Allard van Renterghem
@allardvanr.bsky.social
MD | PhD candidate at the Netherlands Cancer Institute
Precision Immuno-oncology | Tissue residency | Metastases | DE&I advocate in academia and clinic
Precision Immuno-oncology | Tissue residency | Metastases | DE&I advocate in academia and clinic
Pinned
Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer
van Renterghem et al. investigate the impact of liver metastases on immunity in MMR-d/MSI-hi
patients treated with ICB. They show that IL18 activates liver-derived Vδ1+ T cells
and predicts ICB benefi...
www.cell.com
Why do patients with liver metastases respond so poorly to cancer immunotherapy?
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Why do patients with liver metastases respond so poorly to cancer immunotherapy?
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer
van Renterghem et al. investigate the impact of liver metastases on immunity in MMR-d/MSI-hi
patients treated with ICB. They show that IL18 activates liver-derived Vδ1+ T cells
and predicts ICB benefi...
www.cell.com
January 27, 2026 at 2:29 PM
Why do patients with liver metastases respond so poorly to cancer immunotherapy?
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Here we find a new immunological mechanism in MMR-d cancers centering on IL-18 and γδ T cells.👇 www.cell.com/cell-reports... @cp-cellrepmed.bsky.social
Reposted by Allard van Renterghem
Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 26, 2026 at 8:27 PM
Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Taking over the hospital for prideweek with gendercupcakes
@nkinl.bsky.social @florencevb.bsky.social #diversity
@nkinl.bsky.social @florencevb.bsky.social #diversity
July 29, 2025 at 12:26 PM
Taking over the hospital for prideweek with gendercupcakes
@nkinl.bsky.social @florencevb.bsky.social #diversity
@nkinl.bsky.social @florencevb.bsky.social #diversity
Reposted by Allard van Renterghem
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread
Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…
www.sciencedirect.com
May 8, 2025 at 4:44 PM
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Allard van Renterghem
Nature research paper: Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
https://go.nature.com/4jonL1b
https://go.nature.com/4jonL1b
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer - Nature
Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.
go.nature.com
April 25, 2025 at 7:48 AM
Nature research paper: Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
https://go.nature.com/4jonL1b
https://go.nature.com/4jonL1b
While diversity initiatives are under attack, at the netherlands cancer institute (@nkinl.bsky.social) we firmly believe in creating an inclusive & diverse environment! Together with Humanity in Action we hosted a workshop about recognizing and prevent discrimination in healthcare & academia
March 25, 2025 at 4:43 PM
While diversity initiatives are under attack, at the netherlands cancer institute (@nkinl.bsky.social) we firmly believe in creating an inclusive & diverse environment! Together with Humanity in Action we hosted a workshop about recognizing and prevent discrimination in healthcare & academia
Reposted by Allard van Renterghem
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology
Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.
go.nature.com
February 4, 2025 at 3:48 PM
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Reposted by Allard van Renterghem
The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
December 5, 2024 at 7:22 PM
The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...