Alf Soler-Bistué 🦠🔬🧫
@alfmicrobe.bsky.social
You may know @AlfMicrobioTweets from Twitter. PI at UNSAM 🇦🇷. Microbiology & genomics.
Microbial, growth, chromosome structure & evolution.
Vibrio, Bradyrhizobium (and Brucella) .
❤️🧪🦠Microbiology 🔬🧫❤️
Editor @ Curr. microbiology.
Microbial, growth, chromosome structure & evolution.
Vibrio, Bradyrhizobium (and Brucella) .
❤️🧪🦠Microbiology 🔬🧫❤️
Editor @ Curr. microbiology.
Old tools for new problems: how to get glyphosate resistant/degrading bacteria using Winogradsky columns...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Materials-Based spatiotemporal analysis of microbial responses to glyphosate in Winogradsky columns
Glyphosate, the active ingredient in many broad-spectrum herbicides, is extensively used in agriculture but has come under increasing scrutiny due to …
www.sciencedirect.com
November 1, 2025 at 4:50 PM
Old tools for new problems: how to get glyphosate resistant/degrading bacteria using Winogradsky columns...
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Alf Soler-Bistué 🦠🔬🧫
Thanks to the authors of this piece. I love reading about the work of inspiring pioneers in bacterial genetics. Crazy amount of discoveries!
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
academic.oup.com/genetics/adv...
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
academic.oup.com/genetics/adv...
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
Abstract. Esther Miriam Lederberg's brilliant scientific lifework, from the discovery of phage lambda, bacterial conjugation, and replica plating, provided
academic.oup.com
September 4, 2025 at 9:25 AM
Thanks to the authors of this piece. I love reading about the work of inspiring pioneers in bacterial genetics. Crazy amount of discoveries!
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
academic.oup.com/genetics/adv...
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
academic.oup.com/genetics/adv...
Super honored to have contributed to this excellent Reviews article by @val-meve.bsky.social and @amazeld.bsky.social on how extrachromosomal replicons (secondary chromosomes, chromids, megaplasmids) emerge in bacteria! 🦠 🧫
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Taming wild replicons: evolution and domestication of large extrachromosomal replicons
Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as meg…
www.sciencedirect.com
August 21, 2025 at 2:55 PM
Super honored to have contributed to this excellent Reviews article by @val-meve.bsky.social and @amazeld.bsky.social on how extrachromosomal replicons (secondary chromosomes, chromids, megaplasmids) emerge in bacteria! 🦠 🧫
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Alf Soler-Bistué 🦠🔬🧫
Nuestros encuentros tempranos con bacterias son cruciales para el desarrollo de nuestro sistema inmunológico, muestra un estudio británico 👇
www.bbc.com/news/article...
www.bbc.com/news/article...
Microbiome: First bacteria we meet can keep us out of hospital
For the first time, scientists show how our microbiome forms affects the risk of infection.
www.bbc.com
June 5, 2025 at 6:21 PM
Nuestros encuentros tempranos con bacterias son cruciales para el desarrollo de nuestro sistema inmunológico, muestra un estudio británico 👇
www.bbc.com/news/article...
www.bbc.com/news/article...
Great paper on replication dynamics in E. coli with more than one oriC. What would happen if we further add more oriCs??
frontiersin.org/journals/mic...
Congrats Ole Skovgaad for this sound paper!!
frontiersin.org/journals/mic...
Congrats Ole Skovgaad for this sound paper!!
Frontiers | An additional replication origin causes cell cycle specific DNA replication fork speed
frontiersin.org
June 6, 2025 at 4:24 PM
Great paper on replication dynamics in E. coli with more than one oriC. What would happen if we further add more oriCs??
frontiersin.org/journals/mic...
Congrats Ole Skovgaad for this sound paper!!
frontiersin.org/journals/mic...
Congrats Ole Skovgaad for this sound paper!!
Reposted by Alf Soler-Bistué 🦠🔬🧫
La intervención de @VLeviLab ayer, en el Senado. También im-per-di-ble 👇
www.youtube.com/watch?v=QgTU...
www.youtube.com/watch?v=QgTU...
VALERIA LEVY - COMISIÓN DE CIENCIA Y TECNOLOGÍA 04-06-25
YouTube video by Senado Argentina
www.youtube.com
June 5, 2025 at 7:47 PM
La intervención de @VLeviLab ayer, en el Senado. También im-per-di-ble 👇
www.youtube.com/watch?v=QgTU...
www.youtube.com/watch?v=QgTU...
Reposted by Alf Soler-Bistué 🦠🔬🧫
Here is our newest paper recently published in Plant Communications on "Root hair growth under the control of auxin under low temperature low nutrient environment". Comments and suggestions are more than welcome! Here the pdf www.cell.com/plant-commun... Leaded by Victoria Berdion Gabarain et al.
