #bcsm
www.biorxiv.org/content/10.1...
Despite lacking "BRCA-like" mutations and features, we find ILC models are sensitive to PARPi in vivo. Why? 🧵 1/n
www.biorxiv.org/content/10.1...
Despite lacking "BRCA-like" mutations and features, we find ILC models are sensitive to PARPi in vivo. Why? 🧵 1/n
Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast
Invasive lobular carcinoma of the breast (ILC) are typically estrogen receptor α (ER)-positive and present with biomarkers of anti-estrogen sensitive disease, yet patients with ILC face uniquely poor ...
www.biorxiv.org
December 6, 2024 at 9:47 PM
Exciting update to our #lobular breast cancer work with DNA repair and PARP inhibition, ahead of @sabcs.bsky.social next week! #oncosky #bcsm
www.biorxiv.org/content/10.1...
Despite lacking "BRCA-like" mutations and features, we find ILC models are sensitive to PARPi in vivo. Why? 🧵 1/n
www.biorxiv.org/content/10.1...
Despite lacking "BRCA-like" mutations and features, we find ILC models are sensitive to PARPi in vivo. Why? 🧵 1/n
Dharmesh maybe not loving the spotlight (in his eyes) 🔦🔦🔦🤣🤣🤣 #SpaNorm #multiomics2024 @bhuvad.bsky.social
December 3, 2024 at 1:13 AM
Dharmesh maybe not loving the spotlight (in his eyes) 🔦🔦🔦🤣🤣🤣 #SpaNorm #multiomics2024 @bhuvad.bsky.social
Watching @anandpatellab.bsky.social give a masterclass in collaboration for #multiomic analysis of #neuroblastoma #multiomics2024
December 2, 2024 at 10:59 PM
Watching @anandpatellab.bsky.social give a masterclass in collaboration for #multiomic analysis of #neuroblastoma #multiomics2024
#uqccr #uq represent! Prof Salomon wowing the crowd again #multiomics2024 #evs#extracellularvesicles #ovariancancer
December 2, 2024 at 1:49 AM
#uqccr #uq represent! Prof Salomon wowing the crowd again #multiomics2024 #evs#extracellularvesicles #ovariancancer
Reposted by Amy McCart Reed
Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
December 2, 2024 at 1:10 AM
Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
Amazing end to Day1 of #multiomics2024 Already excited for tomorrow’s talks #brisbane #breastcancer #metaplastic
December 1, 2024 at 8:40 AM
Amazing end to Day1 of #multiomics2024 Already excited for tomorrow’s talks #brisbane #breastcancer #metaplastic
Reposted by Amy McCart Reed
When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳
December 1, 2024 at 6:29 AM
When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳
Reposted by Amy McCart Reed
An analogy of the differences between bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics
#multiomics2024 10/
#multiomics2024 10/
December 1, 2024 at 2:20 AM
An analogy of the differences between bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics
#multiomics2024 10/
#multiomics2024 10/
Reposted by Amy McCart Reed
It is not enough to study cancer cells in isolation. Tumors are an ecosystem of interacting & inter-dependent cellular communities: "seed vs soil."
#multiomics2024 5/
#multiomics2024 5/
December 1, 2024 at 5:02 AM
It is not enough to study cancer cells in isolation. Tumors are an ecosystem of interacting & inter-dependent cellular communities: "seed vs soil."
#multiomics2024 5/
#multiomics2024 5/
Forget livetweeting we are now live illustrating!!!! #headandneck #multiomics2024
December 1, 2024 at 5:25 AM
Forget livetweeting we are now live illustrating!!!! #headandneck #multiomics2024
Kicking off #multiomics2024 in style here in Brisbane. So sorry about the humidity everyone!!!
November 30, 2024 at 11:45 PM
Kicking off #multiomics2024 in style here in Brisbane. So sorry about the humidity everyone!!!
Reposted by Amy McCart Reed
If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs
November 26, 2024 at 1:46 AM
If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs