Amy McCart Reed
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amymccart.bsky.social
Amy McCart Reed
@amymccart.bsky.social
130 followers 380 following 8 posts
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amymccart.bsky.social
Amazing stuff Matt and team #lobular👏👏👏
December 7, 2024 at 7:46 AM
amymccart.bsky.social
December 2, 2024 at 1:50 AM
Reposted by Amy McCart Reed
math-rachel.bsky.social
An analogy of the differences between bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics

#multiomics2024 10/
bulk RNA-seq: a big pile of different colored legs all mixed up single-cell RNA-seq: small piles of Legos organized by color spatial transcriptomics: image of the brain built out of Legos
December 1, 2024 at 2:20 AM
Reposted by Amy McCart Reed
math-rachel.bsky.social
It is not enough to study cancer cells in isolation. Tumors are an ecosystem of interacting & inter-dependent cellular communities: "seed vs soil."

#multiomics2024 5/
Tumors: an ecosystem of interacting and inter-dependent cellular communities: "seed vs soil" Define complexity of the TME @single cell-spatial resolution Composition (identities) Lineage and dynamics Gene regulatory networks (GRNS) Specialized functions Cell-cell interactions (tumor-stroma-immune) Investigate mechanisms of cross-regulatory interactions drive cancer cell plasticity define intra-tumor phenotypic heterogeneity modulate therapy response
December 1, 2024 at 5:02 AM