June 5, 2025 at 8:15 PM
Here is our newest paper recently published in Plant Communications on "Root hair growth under the control of auxin under low temperature low nutrient environment". Comments and suggestions are more than welcome! Here the pdf www.cell.com/plant-commun... Leaded by Victoria Berdion Gabarain et al.
Reposted by Alf Soler-Bistué 🦠🔬🧫
schaechter.asmblog.org/schaechter/2...
(sorry for being late with today's 𝘕𝘰𝘵𝘦𝘸𝘰𝘳𝘵𝘩𝘺. we are not "up, up and away" because of ascension day, we simply overslept 🤦♂️) #MicroSky
(sorry for being late with today's 𝘕𝘰𝘵𝘦𝘸𝘰𝘳𝘵𝘩𝘺. we are not "up, up and away" because of ascension day, we simply overslept 🤦♂️) #MicroSky
Gene Location Matters
Noteworthy — Bacterial genomes are not a laundry list of genes, but dynamic structures intimately connected with cellular function. As a result, natural selection has a heavy hand in shaping chromosom...
schaechter.asmblog.org
May 29, 2025 at 4:06 PM
schaechter.asmblog.org/schaechter/2...
(sorry for being late with today's 𝘕𝘰𝘵𝘦𝘸𝘰𝘳𝘵𝘩𝘺. we are not "up, up and away" because of ascension day, we simply overslept 🤦♂️) #MicroSky
(sorry for being late with today's 𝘕𝘰𝘵𝘦𝘸𝘰𝘳𝘵𝘩𝘺. we are not "up, up and away" because of ascension day, we simply overslept 🤦♂️) #MicroSky
Reposted by Alf Soler-Bistué 🦠🔬🧫
🌱 New manuscript out, with a strong taste of RESISTANCE.
🦠 We genetically improved a commercial soybean inoculant to degrade glyphosate.
🧬 A single mutation boosts stress tolerance & herbicide breakdown.
🌿 Positive impact on productivity & environmental health.
📄 Read it: doi.org/10.1016/j.rh...
🦠 We genetically improved a commercial soybean inoculant to degrade glyphosate.
🧬 A single mutation boosts stress tolerance & herbicide breakdown.
🌿 Positive impact on productivity & environmental health.
📄 Read it: doi.org/10.1016/j.rh...
May 30, 2025 at 10:11 PM
🌱 New manuscript out, with a strong taste of RESISTANCE.
🦠 We genetically improved a commercial soybean inoculant to degrade glyphosate.
🧬 A single mutation boosts stress tolerance & herbicide breakdown.
🌿 Positive impact on productivity & environmental health.
📄 Read it: doi.org/10.1016/j.rh...
🦠 We genetically improved a commercial soybean inoculant to degrade glyphosate.
🧬 A single mutation boosts stress tolerance & herbicide breakdown.
🌿 Positive impact on productivity & environmental health.
📄 Read it: doi.org/10.1016/j.rh...
Reposted by Alf Soler-Bistué 🦠🔬🧫
😍Un equipo de la UBA se ubicó entre los 5 mejores (de más de 100) en el mundial de “satélites enlatados”👇en la final del proyecto CanSat, organizado por la Universidad Nacional de México, con un satélite del tamaño de una lata que ellos mismos diseñaron y fabricaron 👇
May 28, 2025 at 6:14 PM
😍Un equipo de la UBA se ubicó entre los 5 mejores (de más de 100) en el mundial de “satélites enlatados”👇en la final del proyecto CanSat, organizado por la Universidad Nacional de México, con un satélite del tamaño de una lata que ellos mismos diseñaron y fabricaron 👇
Budget cuts do not curb our enthusiasm! Ian lab meeting today on Bradyrhizobium cell physiology! #LabMeetinDay
May 29, 2025 at 2:20 PM
Budget cuts do not curb our enthusiasm! Ian lab meeting today on Bradyrhizobium cell physiology! #LabMeetinDay
Estas en 3-4° año de biotecnología o carreras afines? Estamos buscando un/a estudiante de @unsamoficial.bsky.social para incorporar al laboratorio y presentar a una beca de entrenamiento de la CIC PBA! Te interesa? Vení a trabajar con nosotros!! #UNSAM #Biotecnologia !!
May 26, 2025 at 8:35 PM
Estas en 3-4° año de biotecnología o carreras afines? Estamos buscando un/a estudiante de @unsamoficial.bsky.social para incorporar al laboratorio y presentar a una beca de entrenamiento de la CIC PBA! Te interesa? Vení a trabajar con nosotros!! #UNSAM #Biotecnologia !!
What a huge story!!! Integrons are page resistance genes carriers!!! Not just silent " long term memory" geneyic structures!! Congrats two all the team!!
