🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇
www.clinicbarcelona.org/uploads/medi...

Un estudi revela com les mutacions pro-tumorals a l'esòfag s'expandeixen durant l'envelliment

https://s.mtrbio.com/gispeedbnb @albertpol.bsky.social @albertherms.bsky.social

We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇
www.clinicbarcelona.org/uploads/medi...

'iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells'
www.nature.com/articles/s41...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

#IDIBAPS IN-HOUSE Seminar

Understanding how mutant cells colonize normal epithelia

📆12/12
🕰️15:00
👨‍🔬Albert Herms
📍 Esteve Auditorium, Centre Esther Koplowitz
💻 Hybrid event: https://bit.ly/3BecnUR

👉 https://bit.ly/3ZEfOgW

🆕A 3D culture system makes it possible to simulate the behavior of epithelial tissue

This technique is an key step forward in understanding how mutations expand in tissues as we age
@albertherms.bsky.social @albertpol.bsky.social @hospitalclinic.bsky.social

www.clinicbarcelona.org/en/news/a-ne...

'High-density sampling reveals volume growth in human tumours'
elifesciences.org/reviewed-pre...

We recently announced a dual new release of intOGen and boostDM

Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations

➡️ Compendium of Cancer Driver Genes - www.intogen.org

➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

Obesity-dependent selection of driver mutations in cancer - Nature Genetics 🧪
www.nature.com/articles/s41...

Congrats to Ed Reznik & colleagues

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

CGI-Clinics project just joined Bluesky.

Follow it to stay tuned on exciting updates coming soon about the project

👉 @cgiclinics.bsky.social

cgiclinics.eu

Our group investigates the role of #lipid droplets (green) in killing intracellular pathogens (blue, E coli in human macrophages) when they are searching for nutrients. In our family we have nicknamed them defensive lipid droplets and FATal attraction. Credit @robparton.bsky.social @UQpress

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy 🧪
www.cell.com/cell/fulltex...