@kmcdonnell.bsky.social
Our new preprint outlining how to make 1000-plex mass tags!
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:41 PM
Our new preprint outlining how to make 1000-plex mass tags!
Reposted
We are excited to introduce ‘time’ as a new domain for proteomics multiplexing!
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
May 28, 2025 at 10:05 AM
We are excited to introduce ‘time’ as a new domain for proteomics multiplexing!
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
Reposted
🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 28, 2025 at 12:21 PM
🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
Increasing throughput in mass spec proteomics requires new ways to model the increased complexity of the spectra.
We are delighted to share JMod, our new open source software developed at @parallelsq.bsky.social , which enables new multiplexing approaches.
1/7
www.biorxiv.org/content/10.1...
We are delighted to share JMod, our new open source software developed at @parallelsq.bsky.social , which enables new multiplexing approaches.
1/7
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 28, 2025 at 11:40 AM
Increasing throughput in mass spec proteomics requires new ways to model the increased complexity of the spectra.
We are delighted to share JMod, our new open source software developed at @parallelsq.bsky.social , which enables new multiplexing approaches.
1/7
www.biorxiv.org/content/10.1...
We are delighted to share JMod, our new open source software developed at @parallelsq.bsky.social , which enables new multiplexing approaches.
1/7
www.biorxiv.org/content/10.1...