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 10, 2025 at 11:55 AM
What a huge story!!! Integrons are page resistance genes carriers!!! Not just silent " long term memory" geneyic structures!! Congrats two all the team!!
Certainly a great place for a posdoctoral experience! Highly recommended!!!
WARNING: We have a postdoc position to work on the follow-up of this work. If you're interested, the deadline is tomorrow !!! (but I'll wait a few more days for interested candidates). research.pasteur.fr/fr/job/postd...
May 10, 2025 at 11:53 AM
Certainly a great place for a posdoctoral experience! Highly recommended!!!
Huge story by @celineloot.bsky.social ! The chromosomal integrons are reservoirs of defense systems against Phages!
At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 10, 2025 at 11:52 AM
Huge story by @celineloot.bsky.social ! The chromosomal integrons are reservoirs of defense systems against Phages!
Reposted by Alf Soler-Bistué 🦠🔬🧫
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 8, 2025 at 8:27 PM
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Submitted! Fingers crossed!!
May 7, 2025 at 1:50 PM
Submitted! Fingers crossed!!
Reposted by Alf Soler-Bistué 🦠🔬🧫
📢 III Curso Avanzado en Biología Molecular y Biotecnología Vegetal. 5 - 14 Mayo. Presencial, Universidad de Chile. Estudiantes de pregrado, doctorado, post-doc y técnicos. Clases con investigadores de primer nivel, últimas innovaciones en biotecnología vegetal. Empresas líderes en la industria.
May 2, 2025 at 8:37 PM
📢 III Curso Avanzado en Biología Molecular y Biotecnología Vegetal. 5 - 14 Mayo. Presencial, Universidad de Chile. Estudiantes de pregrado, doctorado, post-doc y técnicos. Clases con investigadores de primer nivel, últimas innovaciones en biotecnología vegetal. Empresas líderes en la industria.
And its out! Last work of the lab: "Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of
Fast-Growing Bacteria."
We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...
Fast-Growing Bacteria."
We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...
Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria..
The influence of gene order within the chromosome on cellular homeostasis and genome evolution remains unclear. Bacterial chromosomes are structured along the replication origin ( oriC )-terminus ( te...
www.biorxiv.org
April 15, 2025 at 4:50 AM
And its out! Last work of the lab: "Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of
Fast-Growing Bacteria."
We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...
Fast-Growing Bacteria."
We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...
Reposted by Alf Soler-Bistué 🦠🔬🧫
Sin mucho para festejar en el Día Nacional del Investigador Científico. Según la Ley de Financiamiento de la Ciencia, aprobada por unanimidad, este año debía invertirse el 0,45% del PBI. En lugar de eso... 👇
April 10, 2025 at 11:20 PM
Sin mucho para festejar en el Día Nacional del Investigador Científico. Según la Ley de Financiamiento de la Ciencia, aprobada por unanimidad, este año debía invertirse el 0,45% del PBI. En lugar de eso... 👇
Reposted by Alf Soler-Bistué 🦠🔬🧫
Hoy en la Argentina es el Día del/a investigador/a científico/a por el natalicio de Bernardo Houssay. Houssay fue Premio Nobel de Medicina y fundador del Conicet, del que fue su primer presidente. El Conicet hoy está siendo desmantelado por el gobierno
unr.edu.ar/dia-nacional...
unr.edu.ar/dia-nacional...
April 10, 2025 at 4:30 PM
Hoy en la Argentina es el Día del/a investigador/a científico/a por el natalicio de Bernardo Houssay. Houssay fue Premio Nobel de Medicina y fundador del Conicet, del que fue su primer presidente. El Conicet hoy está siendo desmantelado por el gobierno
unr.edu.ar/dia-nacional...
unr.edu.ar/dia-nacional...
I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
Most bacterial gene families are biased toward specific chromosomal positions
The arrangement of genes along bacterial chromosomes influences their expression through growth rate–dependent gene copy number changes during DNA replication. Although translation- and transcription-...
www.science.org
April 10, 2025 at 7:43 PM
I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...
Reposted by Alf Soler-Bistué 🦠🔬🧫
As new Editor in Chief of Evolution, Medicine, and Public Health, an OA society journal of ISEMPH, we welcome papers at the interface of evolution and medicine. I especially encourage studies in infection biology, broadly construed. We're a great and constructive journal! academic.oup.com/emph
April 10, 2025 at 4:50 PM
As new Editor in Chief of Evolution, Medicine, and Public Health, an OA society journal of ISEMPH, we welcome papers at the interface of evolution and medicine. I especially encourage studies in infection biology, broadly construed. We're a great and constructive journal! academic.oup.com/emph
Gran Curso de Biología Vegetal en Chile! Coordina el gran @estevezjosem.bsky.social
March 20, 2025 at 3:53 PM
Gran Curso de Biología Vegetal en Chile! Coordina el gran @estevezjosem.bsky.social