Adam Marblestone
@adammarblestone.bsky.social
Technologist, scientist. Co-founder of Convergent Research.
Reposted by Adam Marblestone
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1
November 26, 2025 at 8:16 AM
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1
Reposted by Adam Marblestone
It's been an incredibly exciting year in metascience at large, and for us at Convergent.
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
The Future of Focused Research Organizations:
Working with Convergent on the NSF Tech Labs Initiative
www.essentialtechnology.blog
December 23, 2025 at 9:12 PM
It's been an incredibly exciting year in metascience at large, and for us at Convergent.
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Reposted by Adam Marblestone
Dim Red Dot
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
December 18, 2025 at 11:17 AM
Dim Red Dot
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Reposted by Adam Marblestone
Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
December 16, 2025 at 4:06 PM
Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
Reposted by Adam Marblestone
A Vision of Metascience; How does the culture of science change and improve?
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
December 1, 2024 at 12:27 PM
A Vision of Metascience; How does the culture of science change and improve?
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
Reposted by Adam Marblestone
To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play:
fas.org/publication/...
fas.org/publication/...
NSF Wants To Supercharge FROs. We Spoke With the Scientists Who Proposed Them.
We recently spoke with Adam Marblestone and Sam Rodriques, former FAS fellows who developed the idea for FROs and advocated for their use in a 2020 policy memo.
fas.org
December 12, 2025 at 4:49 PM
To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play:
fas.org/publication/...
fas.org/publication/...
If you've been interested in FROs, you'll want to see this from NSF:
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
December 12, 2025 at 4:19 PM
If you've been interested in FROs, you'll want to see this from NSF:
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
Reposted by Adam Marblestone
A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1
December 7, 2025 at 2:02 AM
A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1
Reposted by Adam Marblestone
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
[C]Worthy Secures Multi-Year Support From ORCA and the Patrick J. McGovern Foundation to Scale Open-Source Marine Carbon-Removal Tools — [C]Worthy
New multi‑year awards affirm the need for infrastructure built through [C]Worthy’s approach of marrying open-source science and practical tools for industry use.
www.cworthy.org
November 24, 2025 at 4:26 PM
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
Reposted by Adam Marblestone
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 21, 2025 at 3:07 PM
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
Reposted by Adam Marblestone
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Active learning guides automated discovery of DNA delivery via electroporation for non-model microbes
Delivery of recombinant DNA is foundational for understanding and engineering a target organism. Electroporation can be applied to any cell type, yet identification of a working protocol for new organ...
www.biorxiv.org
November 22, 2025 at 12:23 AM
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Marblestone
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 3:44 PM
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Reposted by Adam Marblestone
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.
November 17, 2025 at 2:32 PM
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Reposted by Adam Marblestone
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Programme development | Trust Everything, Everywhere
We are in the process of building a multi-year R&D programme within this space. Our programmes are designed to advance complex, large-scale ideas that require coordinated investment and management acr...
link.aria.org.uk
November 17, 2025 at 2:50 PM
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Reposted by Adam Marblestone
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Same for neuroscience. The lack of ability to measure many neurons’ activity, perturb them, and measure intracellular processes and connections is what limits understanding the brain.
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
November 17, 2025 at 1:23 AM
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Reposted by Adam Marblestone
Reposted by Adam Marblestone
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
November 12, 2025 at 8:03 PM
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
Reposted by Adam Marblestone
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
November 12, 2025 at 7:05 PM
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
Reposted by Adam Marblestone
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
The songbird basal ganglia connectome
The basal ganglia (BG) play an essential role in shaping vertebrate behavior, ranging from motor learning to emotions, but comprehensive maps of their canonical synaptic architecture are missing. In m...
www.biorxiv.org
October 30, 2025 at 6:07 PM
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
Reposted by Adam Marblestone
Our new preprint outlining how to make 1000-plex mass tags!
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:41 PM
Our new preprint outlining how to make 1000-plex mass tags!
Reposted by Adam Marblestone
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:08 PM
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