@alansaghatelian.bsky.social
Reposted
This week, scientists in David Liu’s lab at the @broadinstitute.org report on a single gene therapy that they say might someday address many genetic diseases. cen.acs.org/biological-c... #chemsky 🧪
Prime editing suppressor transfer RNAs for gene therapy
Liu lab suggests technique could provide ‘nonstop’ treatment for genetic diseases
cen.acs.org
November 20, 2025 at 8:57 PM
This week, scientists in David Liu’s lab at the @broadinstitute.org report on a single gene therapy that they say might someday address many genetic diseases. cen.acs.org/biological-c... #chemsky 🧪
Reposted
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Reposted
Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 11:58 PM
Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted
Illustrated Periodic Tables Featuring the Superheroes and Villains of Marvel and DC Comics laughingsquid.com/marvel-dc-co...
Illustrated Periodic Tables Featuring the Superheroes and Villains of Marvel and DC Comics
Melanie Scott wrote two wonderful books, each featuring the superheroes and villains of Marvel and DC Comics as elements in periodic tables.
laughingsquid.com
February 24, 2025 at 3:41 PM
Reposted
Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers.
www.nopatientleftbehind.org/defending-th...
www.nopatientleftbehind.org/defending-th...
Defending the NIH, the NSF and the foundation of American science — No Patient Left Behind
www.nopatientleftbehind.org
February 23, 2025 at 2:39 AM
Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers.
www.nopatientleftbehind.org/defending-th...
www.nopatientleftbehind.org/defending-th...
Reposted
Better not call it a “vaccine” or it might not get approved. Maybe market it as a recreational drug.
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
buff.ly
February 22, 2025 at 12:44 AM
Better not call it a “vaccine” or it might not get approved. Maybe market it as a recreational drug.
Reposted
When Rupert Murdoch’s rags turn on you …
February 21, 2025 at 9:09 PM
When Rupert Murdoch’s rags turn on you …
Reposted
New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
www.biorxiv.org
February 18, 2025 at 7:18 PM
New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...
Reposted
Got word that several NIH employees in a group working on cancer clinical trials got terminated via email this evening.
“The [cancer research] trials will literally not be able to function without us.”
Trump and Musk are killing cancer research. 🧪
“The [cancer research] trials will literally not be able to function without us.”
Trump and Musk are killing cancer research. 🧪
February 16, 2025 at 2:43 AM
Got word that several NIH employees in a group working on cancer clinical trials got terminated via email this evening.
“The [cancer research] trials will literally not be able to function without us.”
Trump and Musk are killing cancer research. 🧪
“The [cancer research] trials will literally not be able to function without us.”
Trump and Musk are killing cancer research. 🧪
Reposted
You can sell with the truth. It’s still about presentation.
“Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.
“Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.
Point taken. But isn't that bc Trump's a scammer? It's a lot easier to sell a fantasy, especially if you wrap it in promises of riches and self-righteous vengeance. As well as promise fake solutions to problems that don't exist or that he created. Not sure if being more like Trump is the answer?!
February 14, 2025 at 6:36 PM
You can sell with the truth. It’s still about presentation.
“Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.
“Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.
Reposted
(Sorry I took a brief timeout for uncontrollable weeping)
In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000.
Lots of folks extramural staff, intramural scientists, etc.
In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000.
Lots of folks extramural staff, intramural scientists, etc.
a man with glasses and a mustache is making a sad face
ALT: a man with glasses and a mustache is making a sad face
media.tenor.com
February 14, 2025 at 5:10 PM
(Sorry I took a brief timeout for uncontrollable weeping)
In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000.
Lots of folks extramural staff, intramural scientists, etc.
In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000.
Lots of folks extramural staff, intramural scientists, etc.
Reposted
Folks: I am NOT affiliated with the group that is using my name to support an economic boycott. Please spread this post, if you would.
February 13, 2025 at 4:05 PM
Folks: I am NOT affiliated with the group that is using my name to support an economic boycott. Please spread this post, if you would.
Reposted
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature
A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.
www.nature.com
February 13, 2025 at 2:42 PM
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs…
“I think they're being short-sighted, because fear does that to you.”
“I think they're being short-sighted, because fear does that to you.”
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 7:41 PM
Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs…
“I think they're being short-sighted, because fear does that to you.”
“I think they're being short-sighted, because fear does that to you.”
Reposted
This youtube video, also from AAU, is great for friends and families that might not understand. www.youtube.com/watch?v=yxTD...
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
www.youtube.com
February 12, 2025 at 4:03 PM
This youtube video, also from AAU, is great for friends and families that might not understand. www.youtube.com/watch?v=yxTD...
Reposted
This is outstanding! Watch it and share...
This youtube video, also from AAU, is great for friends and families that might not understand. www.youtube.com/watch?v=yxTD...
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
www.youtube.com
February 12, 2025 at 4:41 PM
This is outstanding! Watch it and share...
Reposted
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Reposted
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 4:45 PM
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Reposted
Mark Cuban on NIH.
Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2
Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 11:24 PM
Mark Cuban on NIH.
Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2
Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2
Reposted
NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
February 8, 2025 at 3:07 PM
NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes
Investing in NIH = investing in life-saving discoveries.
Reposted
F99/R00 AND K99/R00 DIVERSITY AWARD APPLICANTS
If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me.
DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78
THANK YOU
If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me.
DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78
THANK YOU
a picture of a cartoon character with the words call me on it
ALT: a picture of a cartoon character with the words call me on it
media.tenor.com
February 9, 2025 at 5:25 PM
F99/R00 AND K99/R00 DIVERSITY AWARD APPLICANTS
If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me.
DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78
THANK YOU
If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me.
DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78
THANK YOU
Reposted
Contacting your congressperson is fine.
But contacting your local TV station is better.
One interview on local TV saying your congressperson should act is worth 1,000 office calls.
But contacting your local TV station is better.
One interview on local TV saying your congressperson should act is worth 1,000 office calls.
In case folks are interested in contacting their congresspeople about the NIH indirect cuts with some estimates of what they would mean for institutions in their state, here are some estimates based on published F&A rates and funding ... let me know if you want a particular state
February 8, 2025 at 6:58 PM
Contacting your congressperson is fine.
But contacting your local TV station is better.
One interview on local TV saying your congressperson should act is worth 1,000 office calls.
But contacting your local TV station is better.
One interview on local TV saying your congressperson should act is worth 1,000 office calls.
Reposted
The NIH cuts are being spun as a way to eliminate bloated university bureaucracy. And looking at the sheer numbers, I get it.
But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵
1/
But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵
1/
February 8, 2025 at 7:25 PM
The NIH cuts are being spun as a way to eliminate bloated university bureaucracy. And looking at the sheer numbers, I get it.
But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵
1/
But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵
1/
Reposted
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com
February 8, 2025 at 5:12 PM
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
Reposted
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 3:08 AM
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.